The University of Southampton
University of Southampton Institutional Repository
Warning ePrints Soton is experiencing an issue with some file downloads not being available. We are working hard to fix this. Please bear with us.

Factors associated with functional decline in hand and hip/knee osteoarthritis after a year’s time: data from the eposa study

Factors associated with functional decline in hand and hip/knee osteoarthritis after a year’s time: data from the eposa study
Factors associated with functional decline in hand and hip/knee osteoarthritis after a year’s time: data from the eposa study
Objective: the study investigated factors that together with hand or hip/knee osteoarthritis (OA) could contribute to functional decline over a year’s time in elderly individuals.

Methods: the data of 1,886 individuals between the ages of 65‐85 in a prospective, observational population‐based study with 12‐18 month follow‐up in the context of the European Project on OSteoArthritis were analyzed. The outcome measures were self‐reported hand and hip/knee functional decline evaluated using a Minimal Clinically Important Difference of 4 on the AUStralian/CANadian hand OA Index and of 2 on the Western Ontario and McMaster Universities hip/knee OA physical function subscales, both normalized to 0‐100. Using regression models adjusted for sex, age, country, and education level, the baseline factors considered were: clinical hand or hip/knee OA, pain, analgesic/anti‐inflammatory medications, comorbidities, social isolation, income, walking time, grip strength, physical activity time, and medical/social care.

Results: after a year, 453 participants were identified as having “worse” hand functionality and 1,389 as “not worse”. Hand OA, anxiety, walking time and grip strength were risk factors for hand functional decline; pain was a confounder of the effect of hand OA.

Analgesic/anti‐inflammatory medications mediated the combined effect of hip/knee OA+pain on functional decline in the 554 individuals classified as having “worse” hip/knee functionality and the 1,291 “not worse” persons. Peripheral artery disease, obesity, and cognitive impairment were other baseline risk factors.

Conclusion: study findings showed that together with emotional status, chronic physical and cognitive conditions, OA affects hand and hip/knee functional decline.
0893-7524
Siviero, Paolo
8b9e9045-b666-4f5f-9d24-6ff3f00d70d8
Limongi, Federica
1e97a365-9c0d-42e9-9435-6c02a13003f0
Gesmundo, Antonella
7cacaafd-5c5b-4720-809a-1cba3bf9f1d2
Zambon, Sabina
d866a206-bf2e-4651-b50e-06bc450a64a0
Cooper, Cyrus
e05f5612-b493-4273-9b71-9e0ce32bdad6
Dennison, Elaine
ee647287-edb4-4392-8361-e59fd505b1d1
Edwards, Mark
06c1db44-4341-455e-8812-0ab4a1043828
van der Pas, Suzan
eeed262d-8106-4a78-8439-826b2d99bc78
Timmermans, Erik J.
0ebf8273-3f05-4925-bb79-f7db1b55dd29
van Schoor, Natasja M.
3a59a196-b132-414f-81de-2ad3b21f7a74
Schaap, Laura A.
b1b7ece4-8c4f-40af-b98a-9d21075fc6ce
Dallmeier, Dhayana
4c42ca12-bdda-4321-8158-8284af7f2bd1
Denkinger, Michael D.
f4e6f411-bc01-4cdd-ba76-eb951d43ad16
Peter, Richard
50b02410-1695-4b00-9611-ebb33ac88cac
Castell, Maria Victoria
7d2663d6-552c-47b8-ae98-5c1f5fdb9380
Otero, Ángel
1ba9c0dd-0a42-4436-b713-b0a50e961cc4
Pedersen, Nancy L.
22ca166b-d76d-401c-be51-a81c86bc1f4a
Deeg, Dorly JH
c6171d2b-7809-4bc9-9908-c10939a08958
Maggi, Stefania
57e7e62a-b7dd-4291-82e3-efc8c9a7e12a
EPOSA Research Group
Siviero, Paolo
8b9e9045-b666-4f5f-9d24-6ff3f00d70d8
Limongi, Federica
1e97a365-9c0d-42e9-9435-6c02a13003f0
Gesmundo, Antonella
7cacaafd-5c5b-4720-809a-1cba3bf9f1d2
Zambon, Sabina
d866a206-bf2e-4651-b50e-06bc450a64a0
Cooper, Cyrus
e05f5612-b493-4273-9b71-9e0ce32bdad6
Dennison, Elaine
ee647287-edb4-4392-8361-e59fd505b1d1
Edwards, Mark
06c1db44-4341-455e-8812-0ab4a1043828
van der Pas, Suzan
eeed262d-8106-4a78-8439-826b2d99bc78
Timmermans, Erik J.
0ebf8273-3f05-4925-bb79-f7db1b55dd29
van Schoor, Natasja M.
3a59a196-b132-414f-81de-2ad3b21f7a74
Schaap, Laura A.
b1b7ece4-8c4f-40af-b98a-9d21075fc6ce
Dallmeier, Dhayana
4c42ca12-bdda-4321-8158-8284af7f2bd1
Denkinger, Michael D.
f4e6f411-bc01-4cdd-ba76-eb951d43ad16
Peter, Richard
50b02410-1695-4b00-9611-ebb33ac88cac
Castell, Maria Victoria
7d2663d6-552c-47b8-ae98-5c1f5fdb9380
Otero, Ángel
1ba9c0dd-0a42-4436-b713-b0a50e961cc4
Pedersen, Nancy L.
22ca166b-d76d-401c-be51-a81c86bc1f4a
Deeg, Dorly JH
c6171d2b-7809-4bc9-9908-c10939a08958
Maggi, Stefania
57e7e62a-b7dd-4291-82e3-efc8c9a7e12a

