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Role of deficient type III interferon-? production in asthma exacerbations

Role of deficient type III interferon-? production in asthma exacerbations
Role of deficient type III interferon-? production in asthma exacerbations
Rhinoviruses are the major cause of asthma exacerbations, and asthmatics have increased susceptibility to rhinovirus and risk of invasive bacterial infections. Here we show deficient induction of interferon-?s by rhinovirus in asthmatic primary bronchial epithelial cells and alveolar macrophages, which was highly correlated with severity of rhinovirus-induced asthma exacerbation and virus load in experimentally infected human volunteers. Induction by lipopolysaccharide in asthmatic macrophages was also deficient and correlated with exacerbation severity. These results identify previously unknown mechanisms of susceptibility to infection in asthma and suggest new approaches to prevention and/or treatment of asthma exacerbations.
1078-8956
1023-1026
Contoli, Marco
947b5def-4b23-45f9-be37-5abf7f9ca6b6
Message, Simon D.
8b35aee9-fc2a-4b08-ae8b-fa27b0d5e82b
Laza-Stanca, Vasile
b2753e13-40e9-41d5-8109-995410b75519
Edwards, Michael R.
03036dcc-b9f5-47d3-b44e-912b01754ad3
Wark, Peter A.B.
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Bartlett, Nathan W.
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Kebadze, Tatiana
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Mallia, Patrick
bd47347a-be47-4169-8023-c0ef7b914248
Stanciu, Luminita A.
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Parker, Hayley L.
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Slater, Louise
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Lewis-Antes, Anita
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Kon, Onn M.
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Holgate, Stephen T.
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Davies, Donna E.
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Kotenko, Sergei V.
29957a88-26a4-4f5e-b9a0-36e10692a91c
Papi, Alberto
8447eef8-34fd-482e-8e91-f8231acd05f7
Johnston, Sebastian L.
90e0ef79-cfde-40e0-b301-90d3063ee036
Contoli, Marco
947b5def-4b23-45f9-be37-5abf7f9ca6b6
Message, Simon D.
8b35aee9-fc2a-4b08-ae8b-fa27b0d5e82b
Laza-Stanca, Vasile
b2753e13-40e9-41d5-8109-995410b75519
Edwards, Michael R.
03036dcc-b9f5-47d3-b44e-912b01754ad3
Wark, Peter A.B.
df363708-b8e0-4f92-acd5-8bb7088e19d2
Bartlett, Nathan W.
f2def8c7-14f7-4e28-8259-a9b5f953342c
Kebadze, Tatiana
6f5bb73b-9876-428c-aed5-f0bf2716e492
Mallia, Patrick
bd47347a-be47-4169-8023-c0ef7b914248
Stanciu, Luminita A.
92eb55fa-d20e-4d3a-aa71-207eaf6bceca
Parker, Hayley L.
33375c3b-956b-4030-8495-9ded6537dde3
Slater, Louise
10c50b7c-ae08-445e-b8fb-d815dbe28d58
Lewis-Antes, Anita
8aa13802-5dca-4736-b67a-bc5aef0c4549
Kon, Onn M.
747df390-6138-43ee-b233-6b5c4337334b
Holgate, Stephen T.
2e7c17a9-6796-436e-8772-1fe6d2ac5edc
Davies, Donna E.
7de8fdc7-3640-4e3a-aa91-d0e03f990c38
Kotenko, Sergei V.
29957a88-26a4-4f5e-b9a0-36e10692a91c
Papi, Alberto
8447eef8-34fd-482e-8e91-f8231acd05f7
Johnston, Sebastian L.
90e0ef79-cfde-40e0-b301-90d3063ee036

Contoli, Marco, Message, Simon D., Laza-Stanca, Vasile, Edwards, Michael R., Wark, Peter A.B., Bartlett, Nathan W., Kebadze, Tatiana, Mallia, Patrick, Stanciu, Luminita A., Parker, Hayley L., Slater, Louise, Lewis-Antes, Anita, Kon, Onn M., Holgate, Stephen T., Davies, Donna E., Kotenko, Sergei V., Papi, Alberto and Johnston, Sebastian L. (2006) Role of deficient type III interferon-? production in asthma exacerbations. Nature Medicine, 12 (9), 1023-1026. (doi:10.1038/nm1462).

Record type: Article

Abstract

Rhinoviruses are the major cause of asthma exacerbations, and asthmatics have increased susceptibility to rhinovirus and risk of invasive bacterial infections. Here we show deficient induction of interferon-?s by rhinovirus in asthmatic primary bronchial epithelial cells and alveolar macrophages, which was highly correlated with severity of rhinovirus-induced asthma exacerbation and virus load in experimentally infected human volunteers. Induction by lipopolysaccharide in asthmatic macrophages was also deficient and correlated with exacerbation severity. These results identify previously unknown mechanisms of susceptibility to infection in asthma and suggest new approaches to prevention and/or treatment of asthma exacerbations.

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Published date: 2006
Additional Information: Brief communication

Identifiers

Local EPrints ID: 44289
URI: http://eprints.soton.ac.uk/id/eprint/44289
ISSN: 1078-8956
PURE UUID: fbed6cee-cc37-49c1-b07d-37483eb9ac44
ORCID for Donna E. Davies: ORCID iD orcid.org/0000-0002-5117-2991

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Date deposited: 22 Feb 2007
Last modified: 17 Dec 2019 02:04

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Contributors

Author: Marco Contoli
Author: Simon D. Message
Author: Vasile Laza-Stanca
Author: Michael R. Edwards
Author: Peter A.B. Wark
Author: Nathan W. Bartlett
Author: Tatiana Kebadze
Author: Patrick Mallia
Author: Luminita A. Stanciu
Author: Hayley L. Parker
Author: Louise Slater
Author: Anita Lewis-Antes
Author: Onn M. Kon
Author: Donna E. Davies ORCID iD
Author: Sergei V. Kotenko
Author: Alberto Papi
Author: Sebastian L. Johnston

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