A comparative study on the physicochemical characteristics of nanoparticles released in vivo from CoCrMo tapers and cement-stem interfaces of total hip replacements
A comparative study on the physicochemical characteristics of nanoparticles released in vivo from CoCrMo tapers and cement-stem interfaces of total hip replacements
The good biocompatibility and corrosion resistance of the bulk CoCrMo alloy has resulted in it being used in the manufacture of implants and load bearing medical devices. These devices, however, can release wear and corrosion products which differ from the composition of the bulk CoCrMo alloy. The physicochemical characteristics of the particles and the associated in vivo reactivity are dictated by the wear mechanisms and electrochemical conditions at the sites of material loss. Debris released from CoCrMo hip bearings, taper junctions, or cement–stem interfaces can, therefore, have different chemical and morphological characteristics, which provide them with different in vivo toxicities. Here, we propose to assess and compare the characteristics of the particles released in vivo from CoCrMo tapers and cement–stem interfaces which have received less attention compared to debris originating from the hip bearings. The study uses state-of-art characterization techniques to provide a detailed understanding of the size, morphology, composition, and chemistry of the particles liberated from the wear and corrosion flakes from revised hip replacements, with an enzymatic treatment. The phase analyses identified Cr
2O
3 nanoparticles released from tapers and cement–stem interfaces, whose composition did not vary with origin or particle morphology. The size distributions showed significantly smaller particles were released from the stems, compared to the particles originating from the corresponding tapers. The investigation demonstrates that the tribocorrosive processes occurring at the taper and stem interfaces both result in Cr
2O
3 nanoparticle formation.
Cobalt Chromium,, Hip replacements, Orthopaedics,, TEM,, nanoparticles,
3311-3322
Crainic, Alina-Mariana
a8df3e5f-a738-4683-acc8-c75433c88cd0
Callisti, Mauro
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Van Veelen, Arjen
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Michalik, Agnieszka
f117a40f-0df7-4130-8a18-2b37cad5bbef
Milton, James A.
9e183221-d0d4-4ddb-aeba-0fdde9d31230
Palmer, Martin
d2e60e81-5d6e-4ddb-a243-602537286080
Cook, Richard
06f8322d-81be-4f82-9326-19e55541c78f
1 November 2020
Crainic, Alina-Mariana
a8df3e5f-a738-4683-acc8-c75433c88cd0
Callisti, Mauro
b925d711-b012-4c01-8a70-fe7bd59d30c9
Van Veelen, Arjen
cb6f2c8b-4671-4836-88a0-3987fd2f2d67
Michalik, Agnieszka
f117a40f-0df7-4130-8a18-2b37cad5bbef
Milton, James A.
9e183221-d0d4-4ddb-aeba-0fdde9d31230
Palmer, Martin
d2e60e81-5d6e-4ddb-a243-602537286080
Cook, Richard
06f8322d-81be-4f82-9326-19e55541c78f
Crainic, Alina-Mariana, Callisti, Mauro, Van Veelen, Arjen, Michalik, Agnieszka, Milton, James A., Palmer, Martin and Cook, Richard
(2020)
A comparative study on the physicochemical characteristics of nanoparticles released in vivo from CoCrMo tapers and cement-stem interfaces of total hip replacements.
Journal of Biomedical Materials Research Part B: Applied Biomaterials, 108 (8), .
(doi:10.1002/jbm.b.34667).
Abstract
The good biocompatibility and corrosion resistance of the bulk CoCrMo alloy has resulted in it being used in the manufacture of implants and load bearing medical devices. These devices, however, can release wear and corrosion products which differ from the composition of the bulk CoCrMo alloy. The physicochemical characteristics of the particles and the associated in vivo reactivity are dictated by the wear mechanisms and electrochemical conditions at the sites of material loss. Debris released from CoCrMo hip bearings, taper junctions, or cement–stem interfaces can, therefore, have different chemical and morphological characteristics, which provide them with different in vivo toxicities. Here, we propose to assess and compare the characteristics of the particles released in vivo from CoCrMo tapers and cement–stem interfaces which have received less attention compared to debris originating from the hip bearings. The study uses state-of-art characterization techniques to provide a detailed understanding of the size, morphology, composition, and chemistry of the particles liberated from the wear and corrosion flakes from revised hip replacements, with an enzymatic treatment. The phase analyses identified Cr
2O
3 nanoparticles released from tapers and cement–stem interfaces, whose composition did not vary with origin or particle morphology. The size distributions showed significantly smaller particles were released from the stems, compared to the particles originating from the corresponding tapers. The investigation demonstrates that the tribocorrosive processes occurring at the taper and stem interfaces both result in Cr
2O
3 nanoparticle formation.
Text
J Biomed Mater Res final full
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More information
Accepted/In Press date: 25 May 2020
e-pub ahead of print date: 28 June 2020
Published date: 1 November 2020
Additional Information:
Funding Information:
The authors would like to acknowledge the ?South of England Analytical Electron Microscope? supported by EPSRC (EP/K040375/1), and Arthroplasty for Arthritis Charity UK for research support. We also gratefully acknowledge the support of the U.S. Department of Energy through the LANL/LDRD Program and the G.T. Seaborg Institute for this work. Los Alamos National Laboratory is operated by Triad National Security, LLC, for the National Nuclear Security Administration of the U.S. Department of Energy (Contract No. 89233218CNA000001). The data used in this study is available at: DOI: https://doi.org/10.5258/SOTON/D1410.
Publisher Copyright:
© 2020 Wiley Periodicals LLC
Keywords:
Cobalt Chromium,, Hip replacements, Orthopaedics,, TEM,, nanoparticles,
Identifiers
Local EPrints ID: 442632
URI: http://eprints.soton.ac.uk/id/eprint/442632
ISSN: 1552-4981
PURE UUID: eb203a6d-6d0b-4e7c-8d16-232eaefe1638
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Date deposited: 21 Jul 2020 16:34
Last modified: 17 Mar 2024 05:45
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Author:
Alina-Mariana Crainic
Author:
Mauro Callisti
Author:
Arjen Van Veelen
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