Siviero, Paolo, Limongi, Federica, Gesmundo, Antonella, Zambon, Sabina, Cooper, Cyrus, Dennison, Elaine, Edwards, Mark, van der Pas, Suzan, Timmermans, Erik J., van Schoor, Natasja M., Schaap, Laura A., Dallmeier, Dhayana, Denkinger, Michael D., Peter, Richard, Castell, Maria Victoria, Otero, Ángel, Pedersen, Nancy L., Deeg, Dorly JH and Maggi, Stefania , EPOSA Research Group (2020) Factors associated with functional decline in hand and hip/knee osteoarthritis after a year’s time: data from the eposa study. Arthritis Care & Research. (doi:10.1002/acr.24404).

Record type: Article

Abstract

Objective: the study investigated factors that together with hand or hip/knee osteoarthritis (OA) could contribute to functional decline over a year’s time in elderly individuals.

Methods: the data of 1,886 individuals between the ages of 65‐85 in a prospective, observational population‐based study with 12‐18 month follow‐up in the context of the European Project on OSteoArthritis were analyzed. The outcome measures were self‐reported hand and hip/knee functional decline evaluated using a Minimal Clinically Important Difference of 4 on the AUStralian/CANadian hand OA Index and of 2 on the Western Ontario and McMaster Universities hip/knee OA physical function subscales, both normalized to 0‐100. Using regression models adjusted for sex, age, country, and education level, the baseline factors considered were: clinical hand or hip/knee OA, pain, analgesic/anti‐inflammatory medications, comorbidities, social isolation, income, walking time, grip strength, physical activity time, and medical/social care.

Results: after a year, 453 participants were identified as having “worse” hand functionality and 1,389 as “not worse”. Hand OA, anxiety, walking time and grip strength were risk factors for hand functional decline; pain was a confounder of the effect of hand OA.

Analgesic/anti‐inflammatory medications mediated the combined effect of hip/knee OA+pain on functional decline in the 554 individuals classified as having “worse” hip/knee functionality and the 1,291 “not worse” persons. Peripheral artery disease, obesity, and cognitive impairment were other baseline risk factors.

Conclusion: study findings showed that together with emotional status, chronic physical and cognitive conditions, OA affects hand and hip/knee functional decline.

Text
Siviero ARC - Accepted Manuscript
Download (11MB)

More information

Accepted/In Press date: 1 August 2020
e-pub ahead of print date: 8 August 2020

Identifiers

Local EPrints ID: 443306
URI: http://eprints.soton.ac.uk/id/eprint/443306
ISSN: 0893-7524
PURE UUID: d54d7af4-4309-4e0b-867d-7cae04b88a27
ORCID for Cyrus Cooper: ORCID iD orcid.org/0000-0003-3510-0709
ORCID for Elaine Dennison: ORCID iD orcid.org/0000-0002-3048-4961

Catalogue record

Date deposited: 20 Aug 2020 16:31
Last modified: 08 Aug 2021 04:01

Export record

Altmetrics

Contributors

Author: Paolo Siviero
Author: Federica Limongi
Author: Antonella Gesmundo
Author: Sabina Zambon
Author: Cyrus Cooper ORCID iD
Author: Elaine Dennison ORCID iD
Author: Mark Edwards
Author: Suzan van der Pas
Author: Erik J. Timmermans
Author: Natasja M. van Schoor
Author: Laura A. Schaap
Author: Dhayana Dallmeier
Author: Michael D. Denkinger
Author: Richard Peter
Author: Maria Victoria Castell
Author: Ángel Otero
Author: Nancy L. Pedersen
Author: Dorly JH Deeg
Author: Stefania Maggi
Corporate Author: EPOSA Research Group

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×