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A blueprint for translational regenerative medicine

A blueprint for translational regenerative medicine
A blueprint for translational regenerative medicine

The past few decades have produced a large number of proof-of-concept studies in regenerative medicine. However, the route to clinical adoption is fraught with technical and translational obstacles that frequently consign promising academic solutions to the so-called “valley of death.” Here, we present a proposed blueprint for translational regenerative medicine. We offer principles to help guide the selection of cells and materials, present key in vivo imaging modalities, and argue that the host immune response should be considered throughout design and development. Last, we suggest a pathway to navigate the often complex regulatory and manufacturing landscape of translational regenerative medicine.

1946-6234
Oreffo, Richard
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Armstrong, James
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Keane, Timothy
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Roques, A.
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Patrick, P.
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Mooney, Claire
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Kuan, Wei-Li
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Pisupati, Venkat
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Stuckey, D
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Watt, Fiona M.
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Forbes, Stuart
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Barker, Roger
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Stevens, Molly
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Oreffo, Richard
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Armstrong, James
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Keane, Timothy
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Roques, A.
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Patrick, P.
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Mooney, Claire
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Kuan, Wei-Li
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Pisupati, Venkat
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Stuckey, D
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Watt, Fiona M.
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Forbes, Stuart
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Barker, Roger
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Stevens, Molly
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Oreffo, Richard, Armstrong, James, Keane, Timothy, Roques, A., Patrick, P., Mooney, Claire, Kuan, Wei-Li, Pisupati, Venkat, Stuckey, D, Watt, Fiona M., Forbes, Stuart, Barker, Roger and Stevens, Molly (2020) A blueprint for translational regenerative medicine. Science Translational Medicine, 12 (572), [eaaz2253]. (doi:10.1126/scitranslmed.aaz2253).

Record type: Review

Abstract

The past few decades have produced a large number of proof-of-concept studies in regenerative medicine. However, the route to clinical adoption is fraught with technical and translational obstacles that frequently consign promising academic solutions to the so-called “valley of death.” Here, we present a proposed blueprint for translational regenerative medicine. We offer principles to help guide the selection of cells and materials, present key in vivo imaging modalities, and argue that the host immune response should be considered throughout design and development. Last, we suggest a pathway to navigate the often complex regulatory and manufacturing landscape of translational regenerative medicine.

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A Blueprint for Translational Regenerative Medicine_Revised_Accepted_WithFigures - Accepted Manuscript
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More information

Accepted/In Press date: 5 March 2020
e-pub ahead of print date: 2 December 2020
Published date: 2 December 2020
Additional Information: Publisher Copyright: Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works

Identifiers

Local EPrints ID: 443568
URI: http://eprints.soton.ac.uk/id/eprint/443568
ISSN: 1946-6234
PURE UUID: 24db1bde-e3c8-4eea-95c5-cbb2ff493c18
ORCID for Richard Oreffo: ORCID iD orcid.org/0000-0001-5995-6726

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Date deposited: 02 Sep 2020 16:30
Last modified: 06 Jun 2024 04:18

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Contributors

Author: Richard Oreffo ORCID iD
Author: James Armstrong
Author: Timothy Keane
Author: A. Roques
Author: P. Patrick
Author: Claire Mooney
Author: Wei-Li Kuan
Author: Venkat Pisupati
Author: D Stuckey
Author: Fiona M. Watt
Author: Stuart Forbes
Author: Roger Barker
Author: Molly Stevens

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