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Maternal lutein and zeaxanthin concentrations in relation to offspring visual acuity at 3 years of age: the GUSTO study

Maternal lutein and zeaxanthin concentrations in relation to offspring visual acuity at 3 years of age: the GUSTO study
Maternal lutein and zeaxanthin concentrations in relation to offspring visual acuity at 3 years of age: the GUSTO study
Lutein and zeaxanthin play important roles in visual functions, but their influence on early visual development is unclear. We related maternal lutein and zeaxanthin concentrations during pregnancy to offspring visual acuity (VA) in 471 mother–child pairs from the Growing Up in Singapore Towards healthy Outcomes (GUSTO) cohort. Maternal concentrations of plasma lutein and zeaxanthin were determined at delivery. We measured uncorrected distance of VA in 3-year old children using a LEA Symbols chart; readings were converted to the logarithm of Minimum Angle of Resolution (logMAR), with >0.3 logMAR indicating poor VA. Associations were examined using linear or Poisson regression adjusted for confounders. The median (inter-quartile range) of maternal lutein and zeaxanthin concentrations were 0.13 (0.09, 0.18) and 0.09 (0.07, 0.12) µmol/L, respectively. A total of 126 children had poor VA. The highest tertile of maternal zeaxanthin concentration was associated with 38% lower likelihood of poor VA in children (95% CI: 0.42, 0.93, p-Trends = 0.02). Higher maternal lutein concentrations were associated with a lower likelihood of poor VA in children (RR 0.60 (95% CI: 0.40, 0.88) for middle tertile; RR 0.78 (95% CI: 0.51, 1.19) for highest tertile (p-Quadratic = 0.02)). In conclusion, lutein and zeaxanthin status during pregnancy may influence offspring early visual development; but the results require confirmation with further studies, including more comprehensive measurements of macular functions.
Child, Lutein, Pregnancy, Visual acuity, Zeaxanthin
2072-6643
Lai, Jun S.
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Veetil, Vaishnavi O.
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Lanca, Carla
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Lee, Bee Lan
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Godfrey, Keith
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Gluckman, Peter D.
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Shek, Lynette P.
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Yap, Fabian
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Tan, Kok Hian
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Chong, Yap-Seng
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Ong, Choon Nam
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Ngo, Cheryl S.
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Saw, Seang-Mei
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Chong, Mary Foong-Fong
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Lai, Jun S.
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Veetil, Vaishnavi O.
6ca3675e-b554-4e98-8338-89d5f9e27207
Lanca, Carla
8b3174ad-f727-4ec2-a0a1-0408d1e089a9
Lee, Bee Lan
70d26f4c-f44d-4ac4-b13a-61cd1cdfc911
Godfrey, Keith
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Gluckman, Peter D.
e916630e-5ae2-437c-a1d1-8e24c0e05589
Shek, Lynette P.
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Yap, Fabian
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Tan, Kok Hian
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Chong, Yap-Seng
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Ong, Choon Nam
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Ngo, Cheryl S.
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Saw, Seang-Mei
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Chong, Mary Foong-Fong
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Lai, Jun S., Veetil, Vaishnavi O., Lanca, Carla, Lee, Bee Lan, Godfrey, Keith, Gluckman, Peter D., Shek, Lynette P., Yap, Fabian, Tan, Kok Hian, Chong, Yap-Seng, Ong, Choon Nam, Ngo, Cheryl S., Saw, Seang-Mei and Chong, Mary Foong-Fong (2020) Maternal lutein and zeaxanthin concentrations in relation to offspring visual acuity at 3 years of age: the GUSTO study. Nutrients, 12 (2), [274]. (doi:10.3390/nu12020274).

Record type: Article

Abstract

Lutein and zeaxanthin play important roles in visual functions, but their influence on early visual development is unclear. We related maternal lutein and zeaxanthin concentrations during pregnancy to offspring visual acuity (VA) in 471 mother–child pairs from the Growing Up in Singapore Towards healthy Outcomes (GUSTO) cohort. Maternal concentrations of plasma lutein and zeaxanthin were determined at delivery. We measured uncorrected distance of VA in 3-year old children using a LEA Symbols chart; readings were converted to the logarithm of Minimum Angle of Resolution (logMAR), with >0.3 logMAR indicating poor VA. Associations were examined using linear or Poisson regression adjusted for confounders. The median (inter-quartile range) of maternal lutein and zeaxanthin concentrations were 0.13 (0.09, 0.18) and 0.09 (0.07, 0.12) µmol/L, respectively. A total of 126 children had poor VA. The highest tertile of maternal zeaxanthin concentration was associated with 38% lower likelihood of poor VA in children (95% CI: 0.42, 0.93, p-Trends = 0.02). Higher maternal lutein concentrations were associated with a lower likelihood of poor VA in children (RR 0.60 (95% CI: 0.40, 0.88) for middle tertile; RR 0.78 (95% CI: 0.51, 1.19) for highest tertile (p-Quadratic = 0.02)). In conclusion, lutein and zeaxanthin status during pregnancy may influence offspring early visual development; but the results require confirmation with further studies, including more comprehensive measurements of macular functions.

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More information

Accepted/In Press date: 20 January 2020
e-pub ahead of print date: 21 January 2020
Keywords: Child, Lutein, Pregnancy, Visual acuity, Zeaxanthin

Identifiers

Local EPrints ID: 443751
URI: http://eprints.soton.ac.uk/id/eprint/443751
ISSN: 2072-6643
PURE UUID: c7e56c5b-a7aa-42a5-8898-87e4dfa775d0
ORCID for Keith Godfrey: ORCID iD orcid.org/0000-0002-4643-0618

Catalogue record

Date deposited: 10 Sep 2020 16:57
Last modified: 22 Nov 2021 02:36

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Contributors

Author: Jun S. Lai
Author: Vaishnavi O. Veetil
Author: Carla Lanca
Author: Bee Lan Lee
Author: Keith Godfrey ORCID iD
Author: Peter D. Gluckman
Author: Lynette P. Shek
Author: Fabian Yap
Author: Kok Hian Tan
Author: Yap-Seng Chong
Author: Choon Nam Ong
Author: Cheryl S. Ngo
Author: Seang-Mei Saw
Author: Mary Foong-Fong Chong

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