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Prevention of acquisition of cytomegalovirus infection in pregnancy through hygiene-based behavioural interventions : a systematic review and gap analysis

Prevention of acquisition of cytomegalovirus infection in pregnancy through hygiene-based behavioural interventions : a systematic review and gap analysis
Prevention of acquisition of cytomegalovirus infection in pregnancy through hygiene-based behavioural interventions : a systematic review and gap analysis
Background: Congenital cytomegalovirus infection is the most common nongenetic cause of sensorineural hearing loss in childhood and an important cause of neurodisability. There is no licensed cytomegalovirus (CMV) vaccine and no antenatal treatment for congenital CMV that is routinely recommended in clinical practice in the United Kingdom.

Objectives: To review the published literature for studies that evaluated preventative hygiene-based interventions in pregnancy for their impact on knowledge about CMV prevention, the uptake of preventative behaviors or the acquisition of CMV in pregnancy.

Search strategy: Searches were carried out in Medical Literature Analysis and Retrieval System Online and Cumulative Index of Nursing and Allied Health Literature databases.

Selection criteria: All human studies, limited to women of childbearing age were included.

Data collection and analysis: Two reviewers independently assessed the quality of the methods and results of included articles. Extracted data were classified using Cochrane guidelines.

Main results: Seven studies met the inclusion criteria. These show that preventative measures are acceptable to pregnant women, can impact their behavior and have the potential to reduce CMV in pregnancy. They are limited by several factors; sample size, nonrandomized trial design and interventions that are beyond routine clinical practice.

Conclusions: An effective intervention that changes behavior in pregnancy and reduces the risk of CMV acquisition is needed as part of routine care. There is currently insufficient evidence about the form that this intervention should take.
0891-3668
949-954
Barber, Victoria
f8c6d6ff-ab0a-4e3d-9997-8b310bfb40f6
Calvert, Anna
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Vandrevala, Tushna
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Star, Caroline
6c77cbfa-699d-47a1-a8d5-d0bbef7e86a6
Khalil, Asma
6954aa6c-ddd6-4205-976e-fe834c6a860d
Griffiths, Paul
bf1dfc3d-551e-4ea0-b763-6f7010e96b7f
Heath, Paul T.
b9b6e0e4-6bd0-4c16-b9f6-607b00137fe4
Jones, Christine E.
48229079-8b58-4dcb-8374-d9481fe7b426
Barber, Victoria
f8c6d6ff-ab0a-4e3d-9997-8b310bfb40f6
Calvert, Anna
63594e74-2888-467a-9819-2816fd869220
Vandrevala, Tushna
45ccaf5a-cb30-40df-ba91-1ef166672468
Star, Caroline
6c77cbfa-699d-47a1-a8d5-d0bbef7e86a6
Khalil, Asma
6954aa6c-ddd6-4205-976e-fe834c6a860d
Griffiths, Paul
bf1dfc3d-551e-4ea0-b763-6f7010e96b7f
Heath, Paul T.
b9b6e0e4-6bd0-4c16-b9f6-607b00137fe4
Jones, Christine E.
48229079-8b58-4dcb-8374-d9481fe7b426

Barber, Victoria, Calvert, Anna, Vandrevala, Tushna, Star, Caroline, Khalil, Asma, Griffiths, Paul, Heath, Paul T. and Jones, Christine E. (2020) Prevention of acquisition of cytomegalovirus infection in pregnancy through hygiene-based behavioural interventions : a systematic review and gap analysis. Pediatric Infectious Disease Journal, 39 (10), 949-954. (doi:10.1097/INF.0000000000002763).

Record type: Article

Abstract

Background: Congenital cytomegalovirus infection is the most common nongenetic cause of sensorineural hearing loss in childhood and an important cause of neurodisability. There is no licensed cytomegalovirus (CMV) vaccine and no antenatal treatment for congenital CMV that is routinely recommended in clinical practice in the United Kingdom.

Objectives: To review the published literature for studies that evaluated preventative hygiene-based interventions in pregnancy for their impact on knowledge about CMV prevention, the uptake of preventative behaviors or the acquisition of CMV in pregnancy.

Search strategy: Searches were carried out in Medical Literature Analysis and Retrieval System Online and Cumulative Index of Nursing and Allied Health Literature databases.

Selection criteria: All human studies, limited to women of childbearing age were included.

Data collection and analysis: Two reviewers independently assessed the quality of the methods and results of included articles. Extracted data were classified using Cochrane guidelines.

Main results: Seven studies met the inclusion criteria. These show that preventative measures are acceptable to pregnant women, can impact their behavior and have the potential to reduce CMV in pregnancy. They are limited by several factors; sample size, nonrandomized trial design and interventions that are beyond routine clinical practice.

Conclusions: An effective intervention that changes behavior in pregnancy and reduces the risk of CMV acquisition is needed as part of routine care. There is currently insufficient evidence about the form that this intervention should take.

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PIDJ Main manuscript_resubmission_v3_AC_CJ - Accepted Manuscript
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Accepted/In Press date: 29 April 2020
Published date: 1 October 2020

Identifiers

Local EPrints ID: 443976
URI: http://eprints.soton.ac.uk/id/eprint/443976
ISSN: 0891-3668
PURE UUID: 83bc143f-47ea-44c0-8b66-64e76abb5bf0
ORCID for Christine E. Jones: ORCID iD orcid.org/0000-0003-1523-2368

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Date deposited: 18 Sep 2020 16:31
Last modified: 23 Jul 2022 04:59

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Contributors

Author: Victoria Barber
Author: Anna Calvert
Author: Tushna Vandrevala
Author: Caroline Star
Author: Asma Khalil
Author: Paul Griffiths
Author: Paul T. Heath

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