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Easily fabricated monolithic fluoropolymer chips for sensitive long-term absorbance measurement in droplet microfluidics

Easily fabricated monolithic fluoropolymer chips for sensitive long-term absorbance measurement in droplet microfluidics
Easily fabricated monolithic fluoropolymer chips for sensitive long-term absorbance measurement in droplet microfluidics
Maintaining a hydrophobic channel surface is critical to ensuring long term-stable flow in droplet microfluidics. Monolithic fluoropolymer chips ensure robust and reliable droplet flow as their native fluorous surfaces naturally preferentially wet fluorocarbon oils and don’t deteriorate over time. Their fabrication, however, typically requires expensive heated hydraulic presses that make them inaccessible to many laboratories. Here we describe a method for micropatterning and bonding monolithic fluoropolymer flow cells from a commercially available melt-processable fluoropolymer, Dyneon THV 500GZ, that only requires a standard laboratory oven. Using this technique, we demonstrate the formation of complex microstructures, specifically the fabrication of sensitive absorbance flow cells for probing droplets in flow, featuring path lengths up to 10 mm. The native fluorous channel surface means the flow cells can be operated over extended periods, demonstrated by running droplets continuously through a chip for 16 weeks.
2046-2069
30975-30981
Nightingale, Adrian
4b51311d-c6c3-40d5-a13f-ab8917031ab3
Hassan, Sammer-Ul
8a5ae3f1-3451-4093-879e-85f40953da8b
Makris, Kyriacos
e86a7750-ce44-4256-9fc7-e9fd4035fbbf
Bhuiyan, Wahida Taskin
726b7804-d43d-4516-b7e5-e63f60f03135
Harvey, Terence
3b94322b-18da-4de8-b1af-56d202677e04
Niu, Xize
f3d964fb-23b4-45db-92fe-02426e4e76fa
Nightingale, Adrian
4b51311d-c6c3-40d5-a13f-ab8917031ab3
Hassan, Sammer-Ul
8a5ae3f1-3451-4093-879e-85f40953da8b
Makris, Kyriacos
e86a7750-ce44-4256-9fc7-e9fd4035fbbf
Bhuiyan, Wahida Taskin
726b7804-d43d-4516-b7e5-e63f60f03135
Harvey, Terence
3b94322b-18da-4de8-b1af-56d202677e04
Niu, Xize
f3d964fb-23b4-45db-92fe-02426e4e76fa

Nightingale, Adrian, Hassan, Sammer-Ul, Makris, Kyriacos, Bhuiyan, Wahida Taskin, Harvey, Terence and Niu, Xize (2020) Easily fabricated monolithic fluoropolymer chips for sensitive long-term absorbance measurement in droplet microfluidics. RSC Advances, 10 (51), 30975-30981. (doi:10.1039/D0RA05330A).

Record type: Article

Abstract

Maintaining a hydrophobic channel surface is critical to ensuring long term-stable flow in droplet microfluidics. Monolithic fluoropolymer chips ensure robust and reliable droplet flow as their native fluorous surfaces naturally preferentially wet fluorocarbon oils and don’t deteriorate over time. Their fabrication, however, typically requires expensive heated hydraulic presses that make them inaccessible to many laboratories. Here we describe a method for micropatterning and bonding monolithic fluoropolymer flow cells from a commercially available melt-processable fluoropolymer, Dyneon THV 500GZ, that only requires a standard laboratory oven. Using this technique, we demonstrate the formation of complex microstructures, specifically the fabrication of sensitive absorbance flow cells for probing droplets in flow, featuring path lengths up to 10 mm. The native fluorous channel surface means the flow cells can be operated over extended periods, demonstrated by running droplets continuously through a chip for 16 weeks.

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More information

Accepted/In Press date: 21 July 2020
e-pub ahead of print date: 21 August 2020
Published date: 2020

Identifiers

Local EPrints ID: 443274
URI: http://eprints.soton.ac.uk/id/eprint/443274
ISSN: 2046-2069
PURE UUID: fc6abd51-df32-42ee-97df-355317f472be
ORCID for Sammer-Ul Hassan: ORCID iD orcid.org/0000-0002-0319-5814

Catalogue record

Date deposited: 19 Aug 2020 16:32
Last modified: 25 Nov 2021 17:43

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Contributors

Author: Kyriacos Makris
Author: Terence Harvey
Author: Xize Niu

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