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Von Willebrand factor - two sides and the edge of a coin

Von Willebrand factor - two sides and the edge of a coin
Von Willebrand factor - two sides and the edge of a coin

Von Willebrand factor (VWF) has multiple functions in coagulation. It is a clotting protein and its deficiency causes a primary haemostatic bleeding disorder. Excess VWF, particularly high molecular weight multimers can cause thrombosis. There is also a debatable function of protecting factor VIII (FVIII) in circulation with the prevention of development of FVIII inhibitors. This commentary addresses these functions.

ADAMTS13, Bleeding, Factor VIII inhibitors, Laboratory measurements, Thrombosis
1351-8216
61-64
Rangarajan, S.
9a5e4c7e-55ba-4a3a-b5f6-f1e269d927c3
Rangarajan, S.
9a5e4c7e-55ba-4a3a-b5f6-f1e269d927c3

Rangarajan, S. (2011) Von Willebrand factor - two sides and the edge of a coin. Haemophilia, 17 (1), 61-64. (doi:10.1111/j.1365-2516.2010.02323.x).

Record type: Article

Abstract

Von Willebrand factor (VWF) has multiple functions in coagulation. It is a clotting protein and its deficiency causes a primary haemostatic bleeding disorder. Excess VWF, particularly high molecular weight multimers can cause thrombosis. There is also a debatable function of protecting factor VIII (FVIII) in circulation with the prevention of development of FVIII inhibitors. This commentary addresses these functions.

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More information

Accepted/In Press date: 15 April 2010
e-pub ahead of print date: 29 December 2010
Published date: January 2011
Keywords: ADAMTS13, Bleeding, Factor VIII inhibitors, Laboratory measurements, Thrombosis

Identifiers

Local EPrints ID: 442899
URI: http://eprints.soton.ac.uk/id/eprint/442899
ISSN: 1351-8216
PURE UUID: c53d9d5c-5c17-4ac3-b0b6-067b27ae11b8
ORCID for S. Rangarajan: ORCID iD orcid.org/0000-0001-7367-133X

Catalogue record

Date deposited: 30 Jul 2020 16:34
Last modified: 17 Mar 2024 04:02

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