The University of Southampton
University of Southampton Institutional Repository

Development of molecularly imprinted co-polymeric devices for controlled delivery of flufenamic acid using supercritical fluid technology

Development of molecularly imprinted co-polymeric devices for controlled delivery of flufenamic acid using supercritical fluid technology
Development of molecularly imprinted co-polymeric devices for controlled delivery of flufenamic acid using supercritical fluid technology
This work reports the development of a novel class of affinity co-polymeric materials using supercritical fluid technology. Polymeric materials with molecular recognition to flufenamic acid, were first synthesized in supercritical carbon dioxide (scCO2) using the drug as template. Molecularly imprinted co-polymers of methacrylic acid (MAA) or N-isopropyl acrylamide (NIPAAm) crosslinked with ethylene glycol dimethacrylate (EGDMA) were synthesized using different crosslinking degrees and template:monomer ratios, at 65 °C and 21 MPa. High-pressure NMR experiments confirmed that the nature of the interactions between the drug and the functional monomers during the polymerization step are mainly hydrogen bonds. scCO2-assisted impregnation revealed that the imprinted matrices were able to uptake higher amounts of flufenamic acid. This effect was particularly evidenced in the more crosslinked matrices, with P(MAA–EGDMA) imprinted copolymers binding up to 101.5 mg drug/g polymer against only 50.5 mg/g in the non-imprinted copolymer. In vitro drug delivery experiments showed that imprinted co-polymers release the drug in a more sustained way than the corresponding non-imprinted matrices. Overall it was shown that supercritical fluid technology is a viable approach for the development of self-assembly molecular recognition polymers with potential application in controlled drug delivery systems.
0896-8446
150-157
Silva, M.
ab3f6e6f-5d71-44bb-86e6-5ec18388f79e
Luzia De Nobrega, F.
6532795d-88a4-4f05-9b26-6af5b8f21a0d
Cabrita, E.J.
027baca3-4d42-4d1e-90e1-571d5cbeb5ac
Casimiro, T.
0a8b3089-f81b-431c-a55a-d296448f5955
Aguiar-Ricardo, A.
0d48156e-393f-4af3-a43c-e29335e827fd
Silva, M.
ab3f6e6f-5d71-44bb-86e6-5ec18388f79e
Luzia De Nobrega, F.
6532795d-88a4-4f05-9b26-6af5b8f21a0d
Cabrita, E.J.
027baca3-4d42-4d1e-90e1-571d5cbeb5ac
Casimiro, T.
0a8b3089-f81b-431c-a55a-d296448f5955
Aguiar-Ricardo, A.
0d48156e-393f-4af3-a43c-e29335e827fd

Silva, M., Luzia De Nobrega, F., Cabrita, E.J., Casimiro, T. and Aguiar-Ricardo, A. (2011) Development of molecularly imprinted co-polymeric devices for controlled delivery of flufenamic acid using supercritical fluid technology. The Journal of Supercritical Fluids, 58 (1), 150-157. (doi:10.1016/j.supflu.2011.05.010).

Record type: Article

Abstract

This work reports the development of a novel class of affinity co-polymeric materials using supercritical fluid technology. Polymeric materials with molecular recognition to flufenamic acid, were first synthesized in supercritical carbon dioxide (scCO2) using the drug as template. Molecularly imprinted co-polymers of methacrylic acid (MAA) or N-isopropyl acrylamide (NIPAAm) crosslinked with ethylene glycol dimethacrylate (EGDMA) were synthesized using different crosslinking degrees and template:monomer ratios, at 65 °C and 21 MPa. High-pressure NMR experiments confirmed that the nature of the interactions between the drug and the functional monomers during the polymerization step are mainly hydrogen bonds. scCO2-assisted impregnation revealed that the imprinted matrices were able to uptake higher amounts of flufenamic acid. This effect was particularly evidenced in the more crosslinked matrices, with P(MAA–EGDMA) imprinted copolymers binding up to 101.5 mg drug/g polymer against only 50.5 mg/g in the non-imprinted copolymer. In vitro drug delivery experiments showed that imprinted co-polymers release the drug in a more sustained way than the corresponding non-imprinted matrices. Overall it was shown that supercritical fluid technology is a viable approach for the development of self-assembly molecular recognition polymers with potential application in controlled drug delivery systems.

This record has no associated files available for download.

More information

Accepted/In Press date: 16 May 2011
e-pub ahead of print date: 24 May 2011
Published date: August 2011

Identifiers

Local EPrints ID: 443066
URI: http://eprints.soton.ac.uk/id/eprint/443066
ISSN: 0896-8446
PURE UUID: 5023a32c-e8ad-4c74-8239-fe8fa3c3d682
ORCID for F. Luzia De Nobrega: ORCID iD orcid.org/0000-0002-8238-1083

Catalogue record

Date deposited: 10 Aug 2020 16:30
Last modified: 17 Mar 2024 04:02

Export record

Altmetrics

Contributors

Author: M. Silva
Author: E.J. Cabrita
Author: T. Casimiro
Author: A. Aguiar-Ricardo

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×