The University of Southampton
University of Southampton Institutional Repository

International consensus definition of low anterior resection syndrome

International consensus definition of low anterior resection syndrome
International consensus definition of low anterior resection syndrome

BACKGROUND: Low anterior resection syndrome is pragmatically defined as disordered bowel function after rectal resection leading to a detriment in quality of life. This broad characterization does not allow for precise estimates of prevalence. The low anterior resection syndrome score was designed as a simple tool for clinical evaluation of low anterior resection syndrome. Although the low anterior resection syndrome score has good clinical utility, it may not capture all important aspects that patients may experience.

OBJECTIVE: The aim of this collaboration was to develop an international consensus definition of low anterior resection syndrome that encompasses all aspects of the condition and is informed by all stakeholders.

DESIGN: This international patient-provider initiative used an online Delphi survey, regional patient consultation meetings, and an international consensus meeting.

PARTICIPANTS: Three expert groups participated: patients, surgeons, and other health professionals from 5 regions (Australasia, Denmark, Spain, Great Britain and Ireland, and North America) and in 3 languages (English, Spanish, and Danish).

MAIN OUTCOME MEASURE: The primary outcome measured was the priorities for the definition of low anterior resection syndrome.

RESULTS: Three hundred twenty-five participants (156 patients) registered. The response rates for successive rounds of the Delphi survey were 86%, 96%, and 99%. Eighteen priorities emerged from the Delphi survey. Patient consultation and consensus meetings refined these priorities to 8 symptoms and 8 consequences that capture essential aspects of the syndrome.

LIMITATIONS: Sampling bias may have been present, in particular, in the patient panel because social media was used extensively in recruitment. There was also dominance of the surgical panel at the final consensus meeting despite attempts to mitigate this.

CONCLUSIONS: This is the first definition of low anterior resection syndrome developed with direct input from a large international patient panel. The involvement of patients in all phases has ensured that the definition presented encompasses the vital aspects of the patient experience of low anterior resection syndrome. The novel separation of symptoms and consequences may enable greater sensitivity to detect changes in low anterior resection syndrome over time and with intervention.

Consensus definition, Low anterior resection syndrome, Patient reported, Rectal resection
0012-3706
274-284
Keane, Celia
6929845f-f722-4aaa-ac74-bc87db06133b
Fearnhead, Nicola S
39468f9f-bb98-4c77-ae75-315bdbad27f7
Bordeianou, Liliana G
8c5472a4-1372-48e7-bb78-9bfc702e9481
Christensen, Peter
742561eb-dc9b-475e-9faa-3e81a23a2dd6
Basany, Eloy Espin
07125c3b-e719-4c06-ad9a-cff74ab243ab
Laurberg, Søren
8ccc6192-751f-425e-97b3-8a6fe71f81f1
Mellgren, Anders
e35466d2-eff9-41e8-ad9b-e54f09d5eb47
Messick, Craig
29cd31de-2f19-459c-9ce4-abda51970512
Orangio, Guy R
c4c01c8d-fc19-412b-a378-13ae2abe1d53
Verjee, Azmina
a8f9ab8c-63e5-42cc-bc74-58c4bf8eb2e8
Wing, Kirsty
4c7aa7f8-1b9c-4b9b-a240-0898f3f2ce77
Bissett, Ian
58a20594-1d22-4899-b0f1-cc048b247d80
Nugent, Karen
79fcb89d-6ff2-47b8-ac2c-2afb24954456
LARS International Collaborative Group
Keane, Celia
6929845f-f722-4aaa-ac74-bc87db06133b
Fearnhead, Nicola S
39468f9f-bb98-4c77-ae75-315bdbad27f7
Bordeianou, Liliana G
8c5472a4-1372-48e7-bb78-9bfc702e9481
Christensen, Peter
742561eb-dc9b-475e-9faa-3e81a23a2dd6
Basany, Eloy Espin
07125c3b-e719-4c06-ad9a-cff74ab243ab
Laurberg, Søren
8ccc6192-751f-425e-97b3-8a6fe71f81f1
Mellgren, Anders
e35466d2-eff9-41e8-ad9b-e54f09d5eb47
Messick, Craig
29cd31de-2f19-459c-9ce4-abda51970512
Orangio, Guy R
c4c01c8d-fc19-412b-a378-13ae2abe1d53
Verjee, Azmina
a8f9ab8c-63e5-42cc-bc74-58c4bf8eb2e8
Wing, Kirsty
4c7aa7f8-1b9c-4b9b-a240-0898f3f2ce77
Bissett, Ian
58a20594-1d22-4899-b0f1-cc048b247d80
Nugent, Karen
79fcb89d-6ff2-47b8-ac2c-2afb24954456

