Antibiofilm efficacy of antibiotic-loaded synthetic calcium sulphate beads in a P. aeruginosa/S. aureus co-culture model for prosthetic infections

Webb, Jeremy, Frapwell, Connor, Duignan, Caroline, Aiken, S., Cooper, J, Stoodley, Paul and Howlin, Robert (2018) Antibiofilm efficacy of antibiotic-loaded synthetic calcium sulphate beads in a P. aeruginosa/S. aureus co-culture model for prosthetic infections. Orthopaedic Proceedings, 99 (SUPP_22), 59. (doi:10.1302/1358-992X.2017.22.059).

Abstract

Bacterial biofilms play a key role in prosthetic infection (PI) pathogenesis. Establishment of the biofilm phenotype confers the bacteria with significant tolerance to systemic antibiotics and the host immune system meaning thorough debridement and prosthesis removal often remain the only possible course of treatment. Protection of the prosthesis and dead-space management may be achieved through the use of antibiotic loaded cements and beads to release high concentrations of antibiotics at the surgical site. The antibacterial and antibiofilm efficacy of these materials is poorly understood in the context of mixed species models, such as are often encountered clinically.

Full text not available from this repository.

Contributors

Author: Jeremy Webb

Author: Paul Stoodley

University divisions

• nCATS Group
• Southampton Marine & Maritime Institute (pre 2018 reorg)
• Microbiology
• Biofilms
• Institute for Life Sciences (pre 2018 reorg)

Download statistics