Webb, Jeremy, Frapwell, Connor, Duignan, Caroline, Aiken, S., Cooper, J, Stoodley, Paul and Howlin, Robert (2018) Antibiofilm efficacy of antibiotic-loaded synthetic calcium sulphate beads in a P. aeruginosa/S. aureus co-culture model for prosthetic infections. Orthopaedic Proceedings, 99 (SUPP_22), 59. (doi:10.1302/1358-992X.2017.22.059).
Abstract
Bacterial biofilms play a key role in prosthetic infection (PI) pathogenesis. Establishment of the biofilm phenotype confers the bacteria with significant tolerance to systemic antibiotics and the host immune system meaning thorough debridement and prosthesis removal often remain the only possible course of treatment. Protection of the prosthesis and dead-space management may be achieved through the use of antibiotic loaded cements and beads to release high concentrations of antibiotics at the surgical site. The antibacterial and antibiofilm efficacy of these materials is poorly understood in the context of mixed species models, such as are often encountered clinically.
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- Current Faculties > Faculty of Engineering and Physical Sciences > School of Engineering > Mechanical Engineering > nCATS Group
Mechanical Engineering > nCATS Group - Faculties (pre 2018 reorg) > Faculty of Engineering and the Environment (pre 2018 reorg) > Southampton Marine & Maritime Institute (pre 2018 reorg)
- Current Faculties > Faculty of Environmental and Life Sciences > School of Biological Sciences > Microbiology
School of Biological Sciences > Microbiology - Current Faculties > Faculty of Environmental and Life Sciences > Institute for Life Sciences > Biofilms
Institute for Life Sciences > Biofilms - Faculties (pre 2018 reorg) > Faculty of Natural and Environmental Sciences (pre 2018 reorg) > Institute for Life Sciences (pre 2018 reorg)
Current Faculties > Faculty of Environmental and Life Sciences > Institute for Life Sciences > Institute for Life Sciences (pre 2018 reorg)
Institute for Life Sciences > Institute for Life Sciences (pre 2018 reorg)
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