Von Willebrand factor - two sides and the edge of a coin
Von Willebrand factor - two sides and the edge of a coin
Von Willebrand factor (VWF) has multiple functions in coagulation. It is a clotting protein and its deficiency causes a primary haemostatic bleeding disorder. Excess VWF, particularly high molecular weight multimers can cause thrombosis. There is also a debatable function of protecting factor VIII (FVIII) in circulation with the prevention of development of FVIII inhibitors. This commentary addresses these functions.
ADAMTS13, Bleeding, Factor VIII inhibitors, Laboratory measurements, Thrombosis
61-64
Rangarajan, S.
9a5e4c7e-55ba-4a3a-b5f6-f1e269d927c3
January 2011
Rangarajan, S.
9a5e4c7e-55ba-4a3a-b5f6-f1e269d927c3
Abstract
Von Willebrand factor (VWF) has multiple functions in coagulation. It is a clotting protein and its deficiency causes a primary haemostatic bleeding disorder. Excess VWF, particularly high molecular weight multimers can cause thrombosis. There is also a debatable function of protecting factor VIII (FVIII) in circulation with the prevention of development of FVIII inhibitors. This commentary addresses these functions.
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Accepted/In Press date: 15 April 2010
e-pub ahead of print date: 29 December 2010
Published date: January 2011
Keywords:
ADAMTS13, Bleeding, Factor VIII inhibitors, Laboratory measurements, Thrombosis
Identifiers
Local EPrints ID: 442899
URI: http://eprints.soton.ac.uk/id/eprint/442899
ISSN: 1351-8216
PURE UUID: c53d9d5c-5c17-4ac3-b0b6-067b27ae11b8
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Date deposited: 30 Jul 2020 16:34
Last modified: 17 Mar 2024 04:02
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