The University of Southampton
University of Southampton Institutional Repository
Warning ePrints Soton is experiencing an issue with some file downloads not being available. We are working hard to fix this. Please bear with us.

Active Brains - a digital intervention to reduce cognitive decline in older adults: protocol for a feasibility randomised control trial

Active Brains - a digital intervention to reduce cognitive decline in older adults: protocol for a feasibility randomised control trial
Active Brains - a digital intervention to reduce cognitive decline in older adults: protocol for a feasibility randomised control trial
Background
Increasing physical activity, improving diet and doing 'brain training' exercises are associated with reduced cognitive decline in older adults. Here we describe a feasibility trial of the Active Brains intervention, an online digital intervention developed to support older adults to make these three healthy behaviour changes associated with cognitive health.

Objective
The Active Brains trial is a randomised feasibility trial that will test how accessible, acceptable and feasible the Active Brains intervention is and the effectiveness of the study procedures that we plan to use in our larger main trial.
Methods
The randomised controlled trial uses a parallel design. We will be trialling the intervention with two populations recruited through GP practices in England 2018-19: 1) older adults with signs of cognitive decline, 2) older adults without any cognitive decline. Trial participants will be randomly allocated to one of three study groups: 1) usual care or 2) the Active Brains intervention, or 3) the Active Brains website plus brief support from a trained coach (over the phone or by email). The main outcomes are performance on cognitive tasks, Quality of Life (using EQ-5D-5L), Instrumental Activities of Daily Living and diagnoses of dementia. Secondary outcomes (including depression, enablement and healthcare costs) and process measures (including qualitative interviews with participants and supporters) will also be collected.

Results
Results will be published in peer-reviewed journals, presented at conferences and shared at public engagement events. Data collection was completed in May 2020, and results will be reported in 2021.

Conclusions
The findings of this study will help us to identify and make important changes to the website, the support received or the study procedures before we progress to our main randomized phase III trial.

Ethics and dissemination
The trial has been approved by the NHS Research Ethics Committee (Reference 17/SC/0463). The results of this trial will be published in peer-reviewed journals and through conference presentations.

