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Optical deformation of red blood cells trapped on a narrow waveguide

Optical deformation of red blood cells trapped on a narrow waveguide
Optical deformation of red blood cells trapped on a narrow waveguide
Reduced blood deformability is clinically linked to several diseases. It is important to develop sensitive tools to measure the loss of blood deformability. The evanescent field of an optical waveguide can trap and propel red blood cells along the waveguide. Here we propose to use the evanescent field from a narrow optical waveguide to trap and deform red blood cells. We demonstrate that the intensity gradient of the evanescent field at the edge of narrow waveguides (1-3 ?m) can be used to squeeze a blood cell. The RBCs are squeezed to a size comparable to the waveguide width. When the laser is switched on the cell is attracted towards the waveguide and is held in place. Subsequently, the part of the cell not on the waveguide is pulled in across the waveguide. The result is a cell (7-8 ?m in diameter) squeezed down to a significantly smaller width (typically 3 ?m). The cell regains its original shape when laser is switched-off.
Ahluwalia, Balpreet Singh
f6dfb1bb-760f-4a7e-9050-d66de72348e0
McCourt, Peter
5786a794-fbdb-4215-afae-d558d98bf60c
Wilkinson, James S.
73483cf3-d9f2-4688-9b09-1c84257884ca
Huser, Thomas R.
f1aa9651-07f8-423b-8e96-05b45bbdee83
Hellesø, Olav Gaute
a686e598-f575-4a27-94c6-fa6a088cdf61
Ahluwalia, Balpreet Singh
f6dfb1bb-760f-4a7e-9050-d66de72348e0
McCourt, Peter
5786a794-fbdb-4215-afae-d558d98bf60c
Wilkinson, James S.
73483cf3-d9f2-4688-9b09-1c84257884ca
Huser, Thomas R.
f1aa9651-07f8-423b-8e96-05b45bbdee83
Hellesø, Olav Gaute
a686e598-f575-4a27-94c6-fa6a088cdf61

Ahluwalia, Balpreet Singh, McCourt, Peter, Wilkinson, James S., Huser, Thomas R. and Hellesø, Olav Gaute (2014) Optical deformation of red blood cells trapped on a narrow waveguide. Conference on Optical Trapping and Optical Micromanipulation XI: SPIE 9164, United States. 17 - 21 Aug 2014. (doi:10.1117/12.2062590).

Record type: Conference or Workshop Item (Paper)

Abstract

Reduced blood deformability is clinically linked to several diseases. It is important to develop sensitive tools to measure the loss of blood deformability. The evanescent field of an optical waveguide can trap and propel red blood cells along the waveguide. Here we propose to use the evanescent field from a narrow optical waveguide to trap and deform red blood cells. We demonstrate that the intensity gradient of the evanescent field at the edge of narrow waveguides (1-3 ?m) can be used to squeeze a blood cell. The RBCs are squeezed to a size comparable to the waveguide width. When the laser is switched on the cell is attracted towards the waveguide and is held in place. Subsequently, the part of the cell not on the waveguide is pulled in across the waveguide. The result is a cell (7-8 ?m in diameter) squeezed down to a significantly smaller width (typically 3 ?m). The cell regains its original shape when laser is switched-off.

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More information

Published date: 17 August 2014
Venue - Dates: Conference on Optical Trapping and Optical Micromanipulation XI: SPIE 9164, United States, 2014-08-17 - 2014-08-21

Identifiers

Local EPrints ID: 442585
URI: http://eprints.soton.ac.uk/id/eprint/442585
PURE UUID: 1000f741-b1f4-4c74-b60f-007e07ae63f8
ORCID for James S. Wilkinson: ORCID iD orcid.org/0000-0003-4712-1697

Catalogue record

Date deposited: 20 Jul 2020 16:31
Last modified: 18 Feb 2021 16:32

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