The role of the gut microbiome and diet in the pathogenesis of non-alcoholic fatty liver disease
The role of the gut microbiome and diet in the pathogenesis of non-alcoholic fatty liver disease
Non-alcoholic fatty liver disease (NAFLD) is the leading cause of chronic liver disease, with a prevalence that is increasing in parallel with the global rise in obesity and type 2 diabetes mellitus. The pathogenesis of NAFLD is complex and multifactorial, involving environmental, genetic and metabolic factors. The role of the diet and the gut microbiome is gaining interest as a significant factor in NAFLD pathogenesis. Dietary factors induce alterations in the composition of the gut microbiome (dysbiosis), commonly reflected by a reduction of the beneficial species and an increase in pathogenic microbiota. Due to the close relationship between the gut and liver, altering the gut microbiome can affect liver functions; promoting hepatic steatosis and inflammation. This review summarises the current evidence supporting an association between NAFLD and the gut microbiome and dietary factors. The review also explores potential underlying mechanisms underpinning these associations and whether manipulation of the gut microbiome is a potential therapeutic strategy to prevent or treat NAFLD.
Diet, Dysbiosis, Gastrointestinal microbiome, Non-alcoholic fatty liver disease
22-43
Jennison, Erica
fc1b0cad-c59a-4511-b6c8-62a1e84c5ee4
Byrne, Christopher
1370b997-cead-4229-83a7-53301ed2a43c
1 January 2021
Jennison, Erica
fc1b0cad-c59a-4511-b6c8-62a1e84c5ee4
Byrne, Christopher
1370b997-cead-4229-83a7-53301ed2a43c
Jennison, Erica and Byrne, Christopher
(2021)
The role of the gut microbiome and diet in the pathogenesis of non-alcoholic fatty liver disease.
Clinical and Molecular Hepatology, 27 (1), .
(doi:10.3350/cmh.2020.0129).
Abstract
Non-alcoholic fatty liver disease (NAFLD) is the leading cause of chronic liver disease, with a prevalence that is increasing in parallel with the global rise in obesity and type 2 diabetes mellitus. The pathogenesis of NAFLD is complex and multifactorial, involving environmental, genetic and metabolic factors. The role of the diet and the gut microbiome is gaining interest as a significant factor in NAFLD pathogenesis. Dietary factors induce alterations in the composition of the gut microbiome (dysbiosis), commonly reflected by a reduction of the beneficial species and an increase in pathogenic microbiota. Due to the close relationship between the gut and liver, altering the gut microbiome can affect liver functions; promoting hepatic steatosis and inflammation. This review summarises the current evidence supporting an association between NAFLD and the gut microbiome and dietary factors. The review also explores potential underlying mechanisms underpinning these associations and whether manipulation of the gut microbiome is a potential therapeutic strategy to prevent or treat NAFLD.
Text
NAFLD DIET GUT MICROBIOME
- Accepted Manuscript
More information
Accepted/In Press date: 12 August 2020
e-pub ahead of print date: 10 December 2020
Published date: 1 January 2021
Additional Information:
Funding Information:
CDB is Principal Investigator for the Investigation of synbiotic treatment in NAFLD (INSYTE) trial (www.clinicaltrials.gov registration number NCT01680640). CDB is supported in part by the Southampton National Institute for Health Research Biomedical Research Centre, UK.
Publisher Copyright:
© 2021 by Korean Association for the Study of the Liver.
Keywords:
Diet, Dysbiosis, Gastrointestinal microbiome, Non-alcoholic fatty liver disease
Identifiers
Local EPrints ID: 443405
URI: http://eprints.soton.ac.uk/id/eprint/443405
PURE UUID: da15332b-d9d6-4c8b-b00e-1b970da0e024
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Date deposited: 24 Aug 2020 16:34
Last modified: 17 Mar 2024 05:49
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Author:
Erica Jennison
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