Changes in metal coordination are required to regulate activity of bacterial phosphodiesterases, implicated in c-di-GMP regulated biofilm dispersal

Webb, Jeremy, Hutchin, Andrew James, Bellini, Dom, Horrell, Sam, Phippen, Curtis, Cai, Yuming, Strange, Richard W., Wagner, Armin, Walsh, Martin A. and Tews, Ivo (2016) Changes in metal coordination are required to regulate activity of bacterial phosphodiesterases, implicated in c-di-GMP regulated biofilm dispersal. Acta Crystallographica Section A: Foundations and Advances, 72 (Supplement 1), S39-S40. (doi:10.1107/S2053273316099381).

Abstract

Bacterial biofilms play a key role in prosthetic infection (PI) pathogenesis. Establishment of the biofilm phenotype confers the bacteria with significant tolerance to systemic antibiotics and the host immune system meaning thorough debridement and prosthesis removal often remain the only possible course of treatment. Protection of the prosthesis and dead-space management may be achieved through the use of antibiotic loaded cements and beads to release high concentrations of antibiotics at the surgical site. The antibacterial and antibiofilm efficacy of these materials is poorly understood in the context of mixed species models, such as are often encountered clinically.

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Contributors

Author: Jeremy Webb

Author: Ivo Tews

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