Trial registration number: ISRCTN 23758980
aging, behaviour change, cognitive health, digital intervention, e-health, feasibility, randomised trial
Smith, Kirsten
9da65772-0efa-4267-87ff-563f9757b34e
Bradbury, Katherine
87fce0b9-d9c5-42b4-b041-bffeb4430863
Essery, Rosie
6bf53e81-577f-4a95-ba45-11aa64d1ee53
Pollet, Sebastien
a3b6c348-04f6-48b0-a729-f047484c5e6e
Mowbray, Fiona
0a9e37a7-06c7-4926-95cb-af2d1eb22157
Slodkowska-Barabasz, Joanna
18182048-55ee-474c-9790-1f5b81fa585c
Denison-Day, James
49c0d012-eadc-44eb-b06c-da7714be145a
Hayter, Victoria
eb2d271d-e17b-4ef6-b761-a52f6342293a
Kelly, Joanne Marie
b7094829-aeb1-4bc1-b64c-7b7c716f73b5
Somerville, Jane
b7f3973b-e643-413c-9b6a-a2f1ccd9937a
Zhang, Jin
27009b1e-dd46-4a6c-a3bc-d5a90246d9e9
Grey, Elisabeth B
29e3f997-95c1-45c1-959c-be1b94172059
Western, Max
7f55bcc2-c832-4e7c-97fb-22e21ad5ddfa
Ferrey, Anne
38b7fff0-a408-47f5-93ad-069d2678c8d1
Krusche, Adele
336ef9cd-ec58-4826-8eaa-9c9f6edbb0ee
Stuart, Beth
626862fc-892b-4f6d-9cbb-7a8d7172b209
Mutrie, Nanette
9c1f3f0a-434e-4275-a546-63d25201a86e
Robinson, Sian
6ada395c-a5e4-484b-b3a8-6760db7a48e4
Guiqing, Lily
89041c4d-4198-4723-b098-0f82a8b917fb
Griffiths, Gareth
7fd300c0-d279-4ff6-842d-aa1f2b9b864d
Robinson, Louise
488aea33-4475-4b1f-83f8-018bfcb56a1f
Rossor, Martin N.
dbde2557-152c-42ca-8a54-b50d0f18ef5e
Gallacher, John E.
e05d736b-eb13-4f6b-b8ca-6f417d60a6a7
Griffin, Simon J.
1f8d5095-3c10-4973-a2c4-84ce6415d118
Kendrick, Tony
c697a72c-c698-469d-8ac2-f00df40583e5
Rathod, Shanaya
b4dddbe5-e4aa-4069-bd03-20cd6332639c
Gudgin, Bernard
e832fb17-bfdd-42ab-a9dc-7312629c743e
Phillips, Rosemary
19c8044a-0290-4861-9416-df93fadd473d
Stokes, Tom
4c63a939-5880-467a-8068-55a524e3eaf0
Niven, John
c61ef2b8-226e-4ab3-918e-484d02a3826d
Little, Paul
1bf2d1f7-200c-47a5-ab16-fe5a8756a777
Yardley, Lucy
64be42c4-511d-484d-abaa-f8813452a22e
Smith, Kirsten
9da65772-0efa-4267-87ff-563f9757b34e
Bradbury, Katherine
87fce0b9-d9c5-42b4-b041-bffeb4430863
Essery, Rosie
6bf53e81-577f-4a95-ba45-11aa64d1ee53
Pollet, Sebastien
a3b6c348-04f6-48b0-a729-f047484c5e6e
Mowbray, Fiona
0a9e37a7-06c7-4926-95cb-af2d1eb22157
Slodkowska-Barabasz, Joanna
18182048-55ee-474c-9790-1f5b81fa585c
Denison-Day, James
49c0d012-eadc-44eb-b06c-da7714be145a
Hayter, Victoria
eb2d271d-e17b-4ef6-b761-a52f6342293a
Kelly, Joanne Marie
b7094829-aeb1-4bc1-b64c-7b7c716f73b5
Somerville, Jane
b7f3973b-e643-413c-9b6a-a2f1ccd9937a
Zhang, Jin
27009b1e-dd46-4a6c-a3bc-d5a90246d9e9
Grey, Elisabeth B
29e3f997-95c1-45c1-959c-be1b94172059
Western, Max
7f55bcc2-c832-4e7c-97fb-22e21ad5ddfa
Ferrey, Anne
38b7fff0-a408-47f5-93ad-069d2678c8d1
Krusche, Adele
336ef9cd-ec58-4826-8eaa-9c9f6edbb0ee
Stuart, Beth
626862fc-892b-4f6d-9cbb-7a8d7172b209
Mutrie, Nanette
9c1f3f0a-434e-4275-a546-63d25201a86e
Robinson, Sian
6ada395c-a5e4-484b-b3a8-6760db7a48e4
Guiqing, Lily
89041c4d-4198-4723-b098-0f82a8b917fb
Griffiths, Gareth
7fd300c0-d279-4ff6-842d-aa1f2b9b864d
Robinson, Louise
488aea33-4475-4b1f-83f8-018bfcb56a1f
Rossor, Martin N.
dbde2557-152c-42ca-8a54-b50d0f18ef5e
Gallacher, John E.
e05d736b-eb13-4f6b-b8ca-6f417d60a6a7
Griffin, Simon J.
1f8d5095-3c10-4973-a2c4-84ce6415d118
Kendrick, Tony
c697a72c-c698-469d-8ac2-f00df40583e5
Rathod, Shanaya
b4dddbe5-e4aa-4069-bd03-20cd6332639c
Gudgin, Bernard
e832fb17-bfdd-42ab-a9dc-7312629c743e
Phillips, Rosemary
19c8044a-0290-4861-9416-df93fadd473d
Stokes, Tom
4c63a939-5880-467a-8068-55a524e3eaf0
Niven, John
c61ef2b8-226e-4ab3-918e-484d02a3826d
Little, Paul
1bf2d1f7-200c-47a5-ab16-fe5a8756a777
Yardley, Lucy
64be42c4-511d-484d-abaa-f8813452a22e

Smith, Kirsten, Bradbury, Katherine, Essery, Rosie, Pollet, Sebastien, Mowbray, Fiona, Slodkowska-Barabasz, Joanna, Denison-Day, James, Hayter, Victoria, Kelly, Joanne Marie, Somerville, Jane, Zhang, Jin, Grey, Elisabeth B, Western, Max, Ferrey, Anne, Krusche, Adele, Stuart, Beth, Mutrie, Nanette, Robinson, Sian, Guiqing, Lily, Griffiths, Gareth, Robinson, Louise, Rossor, Martin N., Gallacher, John E., Griffin, Simon J., Kendrick, Tony, Rathod, Shanaya, Gudgin, Bernard, Phillips, Rosemary, Stokes, Tom, Niven, John, Little, Paul and Yardley, Lucy (2020) Active Brains - a digital intervention to reduce cognitive decline in older adults: protocol for a feasibility randomised control trial. JMIR Research Protocols, 9 (11), [18929]. (doi:10.2196/18929). (In Press)

