Revisiting phage therapy: new applications for old resources
Revisiting phage therapy: new applications for old resources
The success of phage therapy is dependent on the development of strategies able to overcome the limitations of bacteriophages as therapeutic agents, the creation of an adequate regulatory framework, the implementation of safety protocols, and acceptance by the general public. Many approaches have been proposed to circumvent phages’ intrinsic limitations but none have proved to be completely satisfactory. In this review we present the major hurdles of phage therapy and the solutions proposed to circumvent them. A thorough discussion of the advantages and drawbacks of these solutions is provided and special attention is given to the genetic modification of phages as an achievable strategy to shape bacteriophages to exhibit desirable biological properties.
185-191
Luzia De Nobrega, Franklin
6532795d-88a4-4f05-9b26-6af5b8f21a0d
Costa, Ana Rita
a1d2b803-b767-4418-a21c-516671e9b40d
Kluskens, Leon
12623693-d537-4522-8369-3cbe51f59ee3
Azeredo, Joana
0e6aef86-c71c-4b48-a071-0c7cc93fe042
April 2015
Luzia De Nobrega, Franklin
6532795d-88a4-4f05-9b26-6af5b8f21a0d
Costa, Ana Rita
a1d2b803-b767-4418-a21c-516671e9b40d
Kluskens, Leon
12623693-d537-4522-8369-3cbe51f59ee3
Azeredo, Joana
0e6aef86-c71c-4b48-a071-0c7cc93fe042
Luzia De Nobrega, Franklin, Costa, Ana Rita, Kluskens, Leon and Azeredo, Joana
(2015)
Revisiting phage therapy: new applications for old resources.
Trends in Microbiology, 23 (4), .
(doi:10.1016/j.tim.2015.01.006).
Abstract
The success of phage therapy is dependent on the development of strategies able to overcome the limitations of bacteriophages as therapeutic agents, the creation of an adequate regulatory framework, the implementation of safety protocols, and acceptance by the general public. Many approaches have been proposed to circumvent phages’ intrinsic limitations but none have proved to be completely satisfactory. In this review we present the major hurdles of phage therapy and the solutions proposed to circumvent them. A thorough discussion of the advantages and drawbacks of these solutions is provided and special attention is given to the genetic modification of phages as an achievable strategy to shape bacteriophages to exhibit desirable biological properties.
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e-pub ahead of print date: 21 February 2015
Published date: April 2015
Identifiers
Local EPrints ID: 443071
URI: http://eprints.soton.ac.uk/id/eprint/443071
ISSN: 0966-842X
PURE UUID: fd8b1009-adaf-49e3-bbc4-498f16691bc8
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Date deposited: 10 Aug 2020 16:30
Last modified: 17 Mar 2024 04:02
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Author:
Ana Rita Costa
Author:
Leon Kluskens
Author:
Joana Azeredo
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