Capillary-driven flow microfluidics combined with smartphone detection: an emerging tool for point-of-care diagnostics
Capillary-driven flow microfluidics combined with smartphone detection: an emerging tool for point-of-care diagnostics
Point-of-care (POC) or near-patient testing allows clinicians to accurately achieve real-time diagnostic results performed at or near to the patient site. The outlook of POC devices is to provide quicker analyses that can lead to well-informed clinical decisions and hence improve the health of patients at the point-of-need. Microfluidics plays an important role in the development of POC devices. However, requirements of handling expertise, pumping systems and complex fluidic controls make the technology unaffordable to the current healthcare systems in the world. In recent years, capillary-driven flow microfluidics has emerged as an attractive microfluidic-based technology to overcome these limitations by offering robust, cost-effective and simple-to-operate devices. The internal wall of the microchannels can be pre-coated with reagents, and by merely dipping the device into the patient sample, the sample can be loaded into the microchannel driven by capillary forces and can be detected via handheld or smartphone-based detectors. The capabilities of capillary-driven flow devices have not been fully exploited in developing POC diagnostics, especially for antimicrobial resistance studies in clinical settings. The purpose of this review is to open up this field of microfluidics to the ever-expanding microfluidic-based scientific community.
Antimicrobial resistance, Capillary action, Capillary-driven flow, Detections, Lab-on-a-chip, Microfluidics, Point-of-care diagnostics, Smartphone imaging
Hassan, Sammer-Ul
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Tariq, Aamira
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Noreen, Zobia
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Donia, Ahmed
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Zaidi, Syed Z J
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Bokhari, habib
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Zhang, Xunli
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August 2020
Hassan, Sammer-Ul
8a5ae3f1-3451-4093-879e-85f40953da8b
Tariq, Aamira
4f936c30-424c-4cf6-8f95-cb7e81866140
Noreen, Zobia
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Donia, Ahmed
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Zaidi, Syed Z J
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Bokhari, habib
1c3a1e18-4570-4a10-9feb-cea4218a275f
Zhang, Xunli
d7cf1181-3276-4da1-9150-e212b333abb1
Hassan, Sammer-Ul, Tariq, Aamira, Noreen, Zobia, Donia, Ahmed, Zaidi, Syed Z J, Bokhari, habib and Zhang, Xunli
(2020)
Capillary-driven flow microfluidics combined with smartphone detection: an emerging tool for point-of-care diagnostics.
Diagnostics, 10 (8), [509].
(doi:10.3390/diagnostics10080509).
Abstract
Point-of-care (POC) or near-patient testing allows clinicians to accurately achieve real-time diagnostic results performed at or near to the patient site. The outlook of POC devices is to provide quicker analyses that can lead to well-informed clinical decisions and hence improve the health of patients at the point-of-need. Microfluidics plays an important role in the development of POC devices. However, requirements of handling expertise, pumping systems and complex fluidic controls make the technology unaffordable to the current healthcare systems in the world. In recent years, capillary-driven flow microfluidics has emerged as an attractive microfluidic-based technology to overcome these limitations by offering robust, cost-effective and simple-to-operate devices. The internal wall of the microchannels can be pre-coated with reagents, and by merely dipping the device into the patient sample, the sample can be loaded into the microchannel driven by capillary forces and can be detected via handheld or smartphone-based detectors. The capabilities of capillary-driven flow devices have not been fully exploited in developing POC diagnostics, especially for antimicrobial resistance studies in clinical settings. The purpose of this review is to open up this field of microfluidics to the ever-expanding microfluidic-based scientific community.
Text
diagnostics-10-00509-v2
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More information
Accepted/In Press date: 20 July 2020
Published date: August 2020
Additional Information:
Funding Information:
Funding: We thank the funding from the Economic and Social Research Council UK (ES/S000208/1). HB would like to thank the Higher Education Commission for providing funding to support this work under the grant number NRPU-3470.
Funding Information:
Acknowledgments: The presented study was completed as part of the DOSA Project (Diagnostics for One Health and User Driven Solutions for AMR, www.dosa-diagnostics.org). DOSA is funded by UK Research and Innovation/Economic Social Science Research Council, Newton Fund, and the Government of India’s Department of Biotechnology. We thank the funding from the Economic and Social Research Council UK (ES/S000208/1).
Publisher Copyright:
© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
Keywords:
Antimicrobial resistance, Capillary action, Capillary-driven flow, Detections, Lab-on-a-chip, Microfluidics, Point-of-care diagnostics, Smartphone imaging
Identifiers
Local EPrints ID: 442826
URI: http://eprints.soton.ac.uk/id/eprint/442826
ISSN: 2075-4418
PURE UUID: 31e2c319-4fdf-429d-9d00-b9606b663444
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Date deposited: 28 Jul 2020 16:31
Last modified: 17 Mar 2024 03:10
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Contributors
Author:
Aamira Tariq
Author:
Zobia Noreen
Author:
Ahmed Donia
Author:
Syed Z J Zaidi
Author:
habib Bokhari
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