The role of antigen presentation in tumor-associated macrophages
The role of antigen presentation in tumor-associated macrophages
Macrophages are cells of the myeloid lineage with important roles not only in immune regulation and tissue repair, but also in pathological states such as autoimmune disease and cancer. A plethora of macrophage subtypes exist with distinct phenotypes and functions, not least within the tumor microenvironment (TME) of solid tumors. The abundant macrophages located within the TME are often referred to as tumor-associated macrophages (TAMs). TAMs may be pro-inflammatory with antitumor properties, or may have pro-tumor functions such as angiogenesis. Typically, TAMs are endowed with pro-tumor phenotypes, which has led to strategies to deplete or reprogram TAMs within the TME. Although historically recognized as professional antigen presenting cells (APCs), macrophages are often considered inferior in their abilities to process and present antigens in comparison with dendritic cells (DCs). Notwithstanding, this review gives an overview of the potential accessory role that macrophages might have in antigen processing and presentation to T cells within the TME, with implications for the design of novel immunotherapies.
Antigen presen-tation, Fc gamma receptor, Immunoglobulin G, Macrophage, Major histocompatibility complex, Monoclonal antibody, Neonatal Fc receptor, Phagocytosis, Tumor microenvironment, Tumor-associated macrophage
205-224
Stopforth, Richard
2d3e18ff-5563-4247-9150-f0f337fb585f
Ward, E. Sally
b31c0877-8abe-485f-b800-244a9d3cd6cc
December 2020
Stopforth, Richard
2d3e18ff-5563-4247-9150-f0f337fb585f
Ward, E. Sally
b31c0877-8abe-485f-b800-244a9d3cd6cc
Stopforth, Richard and Ward, E. Sally
(2020)
The role of antigen presentation in tumor-associated macrophages.
Critical Reviews in Immunology, 40 (3), .
(doi:10.1615/CritRevImmunol.2020034910).
Abstract
Macrophages are cells of the myeloid lineage with important roles not only in immune regulation and tissue repair, but also in pathological states such as autoimmune disease and cancer. A plethora of macrophage subtypes exist with distinct phenotypes and functions, not least within the tumor microenvironment (TME) of solid tumors. The abundant macrophages located within the TME are often referred to as tumor-associated macrophages (TAMs). TAMs may be pro-inflammatory with antitumor properties, or may have pro-tumor functions such as angiogenesis. Typically, TAMs are endowed with pro-tumor phenotypes, which has led to strategies to deplete or reprogram TAMs within the TME. Although historically recognized as professional antigen presenting cells (APCs), macrophages are often considered inferior in their abilities to process and present antigens in comparison with dendritic cells (DCs). Notwithstanding, this review gives an overview of the potential accessory role that macrophages might have in antigen processing and presentation to T cells within the TME, with implications for the design of novel immunotherapies.
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Accepted/In Press date: 23 July 2020
Published date: December 2020
Keywords:
Antigen presen-tation, Fc gamma receptor, Immunoglobulin G, Macrophage, Major histocompatibility complex, Monoclonal antibody, Neonatal Fc receptor, Phagocytosis, Tumor microenvironment, Tumor-associated macrophage
Identifiers
Local EPrints ID: 442934
URI: http://eprints.soton.ac.uk/id/eprint/442934
ISSN: 1040-8401
PURE UUID: 4e33a0ea-1341-41b7-a5b1-245f3df628b0
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Date deposited: 03 Aug 2020 16:30
Last modified: 17 Mar 2024 05:48
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Author:
Richard Stopforth
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