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Fluorinated carbohydrates as chemical probes for molecular recognition studies. Current status and perspectives

Fluorinated carbohydrates as chemical probes for molecular recognition studies. Current status and perspectives
Fluorinated carbohydrates as chemical probes for molecular recognition studies. Current status and perspectives
This review provides an extensive summary of the effects of carbohydrate fluorination with regard to changes in physical, chemical and biological properties with respect to regular saccharides. The specific structural, conformational, stability, reactivity and interaction features of fluorinated sugars are described, as well as their applications as probes and in chemical biology.
0306-0012
3863-3888
Linclau, Bruno
19b9cacd-b8e8-4c65-af36-6352cade84ba
Reichardt, Niels C.
00b4a72e-ca65-4ea8-a28c-deb3d8ec65fd
Sollogoub, Matthieu
e9a6b887-5184-49d6-93bf-5a3baf392e2b
Unione, Luca
97ad71bd-c2a8-4e2f-907f-ec1034ec8ded
Vincent, Stéphane P.
b6829417-7dd3-4a22-a884-c0e5c98c67c1
Jiménez-Barbero, Jesús
8d249106-a8a2-40ff-bcf0-e16ee3b75d32
Linclau, Bruno
19b9cacd-b8e8-4c65-af36-6352cade84ba
Reichardt, Niels C.
00b4a72e-ca65-4ea8-a28c-deb3d8ec65fd
Sollogoub, Matthieu
e9a6b887-5184-49d6-93bf-5a3baf392e2b
Unione, Luca
97ad71bd-c2a8-4e2f-907f-ec1034ec8ded
Vincent, Stéphane P.
b6829417-7dd3-4a22-a884-c0e5c98c67c1
Jiménez-Barbero, Jesús
8d249106-a8a2-40ff-bcf0-e16ee3b75d32

Linclau, Bruno, Reichardt, Niels C., Sollogoub, Matthieu, Unione, Luca, Vincent, Stéphane P. and Jiménez-Barbero, Jesús (2020) Fluorinated carbohydrates as chemical probes for molecular recognition studies. Current status and perspectives. Chemical Society Reviews, 49 (12), 3863-3888. (doi:10.1039/C9CS00099B).

Record type: Review

Abstract

This review provides an extensive summary of the effects of carbohydrate fluorination with regard to changes in physical, chemical and biological properties with respect to regular saccharides. The specific structural, conformational, stability, reactivity and interaction features of fluorinated sugars are described, as well as their applications as probes and in chemical biology.

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e-pub ahead of print date: 10 June 2020
Published date: 21 June 2020
Additional Information: Funding Information: Bruno Linclau is Professor of Organic Chemistry at School of Chemistry, University of South ampton. He earned his Licentiate in Sciences (Chemistry) degree from the University of Ghent (Belgium), where he also obtained his PhD in 1996 with Prof. Maurits Vandewalle. He carried out post doctoral research with Professor Dennis P. Curran at the University of Pittsburgh, Pittsburgh PA (USA) with a fellowship from the Belgian American Educational Foundation. He joined the faculty at South ampton University in 1999. Funding Information: B. L. thanks the EPSRC (EP/P019943/1) for funding. L. U. acknowledges funding from the postdoctoral fellowship from the Human Frontier Science Program Organization (HFSP) Grant No. LT000747/2018-C. N. C. R. acknowledges funding from Agencia Estatal de Investigación (Spain) Grant No. CTQ2017-90039-R and RTC-2017-6126-1 and the Maria de Maeztu Units of Excellence Program. MDM-2017-0720. The group at Bilbao thank the Agencia Estatal de Investigacion of Spain (Grant RTI2018-094751-B-C21), the European Research Council (RECGLYCANMR, ERC AdG 788143), and the Severo Ochoa Excellence Accreditation SEV-2016-0644. SV acknowledges funding by FRS-FNRS (PDR grant number T.0102.18). Publisher Copyright: © The Royal Society of Chemistry.

Identifiers

Local EPrints ID: 442822
URI: http://eprints.soton.ac.uk/id/eprint/442822
ISSN: 0306-0012
PURE UUID: 20d3b47c-207b-46cf-a40b-d6cc2c33d8fa
ORCID for Bruno Linclau: ORCID iD orcid.org/0000-0001-8762-0170

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Date deposited: 28 Jul 2020 16:31
Last modified: 17 Mar 2024 02:51

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Contributors

Author: Bruno Linclau ORCID iD
Author: Niels C. Reichardt
Author: Matthieu Sollogoub
Author: Luca Unione
Author: Stéphane P. Vincent
Author: Jesús Jiménez-Barbero

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