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Targeting mechanisms of tailed bacteriophages

Targeting mechanisms of tailed bacteriophages
Targeting mechanisms of tailed bacteriophages
Phages differ substantially in the bacterial hosts that they infect. Their host range is determined by the specific structures that they use to target bacterial cells. Tailed phages use a broad range of receptor-binding proteins, such as tail fibres, tail spikes and the central tail spike, to target their cognate bacterial cell surface receptors. Recent technical advances and new structure–function insights have begun to unravel the molecular mechanisms and temporal dynamics that govern these interactions. Here, we review the current understanding of the targeting machinery and mechanisms of tailed phages. These new insights and approaches pave the way for the application of phages in medicine and biotechnology and enable deeper understanding of their ecology and evolution.
1740-1526
760-773
Luzia De Nobrega, Franklin
6532795d-88a4-4f05-9b26-6af5b8f21a0d
Vlot, Marnix
2d5d88fc-6116-46b5-a4f7-1d1864976e68
de Jonge, Patrick A
688a0bcd-2b5d-45e3-835c-a06e15484ed6
Dreesens, Lisa L
45c2ec89-4500-468f-885a-ab17d0f0d800
Beaumont, Hubertus J E
af612841-1f73-4424-9534-f475f76f6e70
Lavigne, Rob
f5a2c9c0-00b6-4968-877c-f6352b57b7cd
Dutilh, Bas E.
c570f46e-01cb-4c4a-a9bb-3d39b0815106
Brouns, Stan J J
b9c93a6a-120b-476b-8394-048e41d8ae79
Luzia De Nobrega, Franklin
6532795d-88a4-4f05-9b26-6af5b8f21a0d
Vlot, Marnix
2d5d88fc-6116-46b5-a4f7-1d1864976e68
de Jonge, Patrick A
688a0bcd-2b5d-45e3-835c-a06e15484ed6
Dreesens, Lisa L
45c2ec89-4500-468f-885a-ab17d0f0d800
Beaumont, Hubertus J E
af612841-1f73-4424-9534-f475f76f6e70
Lavigne, Rob
f5a2c9c0-00b6-4968-877c-f6352b57b7cd
Dutilh, Bas E.
c570f46e-01cb-4c4a-a9bb-3d39b0815106
Brouns, Stan J J
b9c93a6a-120b-476b-8394-048e41d8ae79

Luzia De Nobrega, Franklin, Vlot, Marnix, de Jonge, Patrick A, Dreesens, Lisa L, Beaumont, Hubertus J E, Lavigne, Rob, Dutilh, Bas E. and Brouns, Stan J J (2018) Targeting mechanisms of tailed bacteriophages. Nature Reviews Microbiology, 16, 760-773. (doi:10.1038/s41579-018-0070-8).

Record type: Review

Abstract

Phages differ substantially in the bacterial hosts that they infect. Their host range is determined by the specific structures that they use to target bacterial cells. Tailed phages use a broad range of receptor-binding proteins, such as tail fibres, tail spikes and the central tail spike, to target their cognate bacterial cell surface receptors. Recent technical advances and new structure–function insights have begun to unravel the molecular mechanisms and temporal dynamics that govern these interactions. Here, we review the current understanding of the targeting machinery and mechanisms of tailed phages. These new insights and approaches pave the way for the application of phages in medicine and biotechnology and enable deeper understanding of their ecology and evolution.

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More information

e-pub ahead of print date: 13 August 2018
Published date: December 2018

Identifiers

Local EPrints ID: 443082
URI: http://eprints.soton.ac.uk/id/eprint/443082
ISSN: 1740-1526
PURE UUID: baf2cbec-a33f-470a-8bd7-322f30216bae

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Date deposited: 10 Aug 2020 16:30
Last modified: 20 Aug 2020 16:33

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Contributors

Author: Marnix Vlot
Author: Patrick A de Jonge
Author: Lisa L Dreesens
Author: Hubertus J E Beaumont
Author: Rob Lavigne
Author: Bas E. Dutilh
Author: Stan J J Brouns

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