Nugent, Karen , LARS International Collaborative Group (2020) International consensus definition of low anterior resection syndrome. Diseases of the Colon & Rectum, 63 (3), 274-284. (doi:10.1097/DCR.0000000000001583).

Record type: Article

Abstract

BACKGROUND: Low anterior resection syndrome is pragmatically defined as disordered bowel function after rectal resection leading to a detriment in quality of life. This broad characterization does not allow for precise estimates of prevalence. The low anterior resection syndrome score was designed as a simple tool for clinical evaluation of low anterior resection syndrome. Although the low anterior resection syndrome score has good clinical utility, it may not capture all important aspects that patients may experience.

OBJECTIVE: The aim of this collaboration was to develop an international consensus definition of low anterior resection syndrome that encompasses all aspects of the condition and is informed by all stakeholders.

DESIGN: This international patient-provider initiative used an online Delphi survey, regional patient consultation meetings, and an international consensus meeting.

PARTICIPANTS: Three expert groups participated: patients, surgeons, and other health professionals from 5 regions (Australasia, Denmark, Spain, Great Britain and Ireland, and North America) and in 3 languages (English, Spanish, and Danish).

MAIN OUTCOME MEASURE: The primary outcome measured was the priorities for the definition of low anterior resection syndrome.

RESULTS: Three hundred twenty-five participants (156 patients) registered. The response rates for successive rounds of the Delphi survey were 86%, 96%, and 99%. Eighteen priorities emerged from the Delphi survey. Patient consultation and consensus meetings refined these priorities to 8 symptoms and 8 consequences that capture essential aspects of the syndrome.

LIMITATIONS: Sampling bias may have been present, in particular, in the patient panel because social media was used extensively in recruitment. There was also dominance of the surgical panel at the final consensus meeting despite attempts to mitigate this.

CONCLUSIONS: This is the first definition of low anterior resection syndrome developed with direct input from a large international patient panel. The involvement of patients in all phases has ensured that the definition presented encompasses the vital aspects of the patient experience of low anterior resection syndrome. The novel separation of symptoms and consequences may enable greater sensitivity to detect changes in low anterior resection syndrome over time and with intervention.

Text
International_Consensus_Definition_of_Low_Anterior.4 - Version of Record
Download (684kB)

More information

Accepted/In Press date: 2020
Published date: March 2020
Additional Information: Publisher Copyright: Copyright © 2019 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Society of Colon and Rectal Surgeons. This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in anyway or used commercially without permission from the journal.
Keywords: Consensus definition, Low anterior resection syndrome, Patient reported, Rectal resection

Identifiers

Local EPrints ID: 443349
URI: http://eprints.soton.ac.uk/id/eprint/443349
ISSN: 0012-3706
PURE UUID: 253ada26-e084-483b-b6bc-d2f3383a2a4a

Catalogue record

Date deposited: 20 Aug 2020 16:38
Last modified: 16 Mar 2024 08:59

Export record

Altmetrics

Contributors

Author: Celia Keane
Author: Nicola S Fearnhead
Author: Liliana G Bordeianou
Author: Peter Christensen
Author: Eloy Espin Basany
Author: Søren Laurberg
Author: Anders Mellgren
Author: Craig Messick
Author: Guy R Orangio
Author: Azmina Verjee
Author: Kirsty Wing
Author: Ian Bissett
Author: Karen Nugent
Corporate Author: LARS International Collaborative Group

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×