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Role of deficient type III interferon-? production in asthma exacerbations

Contoli, Marco, Message, Simon D., Laza-Stanca, Vasile, Edwards, Michael R., Wark, Peter A.B., Bartlett, Nathan W., Kebadze, Tatiana, Mallia, Patrick, Stanciu, Luminita A., Parker, Hayley L., Slater, Louise, Lewis-Antes, Anita, Kon, Onn M., Holgate, Stephen T., Davies, Donna E., Kotenko, Sergei V., Papi, Alberto and Johnston, Sebastian L. (2006) Role of deficient type III interferon-? production in asthma exacerbations Nature Medicine, 12, (9), pp. 1023-1026. (doi:10.1038/nm1462).

Record type: Article

Abstract

Rhinoviruses are the major cause of asthma exacerbations, and asthmatics have increased susceptibility to rhinovirus and risk of invasive bacterial infections. Here we show deficient induction of interferon-?s by rhinovirus in asthmatic primary bronchial epithelial cells and alveolar macrophages, which was highly correlated with severity of rhinovirus-induced asthma exacerbation and virus load in experimentally infected human volunteers. Induction by lipopolysaccharide in asthmatic macrophages was also deficient and correlated with exacerbation severity. These results identify previously unknown mechanisms of susceptibility to infection in asthma and suggest new approaches to prevention and/or treatment of asthma exacerbations.

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Published date: 2006
Additional Information: Brief communication

Identifiers

Local EPrints ID: 44289
URI: http://eprints.soton.ac.uk/id/eprint/44289
ISSN: 1078-8956
PURE UUID: fbed6cee-cc37-49c1-b07d-37483eb9ac44

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Date deposited: 22 Feb 2007
Last modified: 17 Jul 2017 15:15

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Contributors

Author: Marco Contoli
Author: Simon D. Message
Author: Vasile Laza-Stanca
Author: Michael R. Edwards
Author: Peter A.B. Wark
Author: Nathan W. Bartlett
Author: Tatiana Kebadze
Author: Patrick Mallia
Author: Luminita A. Stanciu
Author: Hayley L. Parker
Author: Louise Slater
Author: Anita Lewis-Antes
Author: Onn M. Kon
Author: Donna E. Davies
Author: Sergei V. Kotenko
Author: Alberto Papi
Author: Sebastian L. Johnston

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