Prognosis of children with acute lymphoblastic leukaemia (ALL) and intrachromosomal amplification of chromosome 21 (iAMP21)
Prognosis of children with acute lymphoblastic leukaemia (ALL) and intrachromosomal amplification of chromosome 21 (iAMP21)
Patients with acute lymphoblastic leukaemia (ALL) and an intrachromosomal amplification of chromosome 21 (iAMP21) comprise a novel and distinct biological subgroup. We prospectively screened 1,630 (84%) patients treated on the UK MRC ALL97 protocol for iAMP21 and herein present demographic, clinical and survival data on the 28 (2%) children found to harbour this abnormality. They had a common or pre-B ALL immunophenotype, were significantly older (median 9 versus 5 years) and had a lower white cell count (median 3.9 versus 12.4) compared to children without this abnormality. Notably, iAMP21 patients had a significantly inferior event free and overall survival at 5 years compared with other patients: 29% (95% CI 13%-48%) versus 78% (76%-80%) and 71% (51%-84%) versus 87% (85%-88%), respectively. As a result of this three-fold increase in relapse risk, newly diagnosed iAMP21 patients recruited to the current UK MRC ALL2003 trial are being treated on the high risk arm and are considered for bone marrow transplant in first remission.
2327-2330
Moorman, Anthony V.
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Richards, Susan M.
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Robinson, Hazel M.
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Strefford, Jon C.
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Gibson, Brenda E.S.
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Kinsey, Sally E.
ae9c91c4-cb85-4da4-a8e6-d01409ad4656
Eden, Tim O.B.
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Vora, Ajay J.
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Mitchell, Christopher D.
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Harrison, Christine J.
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On behalf of the UK Medical Research Council (MRC) / National Cancer Research Institute (NCRI) Childhood Leukaemia Working Party (CLWP)
2007
Moorman, Anthony V.
e4ced178-ee03-47ef-bc5e-25d8453951d5
Richards, Susan M.
dd70275e-ad17-43ef-98d9-1011161efcef
Robinson, Hazel M.
c406aa02-ca17-4ba1-9aa4-24bab6415fc0
Strefford, Jon C.
3782b392-f080-42bf-bdca-8aa5d6ca532f
Gibson, Brenda E.S.
873e5ffb-2fdb-4b81-9ace-640d5a8be2f0
Kinsey, Sally E.
ae9c91c4-cb85-4da4-a8e6-d01409ad4656
Eden, Tim O.B.
45ba5680-a475-4a7f-8dda-f442f7c178cb
Vora, Ajay J.
b57f0733-16ba-46c2-83bc-5529385dd47c
Mitchell, Christopher D.
02b0f415-8a1f-4643-954b-723075a74e24
Harrison, Christine J.
52da7673-509c-4b88-b92e-0c021c9c7d3e
Moorman, Anthony V., Richards, Susan M., Robinson, Hazel M., Strefford, Jon C., Gibson, Brenda E.S., Kinsey, Sally E., Eden, Tim O.B., Vora, Ajay J., Mitchell, Christopher D. and Harrison, Christine J.
,
On behalf of the UK Medical Research Council (MRC) / National Cancer Research Institute (NCRI) Childhood Leukaemia Working Party (CLWP)
(2007)
Prognosis of children with acute lymphoblastic leukaemia (ALL) and intrachromosomal amplification of chromosome 21 (iAMP21).
Blood, 109 (6), .
(doi:10.1182/blood-2006-08-040436).
Abstract
Patients with acute lymphoblastic leukaemia (ALL) and an intrachromosomal amplification of chromosome 21 (iAMP21) comprise a novel and distinct biological subgroup. We prospectively screened 1,630 (84%) patients treated on the UK MRC ALL97 protocol for iAMP21 and herein present demographic, clinical and survival data on the 28 (2%) children found to harbour this abnormality. They had a common or pre-B ALL immunophenotype, were significantly older (median 9 versus 5 years) and had a lower white cell count (median 3.9 versus 12.4) compared to children without this abnormality. Notably, iAMP21 patients had a significantly inferior event free and overall survival at 5 years compared with other patients: 29% (95% CI 13%-48%) versus 78% (76%-80%) and 71% (51%-84%) versus 87% (85%-88%), respectively. As a result of this three-fold increase in relapse risk, newly diagnosed iAMP21 patients recruited to the current UK MRC ALL2003 trial are being treated on the high risk arm and are considered for bone marrow transplant in first remission.
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Published date: 2007
Additional Information:
Blood First Edition Paper, prepublished online November 9, 2006
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Local EPrints ID: 44338
URI: http://eprints.soton.ac.uk/id/eprint/44338
ISSN: 0006-4971
PURE UUID: f28a97f4-5493-4bd3-862d-b145903252d6
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Date deposited: 27 Feb 2007
Last modified: 16 Mar 2024 03:40
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Contributors
Author:
Anthony V. Moorman
Author:
Susan M. Richards
Author:
Hazel M. Robinson
Author:
Brenda E.S. Gibson
Author:
Sally E. Kinsey
Author:
Tim O.B. Eden
Author:
Ajay J. Vora
Author:
Christopher D. Mitchell
Author:
Christine J. Harrison
Corporate Author: On behalf of the UK Medical Research Council (MRC) / National Cancer Research Institute (NCRI) Childhood Leukaemia Working Party (CLWP)
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