The role of pre-clinical 3-dimensional models of osteosarcoma
The role of pre-clinical 3-dimensional models of osteosarcoma
Treatment for osteosarcoma (OS) has been largely unchanged for several decades, with typical therapies being a mixture of chemotherapy and surgery. Although therapeutic targets and products against cancer are being continually developed, only a limited number have proved therapeutically active in OS. Thus, the understanding of the OS microenvironment and its interactions are becoming more important in developing new therapies. Three-dimensional (3D) models are important tools in increasing our understanding of complex mechanisms and interactions, such as in OS. In this review, in vivo animal models, in vitro 3D models and in ovo chorioallantoic membrane (CAM) models, are evaluated and discussed as to their contribution in understanding the progressive nature of OS, and cancer research. We aim to provide insight and prospective future directions into the potential translation of 3D models in OS.
3D model, Ex vivo, In ovo, In vivo, Osteosarcoma
1-12
Smith, Hannah
e97b320e-8bee-4b80-84e5-d7da65e1e723
Beers, Stephen
a02548be-3ffd-41ab-9db8-d6e8c3b499a2
Gray, Juliet
12d5e17c-97bb-4d6d-8fc4-3914b730ed42
Kanczler, Janos
eb8db9ff-a038-475f-9030-48eef2b0559c
1 August 2020
Smith, Hannah
e97b320e-8bee-4b80-84e5-d7da65e1e723
Beers, Stephen
a02548be-3ffd-41ab-9db8-d6e8c3b499a2
Gray, Juliet
12d5e17c-97bb-4d6d-8fc4-3914b730ed42
Kanczler, Janos
eb8db9ff-a038-475f-9030-48eef2b0559c
Smith, Hannah, Beers, Stephen, Gray, Juliet and Kanczler, Janos
(2020)
The role of pre-clinical 3-dimensional models of osteosarcoma.
International Journal of Molecular Sciences, 21 (15), , [5499].
(doi:10.3390/ijms21155499).
Abstract
Treatment for osteosarcoma (OS) has been largely unchanged for several decades, with typical therapies being a mixture of chemotherapy and surgery. Although therapeutic targets and products against cancer are being continually developed, only a limited number have proved therapeutically active in OS. Thus, the understanding of the OS microenvironment and its interactions are becoming more important in developing new therapies. Three-dimensional (3D) models are important tools in increasing our understanding of complex mechanisms and interactions, such as in OS. In this review, in vivo animal models, in vitro 3D models and in ovo chorioallantoic membrane (CAM) models, are evaluated and discussed as to their contribution in understanding the progressive nature of OS, and cancer research. We aim to provide insight and prospective future directions into the potential translation of 3D models in OS.
Text
ijms-21-05499-v2
- Version of Record
More information
Accepted/In Press date: 30 July 2020
Published date: 1 August 2020
Additional Information:
Funding Information:
Funding: Hannah’s Willberry Wonder Pony Charity and a Southampton funded this research.
Publisher Copyright:
© 2020 by the authors. Licensee MDPI, Basel, Switzerland.
Keywords:
3D model, Ex vivo, In ovo, In vivo, Osteosarcoma
Identifiers
Local EPrints ID: 442987
URI: http://eprints.soton.ac.uk/id/eprint/442987
ISSN: 1422-0067
PURE UUID: dddfe3b6-0b9c-4680-b1f3-e79af621ba62
Catalogue record
Date deposited: 05 Aug 2020 16:30
Last modified: 17 Mar 2024 03:47
Export record
Altmetrics
Contributors
Author:
Hannah Smith
Author:
Janos Kanczler
Download statistics
Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.
View more statistics