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Antibiofilm efficacy of antibiotic-loaded synthetic calcium sulphate beads in a P. aeruginosa/S. aureus co-culture model for prosthetic infections

Antibiofilm efficacy of antibiotic-loaded synthetic calcium sulphate beads in a P. aeruginosa/S. aureus co-culture model for prosthetic infections
Antibiofilm efficacy of antibiotic-loaded synthetic calcium sulphate beads in a P. aeruginosa/S. aureus co-culture model for prosthetic infections
Bacterial biofilms play a key role in prosthetic infection (PI) pathogenesis. Establishment of the biofilm phenotype confers the bacteria with significant tolerance to systemic antibiotics and the host immune system meaning thorough debridement and prosthesis removal often remain the only possible course of treatment. Protection of the prosthesis and dead-space management may be achieved through the use of antibiotic loaded cements and beads to release high concentrations of antibiotics at the surgical site. The antibacterial and antibiofilm efficacy of these materials is poorly understood in the context of mixed species models, such as are often encountered clinically.
1358-992X
59
Webb, Jeremy
ec0a5c4e-86cc-4ae9-b390-7298f5d65f8d
Frapwell, Connor
687070ab-1e5c-46ef-8450-9f3f5a566e7f
Duignan, Caroline
48bd5ba4-ef7a-4ac0-8c46-faeaa47f2792
Aiken, S.
4d136549-2d04-4abc-a9a5-4e81d42e99b8
Cooper, J
e755699a-8bfb-40a1-98f1-b5d3d0ae82e5
Stoodley, Paul
08614665-92a9-4466-806e-20c6daeb483f
Howlin, Robert
f3c84990-6196-47d4-ad8a-80954ea46c7f
Webb, Jeremy
ec0a5c4e-86cc-4ae9-b390-7298f5d65f8d
Frapwell, Connor
687070ab-1e5c-46ef-8450-9f3f5a566e7f
Duignan, Caroline
48bd5ba4-ef7a-4ac0-8c46-faeaa47f2792
Aiken, S.
4d136549-2d04-4abc-a9a5-4e81d42e99b8
Cooper, J
e755699a-8bfb-40a1-98f1-b5d3d0ae82e5
Stoodley, Paul
08614665-92a9-4466-806e-20c6daeb483f
Howlin, Robert
f3c84990-6196-47d4-ad8a-80954ea46c7f

Webb, Jeremy, Frapwell, Connor, Duignan, Caroline, Aiken, S., Cooper, J, Stoodley, Paul and Howlin, Robert (2018) Antibiofilm efficacy of antibiotic-loaded synthetic calcium sulphate beads in a P. aeruginosa/S. aureus co-culture model for prosthetic infections. Orthopaedic Proceedings, 99 (SUPP_22), 59. (doi:10.1302/1358-992X.2017.22.059).

Record type: Article

Abstract

Bacterial biofilms play a key role in prosthetic infection (PI) pathogenesis. Establishment of the biofilm phenotype confers the bacteria with significant tolerance to systemic antibiotics and the host immune system meaning thorough debridement and prosthesis removal often remain the only possible course of treatment. Protection of the prosthesis and dead-space management may be achieved through the use of antibiotic loaded cements and beads to release high concentrations of antibiotics at the surgical site. The antibacterial and antibiofilm efficacy of these materials is poorly understood in the context of mixed species models, such as are often encountered clinically.

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More information

e-pub ahead of print date: 21 February 2018

Identifiers

Local EPrints ID: 442614
URI: http://eprints.soton.ac.uk/id/eprint/442614
ISSN: 1358-992X
PURE UUID: fb117452-4425-40af-aebc-fea715eb2f2f
ORCID for Jeremy Webb: ORCID iD orcid.org/0000-0003-2068-8589
ORCID for Paul Stoodley: ORCID iD orcid.org/0000-0001-6069-273X

Catalogue record

Date deposited: 21 Jul 2020 16:32
Last modified: 18 Feb 2021 17:13

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