A blueprint for translational regenerative medicine
A blueprint for translational regenerative medicine
The past few decades have produced a large number of proof-of-concept studies in regenerative medicine. However, the route to clinical adoption is fraught with technical and translational obstacles that frequently consign promising academic solutions to the so-called “valley of death.” Here, we present a proposed blueprint for translational regenerative medicine. We offer principles to help guide the selection of cells and materials, present key in vivo imaging modalities, and argue that the host immune response should be considered throughout design and development. Last, we suggest a pathway to navigate the often complex regulatory and manufacturing landscape of translational regenerative medicine.
Oreffo, Richard
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Armstrong, James
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Keane, Timothy
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Roques, A.
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Patrick, P.
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Mooney, Claire
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Kuan, Wei-Li
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Pisupati, Venkat
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Stuckey, D
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Watt, Fiona M.
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Forbes, Stuart
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Barker, Roger
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Stevens, Molly
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2 December 2020
Oreffo, Richard
ff9fff72-6855-4d0f-bfb2-311d0e8f3778
Armstrong, James
f6418461-c95c-4d2e-928c-e0bd534c100a
Keane, Timothy
a749fca1-c149-4eba-a7d4-4fe1a0bba414
Roques, A.
311a1a36-4a32-4d0a-b46e-a8cbf7c65b92
Patrick, P.
fab9edab-ac20-43e9-bc4a-ab46533d529b
Mooney, Claire
bdf56934-2125-4f4a-bbe9-42eb5e284cfb
Kuan, Wei-Li
f32d8025-2376-4408-a285-3f3d9fc11bdc
Pisupati, Venkat
536b825c-0e3d-45a5-8d00-2c26cb2c2935
Stuckey, D
11206e39-4fb1-456d-8613-f73dacc7fafb
Watt, Fiona M.
24fff937-94b0-4127-8cbb-e8bd6e01fa29
Forbes, Stuart
87891041-4ab1-4c68-a389-42ead87a7a22
Barker, Roger
46d636f3-43ce-4591-970f-b897422965d9
Stevens, Molly
2af17549-764e-4c18-a316-f7dc790398e0
Oreffo, Richard, Armstrong, James, Keane, Timothy, Roques, A., Patrick, P., Mooney, Claire, Kuan, Wei-Li, Pisupati, Venkat, Stuckey, D, Watt, Fiona M., Forbes, Stuart, Barker, Roger and Stevens, Molly
(2020)
A blueprint for translational regenerative medicine.
Science Translational Medicine, 12 (572), [eaaz2253].
(doi:10.1126/scitranslmed.aaz2253).
Abstract
The past few decades have produced a large number of proof-of-concept studies in regenerative medicine. However, the route to clinical adoption is fraught with technical and translational obstacles that frequently consign promising academic solutions to the so-called “valley of death.” Here, we present a proposed blueprint for translational regenerative medicine. We offer principles to help guide the selection of cells and materials, present key in vivo imaging modalities, and argue that the host immune response should be considered throughout design and development. Last, we suggest a pathway to navigate the often complex regulatory and manufacturing landscape of translational regenerative medicine.
Text
A Blueprint for Translational Regenerative Medicine_Revised_Accepted_WithFigures
- Accepted Manuscript
More information
Accepted/In Press date: 5 March 2020
e-pub ahead of print date: 2 December 2020
Published date: 2 December 2020
Additional Information:
Publisher Copyright:
Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works
Identifiers
Local EPrints ID: 443568
URI: http://eprints.soton.ac.uk/id/eprint/443568
ISSN: 1946-6234
PURE UUID: 24db1bde-e3c8-4eea-95c5-cbb2ff493c18
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Date deposited: 02 Sep 2020 16:30
Last modified: 06 Jun 2024 04:18
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Contributors
Author:
James Armstrong
Author:
Timothy Keane
Author:
A. Roques
Author:
P. Patrick
Author:
Claire Mooney
Author:
Wei-Li Kuan
Author:
Venkat Pisupati
Author:
D Stuckey
Author:
Fiona M. Watt
Author:
Stuart Forbes
Author:
Roger Barker
Author:
Molly Stevens
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