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A one-pot domino reaction in constructing isoorotate bases and their nucleosides

A one-pot domino reaction in constructing isoorotate bases and their nucleosides
A one-pot domino reaction in constructing isoorotate bases and their nucleosides
A novel strategy, involving the coupling of enaminoesters with chlorosulfonyl isocyanate and accelerated by microwave irradiation, enables the straightforward preparation of the biologically important isoorotate bases. Extensions to nucleoside derivatives are also described.
enamines, isocyanates, isoorotates, microwaves, nucleosides
0040-4039
1989-1992
Avalos, Martin
75b746b8-64d3-4451-be7a-c7c536ed6602
Babiano, Reyes
b7ffd91c-bacd-4372-ab99-fc30ac2450ae
Cintas, Pedro
29979233-8382-47a8-bde7-1faf4869308c
Hursthouse, Michael B.
57a2ddf9-b1b3-4f38-bfe9-ef2f526388da
Jiménez, José
f11916d4-1cc7-461a-bcb0-437c63cb6544
Lerma, Encarnación
36b092b7-1dc3-48fd-a9d1-dc25ad232e9d
Light, Mark E.
cf57314e-6856-491b-a8d2-2dffc452e161
Palacios, Juan C.
2c06e379-89b3-46b1-95c8-7f5057732f9f
Avalos, Martin
75b746b8-64d3-4451-be7a-c7c536ed6602
Babiano, Reyes
b7ffd91c-bacd-4372-ab99-fc30ac2450ae
Cintas, Pedro
29979233-8382-47a8-bde7-1faf4869308c
Hursthouse, Michael B.
57a2ddf9-b1b3-4f38-bfe9-ef2f526388da
Jiménez, José
f11916d4-1cc7-461a-bcb0-437c63cb6544
Lerma, Encarnación
36b092b7-1dc3-48fd-a9d1-dc25ad232e9d
Light, Mark E.
cf57314e-6856-491b-a8d2-2dffc452e161
Palacios, Juan C.
2c06e379-89b3-46b1-95c8-7f5057732f9f

Avalos, Martin, Babiano, Reyes, Cintas, Pedro, Hursthouse, Michael B., Jiménez, José, Lerma, Encarnación, Light, Mark E. and Palacios, Juan C. (2006) A one-pot domino reaction in constructing isoorotate bases and their nucleosides. Tetrahedron Letters, 47 (12), 1989-1992. (doi:10.1016/j.tetlet.2006.01.057).

Record type: Article

Abstract

A novel strategy, involving the coupling of enaminoesters with chlorosulfonyl isocyanate and accelerated by microwave irradiation, enables the straightforward preparation of the biologically important isoorotate bases. Extensions to nucleoside derivatives are also described.

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More information

Published date: 2006
Keywords: enamines, isocyanates, isoorotates, microwaves, nucleosides

Identifiers

Local EPrints ID: 44366
URI: https://eprints.soton.ac.uk/id/eprint/44366
ISSN: 0040-4039
PURE UUID: 0b5cd666-db7d-4bd0-acad-6f6b31ee91b0
ORCID for Mark E. Light: ORCID iD orcid.org/0000-0002-0585-0843

Catalogue record

Date deposited: 28 Feb 2007
Last modified: 14 Mar 2019 01:48

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Contributors

Author: Martin Avalos
Author: Reyes Babiano
Author: Pedro Cintas
Author: José Jiménez
Author: Encarnación Lerma
Author: Mark E. Light ORCID iD
Author: Juan C. Palacios

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