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A blueprint for translational regenerative medicine

A blueprint for translational regenerative medicine
A blueprint for translational regenerative medicine
The last few decades have produced a large number of proof-of-concept studies in regenerative medicine. However, the route to clinical adoptionis fraught with technical and translational obstacles that frequentlyconsign promising academic solutions to the so-called “valley of death.” This review is intended to serve as a blueprint for translational regenerative medicine: we suggest principles to help guide cell and material selection, present key in vivoimaging modalitiesand argue that the host immune response should be considered throughout therapeutic development. Finally, we suggest a pathway to navigate the often complex regulatory and manufacturing landscape of translational regenerative medicine
1946-6234
Oreffo, Richard
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Armstrong, James
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Keane, Timothy
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Roques, A.
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Patrick, P.
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Mooney, Claire
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Kuan, Wei-Li
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Pisupati, Venkat
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Stuckey, D
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Watt, Fiona M.
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Forbes, Stuart
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Barker, Roger
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Stevens, Molly
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Oreffo, Richard
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Armstrong, James
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Keane, Timothy
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Roques, A.
311a1a36-4a32-4d0a-b46e-a8cbf7c65b92
Patrick, P.
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Mooney, Claire
bdf56934-2125-4f4a-bbe9-42eb5e284cfb
Kuan, Wei-Li
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Pisupati, Venkat
536b825c-0e3d-45a5-8d00-2c26cb2c2935
Stuckey, D
11206e39-4fb1-456d-8613-f73dacc7fafb
Watt, Fiona M.
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Forbes, Stuart
87891041-4ab1-4c68-a389-42ead87a7a22
Barker, Roger
46d636f3-43ce-4591-970f-b897422965d9
Stevens, Molly
2af17549-764e-4c18-a316-f7dc790398e0

Oreffo, Richard, Armstrong, James, Keane, Timothy, Roques, A., Patrick, P., Mooney, Claire, Kuan, Wei-Li, Pisupati, Venkat, Stuckey, D, Watt, Fiona M., Forbes, Stuart, Barker, Roger and Stevens, Molly (2020) A blueprint for translational regenerative medicine. Science Translational Medicine, 12 (572). (doi:10.1126/scitranslmed.aaz2253).

Record type: Article

Abstract

The last few decades have produced a large number of proof-of-concept studies in regenerative medicine. However, the route to clinical adoptionis fraught with technical and translational obstacles that frequentlyconsign promising academic solutions to the so-called “valley of death.” This review is intended to serve as a blueprint for translational regenerative medicine: we suggest principles to help guide cell and material selection, present key in vivoimaging modalitiesand argue that the host immune response should be considered throughout therapeutic development. Finally, we suggest a pathway to navigate the often complex regulatory and manufacturing landscape of translational regenerative medicine

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A Blueprint for Translational Regenerative Medicine_Revised_Accepted_WithFigures - Accepted Manuscript
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Accepted/In Press date: 5 March 2020
e-pub ahead of print date: 2 December 2020

Identifiers

Local EPrints ID: 443568
URI: http://eprints.soton.ac.uk/id/eprint/443568
ISSN: 1946-6234
PURE UUID: 24db1bde-e3c8-4eea-95c5-cbb2ff493c18
ORCID for Richard Oreffo: ORCID iD orcid.org/0000-0001-5995-6726

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Date deposited: 02 Sep 2020 16:30
Last modified: 18 Feb 2021 16:54

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