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A comparative study on the physicochemical characteristics of nanoparticles released in vivo from CoCrMo tapers and cement-stem interfaces of total hip replacements

A comparative study on the physicochemical characteristics of nanoparticles released in vivo from CoCrMo tapers and cement-stem interfaces of total hip replacements
A comparative study on the physicochemical characteristics of nanoparticles released in vivo from CoCrMo tapers and cement-stem interfaces of total hip replacements
The good biocompatibility and corrosion resistance of the bulk CoCrMo alloy has resulted in it being used in the manufacture of implants and load bearing medical devices. These devices, however, can release wear and corrosion products which differ from the composition of the bulk CoCrMo alloy. The physicochemical characteristics of the particles and the associated in-vivo reactivity are dictated by the wear mechanisms and electrochemical conditions at the sites of material loss. Debris released from CoCrMo hip bearings, taper junctions or cement-stem interfaces can therefore have different chemical and morphological characteristics which provides them with different in-vivo toxicities. Here, we propose to assess and compare the characteristics of the particles released in-vivo from CoCrMo tapers and cement-stem interfaces which have received less attention compared to debris originating from the hip bearings. The study uses state-of-art characterisation techniques to provide a detailed understanding of the size, morphology, composition and chemistry of the particles liberated from the wear and corrosion flakes from revised hip replacements, with an enzymatic treatment. The phase analyses identified Cr2O3 nanoparticles released from tapers and cement-stem interfaces, whose composition did not vary with origin or particle morphology. The size distributions showed significantly smaller particles were released from the stems, compared to the particles originating from the corresponding tapers. The investigation demonstrates that the tribocorrosive processes occurring at the taper and stem interfaces both result in Cr2O3 nanoparticle formation.
TEM,, Hip replacements, Orthopaedics,, nanoparticles,, Cobalt Chromium,
1552-4981
Crainic, Alina-Mariana
a8df3e5f-a738-4683-acc8-c75433c88cd0
Callisti, Mauro
b925d711-b012-4c01-8a70-fe7bd59d30c9
Van Veelen, Arjen
cb6f2c8b-4671-4836-88a0-3987fd2f2d67
Michalik, Agnieszka
ab8763a8-8a89-49f0-b6dd-26970e2409ba
Milton, A.
3516eab3-b72f-4b0d-ad30-560f57c94f0d
Palmer, Martin
d2e60e81-5d6e-4ddb-a243-602537286080
Cook, Richard
06f8322d-81be-4f82-9326-19e55541c78f
Crainic, Alina-Mariana
a8df3e5f-a738-4683-acc8-c75433c88cd0
Callisti, Mauro
b925d711-b012-4c01-8a70-fe7bd59d30c9
Van Veelen, Arjen
cb6f2c8b-4671-4836-88a0-3987fd2f2d67
Michalik, Agnieszka
ab8763a8-8a89-49f0-b6dd-26970e2409ba
Milton, A.
3516eab3-b72f-4b0d-ad30-560f57c94f0d
Palmer, Martin
d2e60e81-5d6e-4ddb-a243-602537286080
Cook, Richard
06f8322d-81be-4f82-9326-19e55541c78f

Crainic, Alina-Mariana, Callisti, Mauro, Van Veelen, Arjen, Michalik, Agnieszka, Milton, A., Palmer, Martin and Cook, Richard (2020) A comparative study on the physicochemical characteristics of nanoparticles released in vivo from CoCrMo tapers and cement-stem interfaces of total hip replacements. Journal of Biomedical Materials Research Part B: Applied Biomaterials.

Record type: Article

Abstract

The good biocompatibility and corrosion resistance of the bulk CoCrMo alloy has resulted in it being used in the manufacture of implants and load bearing medical devices. These devices, however, can release wear and corrosion products which differ from the composition of the bulk CoCrMo alloy. The physicochemical characteristics of the particles and the associated in-vivo reactivity are dictated by the wear mechanisms and electrochemical conditions at the sites of material loss. Debris released from CoCrMo hip bearings, taper junctions or cement-stem interfaces can therefore have different chemical and morphological characteristics which provides them with different in-vivo toxicities. Here, we propose to assess and compare the characteristics of the particles released in-vivo from CoCrMo tapers and cement-stem interfaces which have received less attention compared to debris originating from the hip bearings. The study uses state-of-art characterisation techniques to provide a detailed understanding of the size, morphology, composition and chemistry of the particles liberated from the wear and corrosion flakes from revised hip replacements, with an enzymatic treatment. The phase analyses identified Cr2O3 nanoparticles released from tapers and cement-stem interfaces, whose composition did not vary with origin or particle morphology. The size distributions showed significantly smaller particles were released from the stems, compared to the particles originating from the corresponding tapers. The investigation demonstrates that the tribocorrosive processes occurring at the taper and stem interfaces both result in Cr2O3 nanoparticle formation.

Text
J Biomed Mater Res final full - Accepted Manuscript
Restricted to Repository staff only until 28 June 2021.
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More information

Accepted/In Press date: 25 May 2020
e-pub ahead of print date: 28 June 2020
Keywords: TEM,, Hip replacements, Orthopaedics,, nanoparticles,, Cobalt Chromium,

Identifiers

Local EPrints ID: 442632
URI: http://eprints.soton.ac.uk/id/eprint/442632
ISSN: 1552-4981
PURE UUID: eb203a6d-6d0b-4e7c-8d16-232eaefe1638

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Date deposited: 21 Jul 2020 16:34
Last modified: 06 Oct 2020 19:29

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