Fluorinated carbohydrates as chemical probes for molecular recognition studies. Current status and perspectives

Linclau, Bruno, Reichardt, Niels C., Sollogoub, Matthieu, Unione, Luca, Vincent, Stéphane P. and Jiménez-Barbero, Jesús (2020) Fluorinated carbohydrates as chemical probes for molecular recognition studies. Current status and perspectives. Chemical Society Reviews, 49 (12), 3863-3888. (doi:10.1039/C9CS00099B).

Record type: Review

Abstract

This review provides an extensive summary of the effects of carbohydrate fluorination with regard to changes in physical, chemical and biological properties with respect to regular saccharides. The specific structural, conformational, stability, reactivity and interaction features of fluorinated sugars are described, as well as their applications as probes and in chemical biology.

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e-pub ahead of print date: 10 June 2020

Published date: 21 June 2020

Additional Information: Funding Information: Bruno Linclau is Professor of Organic Chemistry at School of Chemistry, University of South ampton. He earned his Licentiate in Sciences (Chemistry) degree from the University of Ghent (Belgium), where he also obtained his PhD in 1996 with Prof. Maurits Vandewalle. He carried out post doctoral research with Professor Dennis P. Curran at the University of Pittsburgh, Pittsburgh PA (USA) with a fellowship from the Belgian American Educational Foundation. He joined the faculty at South ampton University in 1999. Funding Information: B. L. thanks the EPSRC (EP/P019943/1) for funding. L. U. acknowledges funding from the postdoctoral fellowship from the Human Frontier Science Program Organization (HFSP) Grant No. LT000747/2018-C. N. C. R. acknowledges funding from Agencia Estatal de Investigación (Spain) Grant No. CTQ2017-90039-R and RTC-2017-6126-1 and the Maria de Maeztu Units of Excellence Program. MDM-2017-0720. The group at Bilbao thank the Agencia Estatal de Investigacion of Spain (Grant RTI2018-094751-B-C21), the European Research Council (RECGLYCANMR, ERC AdG 788143), and the Severo Ochoa Excellence Accreditation SEV-2016-0644. SV acknowledges funding by FRS-FNRS (PDR grant number T.0102.18). Publisher Copyright: © The Royal Society of Chemistry.

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