The effects of xenon gas inhalation on neuropathology in a placental-induced brain injury model in neonates: A pilot study
The effects of xenon gas inhalation on neuropathology in a placental-induced brain injury model in neonates: A pilot study
Improved obstetric and neonatal care have reduced the prevalence of severe hypoxic-ischemic-encephalopathy (HIE), however 1-3/1000 newborns in the developed world(1) suffer death or neurodevelopmental disability from HIE. The normal development of the brain during gestation can also be altered by placental reprogramming under oxidative stress. Under these conditions, the placenta releases DNA damaging molecules, bone morphogenic proteins, microRNAs, and glutamate(2). At present, one is unable to diagnose or treat these factors.
Xenon, brain injury, cooling, hypoxic-ischaemic encephalopathy, neurodevelopment, placental reprogramming
119-122
Phillips, Thomas
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Menassa, David A
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Grant, Simon
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Cohen, Nicki
5868b493-b5ae-4092-a5de-7feb662fdffb
Thoresen, Marianne
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January 2021
Phillips, Thomas
ccaac4ca-e774-45ba-b6bf-bb5dac709286
Menassa, David A
eeb394a6-c72b-49d7-a820-95b0256c22d5
Grant, Simon
ff27dbb4-164d-492c-8958-beb1294d4a00
Cohen, Nicki
5868b493-b5ae-4092-a5de-7feb662fdffb
Thoresen, Marianne
57b47331-370d-49e9-9cd5-1055d50c8f39
Phillips, Thomas, Menassa, David A, Grant, Simon, Cohen, Nicki and Thoresen, Marianne
(2021)
The effects of xenon gas inhalation on neuropathology in a placental-induced brain injury model in neonates: A pilot study.
Acta Paediatrica, 110 (1), .
(doi:10.1111/apa.15486).
Abstract
Improved obstetric and neonatal care have reduced the prevalence of severe hypoxic-ischemic-encephalopathy (HIE), however 1-3/1000 newborns in the developed world(1) suffer death or neurodevelopmental disability from HIE. The normal development of the brain during gestation can also be altered by placental reprogramming under oxidative stress. Under these conditions, the placenta releases DNA damaging molecules, bone morphogenic proteins, microRNAs, and glutamate(2). At present, one is unable to diagnose or treat these factors.
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More information
Accepted/In Press date: 14 July 2020
e-pub ahead of print date: 18 July 2020
Published date: January 2021
Additional Information:
Funding Information:
We acknowledge the financial support of the JP Moulton foundation, the Perivoli Trust and SPARKS-The Children's Medical Research Charity. We also acknowledge Dr Charles Patrick Case for his input in this study and Dr John Dingley for providing Xenon-delivery expertise.
Keywords:
Xenon, brain injury, cooling, hypoxic-ischaemic encephalopathy, neurodevelopment, placental reprogramming
Identifiers
Local EPrints ID: 443435
URI: http://eprints.soton.ac.uk/id/eprint/443435
ISSN: 0803-5253
PURE UUID: 111ea211-28e5-4758-a49e-07582e991fb0
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Date deposited: 25 Aug 2020 16:31
Last modified: 16 Mar 2024 08:52
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Contributors
Author:
Thomas Phillips
Author:
David A Menassa
Author:
Simon Grant
Author:
Nicki Cohen
Author:
Marianne Thoresen
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