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Changes in metal coordination are required to regulate activity of bacterial phosphodiesterases, implicated in c-di-GMP regulated biofilm dispersal

Changes in metal coordination are required to regulate activity of bacterial phosphodiesterases, implicated in c-di-GMP regulated biofilm dispersal
Changes in metal coordination are required to regulate activity of bacterial phosphodiesterases, implicated in c-di-GMP regulated biofilm dispersal
Bacterial biofilms play a key role in prosthetic infection (PI) pathogenesis. Establishment of the biofilm phenotype confers the bacteria with significant tolerance to systemic antibiotics and the host immune system meaning thorough debridement and prosthesis removal often remain the only possible course of treatment. Protection of the prosthesis and dead-space management may be achieved through the use of antibiotic loaded cements and beads to release high concentrations of antibiotics at the surgical site. The antibacterial and antibiofilm efficacy of these materials is poorly understood in the context of mixed species models, such as are often encountered clinically.
2053-2733
S39-S40
Webb, Jeremy
ec0a5c4e-86cc-4ae9-b390-7298f5d65f8d
Hutchin, Andrew James
5659cf31-f52e-451e-9cf0-4e786924d1ae
Bellini, Dom
39c25764-e748-4639-9df2-197e74083002
Horrell, Sam
a9a13833-811f-4932-971c-1bd2e36c3ad2
Phippen, Curtis
82362439-962f-43e1-89a9-20b2b6bb4b88
Cai, Yuming
ec0ec21f-cb8d-4407-aed8-01da53182083
Strange, Richard W.
120909e0-1357-4fdb-9f1d-a0daadf9e414
Wagner, Armin
4ffa8ad8-0190-47bf-b5da-8da47c8dada6
Walsh, Martin A.
c51d771b-68b4-4c84-8906-650fc25bdad3
Tews, Ivo
9117fc5e-d01c-4f8d-a734-5b14d3eee8dd
Webb, Jeremy
ec0a5c4e-86cc-4ae9-b390-7298f5d65f8d
Hutchin, Andrew James
5659cf31-f52e-451e-9cf0-4e786924d1ae
Bellini, Dom
39c25764-e748-4639-9df2-197e74083002
Horrell, Sam
a9a13833-811f-4932-971c-1bd2e36c3ad2
Phippen, Curtis
82362439-962f-43e1-89a9-20b2b6bb4b88
Cai, Yuming
ec0ec21f-cb8d-4407-aed8-01da53182083
Strange, Richard W.
120909e0-1357-4fdb-9f1d-a0daadf9e414
Wagner, Armin
4ffa8ad8-0190-47bf-b5da-8da47c8dada6
Walsh, Martin A.
c51d771b-68b4-4c84-8906-650fc25bdad3
Tews, Ivo
9117fc5e-d01c-4f8d-a734-5b14d3eee8dd

Webb, Jeremy, Hutchin, Andrew James, Bellini, Dom, Horrell, Sam, Phippen, Curtis, Cai, Yuming, Strange, Richard W., Wagner, Armin, Walsh, Martin A. and Tews, Ivo (2016) Changes in metal coordination are required to regulate activity of bacterial phosphodiesterases, implicated in c-di-GMP regulated biofilm dispersal. Acta Crystallographica Section A: Foundations and Advances, 72 (Supplement 1), S39-S40. (doi:10.1107/S2053273316099381).

Record type: Meeting abstract

Abstract

Bacterial biofilms play a key role in prosthetic infection (PI) pathogenesis. Establishment of the biofilm phenotype confers the bacteria with significant tolerance to systemic antibiotics and the host immune system meaning thorough debridement and prosthesis removal often remain the only possible course of treatment. Protection of the prosthesis and dead-space management may be achieved through the use of antibiotic loaded cements and beads to release high concentrations of antibiotics at the surgical site. The antibacterial and antibiofilm efficacy of these materials is poorly understood in the context of mixed species models, such as are often encountered clinically.

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Published date: August 2016

Identifiers

Local EPrints ID: 442617
URI: http://eprints.soton.ac.uk/id/eprint/442617
ISSN: 2053-2733
PURE UUID: 3df6d9a0-a8ee-4b86-a9c6-06c7a46c7c7d
ORCID for Jeremy Webb: ORCID iD orcid.org/0000-0003-2068-8589
ORCID for Ivo Tews: ORCID iD orcid.org/0000-0002-4704-1139

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Date deposited: 21 Jul 2020 16:34
Last modified: 18 Feb 2021 17:15

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Contributors

Author: Jeremy Webb ORCID iD
Author: Andrew James Hutchin
Author: Dom Bellini
Author: Sam Horrell
Author: Curtis Phippen
Author: Yuming Cai
Author: Richard W. Strange
Author: Armin Wagner
Author: Martin A. Walsh
Author: Ivo Tews ORCID iD

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