Early-life inflammatory events: a risk factor for hearing loss in later life
Early-life inflammatory events: a risk factor for hearing loss in later life
Age-related hearing loss is a progressive, degenerative condition that affects 50% of individuals over 70. Hearing loss is one of the greatest risk factors for dementia. Lifestyle including smoking, diet and medical history are all associated with susceptibility to loss of hearing with age. We hypothesise that the association between early-life inflammatory events and hearing loss is due to priming of innate immune cells in the auditory system.
Otitis media is a chronic early-life inflammatory condition of the middle ear that is associated with recurrent infection. Using a mouse model for otitis media, we are investigating how immune cells in the auditory pathway respond in otitis media and how this is altered when overlaid with an infection (Non-typeable Haemophilus influenzae - NTHi).
Immunohistochemical staining identified that otitis media caused increased microglial activation in the auditory system. When overlaid with infection, this response was exacerbated as evidenced by increased Il-1 production and greater susceptibility to infection with NTHi.
These results identify that pre-existing middle ear inflammation alters the phenotype of innate immune cells in the auditory system resulting in a heightened inflammatory response to an additional insult. This could lead to greater damage in the auditory pathway and subsequent hearing loss.
Hough, Katie
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Sanderson, Alan
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Watson, Evie
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Hood, Derek W.
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Verschuur, Carl
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Newman, Tracey
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19 September 2019
Hough, Katie
81d8630c-6e02-4bea-858a-377717476f6e
Sanderson, Alan
ea92395a-998b-4bbb-ba91-24b2b1d4f6aa
Watson, Evie
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Hood, Derek W.
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Verschuur, Carl
5e15ee1c-3a44-4dbe-ad43-ec3b50111e41
Newman, Tracey
322290cb-2e9c-445d-a047-00b1bea39a25
Hough, Katie, Sanderson, Alan, Watson, Evie, Hood, Derek W., Verschuur, Carl and Newman, Tracey
(2019)
Early-life inflammatory events: a risk factor for hearing loss in later life.
17th Southampton Neurosciences conference: The Neuroscience of Lifelong Illness.
Record type:
Conference or Workshop Item
(Poster)
Abstract
Age-related hearing loss is a progressive, degenerative condition that affects 50% of individuals over 70. Hearing loss is one of the greatest risk factors for dementia. Lifestyle including smoking, diet and medical history are all associated with susceptibility to loss of hearing with age. We hypothesise that the association between early-life inflammatory events and hearing loss is due to priming of innate immune cells in the auditory system.
Otitis media is a chronic early-life inflammatory condition of the middle ear that is associated with recurrent infection. Using a mouse model for otitis media, we are investigating how immune cells in the auditory pathway respond in otitis media and how this is altered when overlaid with an infection (Non-typeable Haemophilus influenzae - NTHi).
Immunohistochemical staining identified that otitis media caused increased microglial activation in the auditory system. When overlaid with infection, this response was exacerbated as evidenced by increased Il-1 production and greater susceptibility to infection with NTHi.
These results identify that pre-existing middle ear inflammation alters the phenotype of innate immune cells in the auditory system resulting in a heightened inflammatory response to an additional insult. This could lead to greater damage in the auditory pathway and subsequent hearing loss.
Text
Kate Hough - SONG Poster 2019
More information
Published date: 19 September 2019
Venue - Dates:
17th Southampton Neurosciences conference: The Neuroscience of Lifelong Illness, 2019-09-19
Identifiers
Local EPrints ID: 443713
URI: http://eprints.soton.ac.uk/id/eprint/443713
PURE UUID: e3e03bf1-5a70-44bd-9862-32c0984fa14d
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Date deposited: 09 Sep 2020 16:34
Last modified: 10 Apr 2024 02:08
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Contributors
Author:
Katie Hough
Author:
Alan Sanderson
Author:
Evie Watson
Author:
Derek W. Hood
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