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Layered polymer - inorganic composite waveguides for biosensor applications

Layered polymer - inorganic composite waveguides for biosensor applications
Layered polymer - inorganic composite waveguides for biosensor applications
In this work, we investigate the usability of layered polymer - inorganic composite waveguides for label-free sensing of surface bound bioreactions in an aqueous environment. The waveguide structure consists of a nanoimprint fabricated polymeric inverted rib waveguide with a sputtered Ta2O5 thin film on top. The interaction of the optical field with the surface is increased as a consequence of the mode profile localization near the surface, when high-index coating is deposited on a low-index waveguide. Young interferometer configuration with reference and sensors waveguide arms was utilized in sensor chips. Light from a laser source was end-fire coupled into the chips and interference pattern produced by the outcoupled light was investigated. External µ-fluidic pump was used to produce the analyte flow. Ambient refractive index change was characterized by applying DI-water with varying glucose concentration on waveguides. With the waveguide length of 1 cm a detection limit in the order of 10-7 - 10-6 refractive index unit (RIU) was achieved. Specific binding reactions on the surface were investigated with C - reactive protein (CRP) antibodies and antigens.
Hiltunen, Jussi
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Wang, Meng
a0288ea3-040e-4f92-8acb-d3f27b22b7b6
Liedert, Christina
43d5f52e-8e2d-4271-a26e-164f13df2559
Aikio, Sanna
37a71589-1e52-460f-83d7-1b6e6dffe913
Masuda, Noriyuki
397efb94-8e32-4032-bd22-ca3a5dcac2ee
Pearce, Stuart
1d0ee7c5-8f72-4783-a034-9b2f67de3531
Charlton, Martin
fcf86ab0-8f34-411a-b576-4f684e51e274
Karioja, Pentti
5e3e7ea3-7c69-40a8-afa5-fe1895716a9e
Hiltunen, Jussi
cf4de971-1190-45ee-8809-c31cb8b4b8f4
Wang, Meng
a0288ea3-040e-4f92-8acb-d3f27b22b7b6
Liedert, Christina
43d5f52e-8e2d-4271-a26e-164f13df2559
Aikio, Sanna
37a71589-1e52-460f-83d7-1b6e6dffe913
Masuda, Noriyuki
397efb94-8e32-4032-bd22-ca3a5dcac2ee
Pearce, Stuart
1d0ee7c5-8f72-4783-a034-9b2f67de3531
Charlton, Martin
fcf86ab0-8f34-411a-b576-4f684e51e274
Karioja, Pentti
5e3e7ea3-7c69-40a8-afa5-fe1895716a9e

Hiltunen, Jussi, Wang, Meng, Liedert, Christina, Aikio, Sanna, Masuda, Noriyuki, Pearce, Stuart, Charlton, Martin and Karioja, Pentti (2012) Layered polymer - inorganic composite waveguides for biosensor applications. Photonics Europe: SPIE 8427: Progress in Biomedical Optics and Imaging, Belgium. 16 - 19 Apr 2012. 6 pp . (doi:10.1117/12.922267).

Record type: Conference or Workshop Item (Paper)

Abstract

In this work, we investigate the usability of layered polymer - inorganic composite waveguides for label-free sensing of surface bound bioreactions in an aqueous environment. The waveguide structure consists of a nanoimprint fabricated polymeric inverted rib waveguide with a sputtered Ta2O5 thin film on top. The interaction of the optical field with the surface is increased as a consequence of the mode profile localization near the surface, when high-index coating is deposited on a low-index waveguide. Young interferometer configuration with reference and sensors waveguide arms was utilized in sensor chips. Light from a laser source was end-fire coupled into the chips and interference pattern produced by the outcoupled light was investigated. External µ-fluidic pump was used to produce the analyte flow. Ambient refractive index change was characterized by applying DI-water with varying glucose concentration on waveguides. With the waveguide length of 1 cm a detection limit in the order of 10-7 - 10-6 refractive index unit (RIU) was achieved. Specific binding reactions on the surface were investigated with C - reactive protein (CRP) antibodies and antigens.

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More information

Published date: 8 May 2012
Venue - Dates: Photonics Europe: SPIE 8427: Progress in Biomedical Optics and Imaging, Belgium, 2012-04-16 - 2012-04-19

Identifiers

Local EPrints ID: 443026
URI: http://eprints.soton.ac.uk/id/eprint/443026
PURE UUID: 9f605193-e00e-45c4-ab96-02625a3a6529

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Date deposited: 06 Aug 2020 16:36
Last modified: 19 Aug 2020 16:32

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Contributors

Author: Jussi Hiltunen
Author: Meng Wang
Author: Christina Liedert
Author: Sanna Aikio
Author: Noriyuki Masuda
Author: Stuart Pearce
Author: Martin Charlton
Author: Pentti Karioja

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