Record type: Article

Abstract

Background
Increasing physical activity, improving diet and doing 'brain training' exercises are associated with reduced cognitive decline in older adults. Here we describe a feasibility trial of the Active Brains intervention, an online digital intervention developed to support older adults to make these three healthy behaviour changes associated with cognitive health.

Objective
The Active Brains trial is a randomised feasibility trial that will test how accessible, acceptable and feasible the Active Brains intervention is and the effectiveness of the study procedures that we plan to use in our larger main trial.
Methods
The randomised controlled trial uses a parallel design. We will be trialling the intervention with two populations recruited through GP practices in England 2018-19: 1) older adults with signs of cognitive decline, 2) older adults without any cognitive decline. Trial participants will be randomly allocated to one of three study groups: 1) usual care or 2) the Active Brains intervention, or 3) the Active Brains website plus brief support from a trained coach (over the phone or by email). The main outcomes are performance on cognitive tasks, Quality of Life (using EQ-5D-5L), Instrumental Activities of Daily Living and diagnoses of dementia. Secondary outcomes (including depression, enablement and healthcare costs) and process measures (including qualitative interviews with participants and supporters) will also be collected.

Results
Results will be published in peer-reviewed journals, presented at conferences and shared at public engagement events. Data collection was completed in May 2020, and results will be reported in 2021.

Conclusions
The findings of this study will help us to identify and make important changes to the website, the support received or the study procedures before we progress to our main randomized phase III trial.

Ethics and dissemination
The trial has been approved by the NHS Research Ethics Committee (Reference 17/SC/0463). The results of this trial will be published in peer-reviewed journals and through conference presentations.

Trial registration number: ISRCTN 23758980

Text
RECONFeasProtocolPaperRevisionsUntracked - Accepted Manuscript
Available under License Creative Commons Attribution.
Download (397kB)

More information

Accepted/In Press date: 16 August 2020
Keywords: aging, behaviour change, cognitive health, digital intervention, e-health, feasibility, randomised trial

Identifiers

Local EPrints ID: 443886
URI: http://eprints.soton.ac.uk/id/eprint/443886
PURE UUID: f8856164-14e7-482b-b113-bd856161b8af
ORCID for Katherine Bradbury: ORCID iD orcid.org/0000-0001-5513-7571
ORCID for Sebastien Pollet: ORCID iD orcid.org/0000-0001-9924-9225
ORCID for Fiona Mowbray: ORCID iD orcid.org/0000-0002-3297-4163
ORCID for Jin Zhang: ORCID iD orcid.org/0000-0001-9583-6000
ORCID for Beth Stuart: ORCID iD orcid.org/0000-0001-5432-7437
ORCID for Gareth Griffiths: ORCID iD orcid.org/0000-0002-9579-8021
ORCID for Tony Kendrick: ORCID iD orcid.org/0000-0003-1618-9381
ORCID for Lucy Yardley: ORCID iD orcid.org/0000-0002-3853-883X

Catalogue record

Date deposited: 16 Sep 2020 16:34
Last modified: 10 Jan 2022 03:03

Export record

Altmetrics

Contributors

Author: Kirsten Smith
Author: Rosie Essery
Author: Fiona Mowbray ORCID iD
Author: Victoria Hayter
Author: Jane Somerville
Author: Jin Zhang ORCID iD
Author: Elisabeth B Grey
Author: Max Western
Author: Anne Ferrey
Author: Adele Krusche
Author: Beth Stuart ORCID iD
Author: Nanette Mutrie
Author: Sian Robinson
Author: Lily Guiqing
Author: Louise Robinson
Author: Martin N. Rossor
Author: John E. Gallacher
Author: Simon J. Griffin
Author: Tony Kendrick ORCID iD
Author: Shanaya Rathod
Author: Bernard Gudgin
Author: Rosemary Phillips
Author: Tom Stokes
Author: John Niven
Author: Paul Little
Author: Lucy Yardley ORCID iD

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×