Acute high-altitude pathologies and their treatment
Acute high-altitude pathologies and their treatment
Ascent to high altitude triggers a wide range of physiological changes. However, ascent is also associated with three acute pathologies: acute mountain sickness, high-altitude cerebral oedema (HACE) and high-altitude pulmonary oedema (HAPE). Awareness and understanding of these conditions allows measures to be taken to reduce the risk of them developing through careful planning and, where appropriate, pharmacological prophylaxis. Both HACE and HAPE are life threatening, necessitating prompt diagnosis and management. Acute mountain sickness, although usually benign, may progress, to HACE or HAPE, if not managed appropriately. This review examines each pathology providing options for risk reduction, diagnosis and management, as well as considering comorbidity at altitude, drawing upon recent advances and consensus guidelines in the field.
Altitude, AMS, HACE, HAPE, Hypoxia, Hypoxic
42-48
Jackson, Alexander I.R.
9bbcdd0e-a9c8-46d3-945c-53e9262c4f4c
Cumpstey, Andrew F.
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Grocott, Michael P.W.
1e87b741-513e-4a22-be13-0f7bb344e8c2
1 April 2020
Jackson, Alexander I.R.
9bbcdd0e-a9c8-46d3-945c-53e9262c4f4c
Cumpstey, Andrew F.
cd040417-5e62-41d2-8640-1ec8905858a7
Grocott, Michael P.W.
1e87b741-513e-4a22-be13-0f7bb344e8c2
Jackson, Alexander I.R., Cumpstey, Andrew F. and Grocott, Michael P.W.
(2020)
Acute high-altitude pathologies and their treatment.
Current Opinion in Endocrine and Metabolic Research, 11, .
(doi:10.1016/j.coemr.2019.12.001).
Abstract
Ascent to high altitude triggers a wide range of physiological changes. However, ascent is also associated with three acute pathologies: acute mountain sickness, high-altitude cerebral oedema (HACE) and high-altitude pulmonary oedema (HAPE). Awareness and understanding of these conditions allows measures to be taken to reduce the risk of them developing through careful planning and, where appropriate, pharmacological prophylaxis. Both HACE and HAPE are life threatening, necessitating prompt diagnosis and management. Acute mountain sickness, although usually benign, may progress, to HACE or HAPE, if not managed appropriately. This review examines each pathology providing options for risk reduction, diagnosis and management, as well as considering comorbidity at altitude, drawing upon recent advances and consensus guidelines in the field.
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e-pub ahead of print date: 20 December 2019
Published date: 1 April 2020
Keywords:
Altitude, AMS, HACE, HAPE, Hypoxia, Hypoxic
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Local EPrints ID: 443614
URI: http://eprints.soton.ac.uk/id/eprint/443614
PURE UUID: f057414e-ab7e-4a83-9353-5014120d9d25
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Date deposited: 04 Sep 2020 16:32
Last modified: 20 Apr 2024 02:41
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Author:
Alexander I.R. Jackson
Author:
Andrew F. Cumpstey
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