Ge on Si waveguide mid-infrared absorption spectroscopy of proteins and their aggregates
Ge on Si waveguide mid-infrared absorption spectroscopy of proteins and their aggregates
Specific proteins and their aggregates form toxic amyloid plaques and neurofibrillary tangles in the brains of people suffering from neurodegenerative diseases such as Alzheimer’s and Parkinson’s. It is important to study these conformational changes to identify and differentiate these diseases at an early stage so that timely medication is provided to patients. Mid-infrared spectroscopy can be used to monitor these changes by studying the line-shapes and the relative absorbances of amide bands present in proteins. This work focusses on the spectroscopy of the protein, Bovine Serum Albumin as an exemplar, and its aggregates using germanium on silicon waveguides in the 1900–1000 cm-1 (5.3–10.0 µm) spectral region.
4714-4722
Mittal, Vinita
fd5ee9dd-7770-416f-8f47-50ca158b39b0
Devitt, George
088c46c0-9dcf-4c83-acfd-16c6c9d0ca88
Nedeljković, Miloš
b64e21c2-1b95-479d-a35c-3456dff8c796
Carpenter, Lewis Glynn
0daa548e-0d42-4b06-b914-45bfbec41759
Chong, Harold
795aa67f-29e5-480f-b1bc-9bd5c0d558e1
Wilkinson, James S.
73483cf3-d9f2-4688-9b09-1c84257884ca
Mahajan, Sumeet
b131f40a-479e-4432-b662-19d60d4069e9
Mashanovich, Goran
c806e262-af80-4836-b96f-319425060051
1 August 2020
Mittal, Vinita
fd5ee9dd-7770-416f-8f47-50ca158b39b0
Devitt, George
088c46c0-9dcf-4c83-acfd-16c6c9d0ca88
Nedeljković, Miloš
b64e21c2-1b95-479d-a35c-3456dff8c796
Carpenter, Lewis Glynn
0daa548e-0d42-4b06-b914-45bfbec41759
Chong, Harold
795aa67f-29e5-480f-b1bc-9bd5c0d558e1
Wilkinson, James S.
73483cf3-d9f2-4688-9b09-1c84257884ca
Mahajan, Sumeet
b131f40a-479e-4432-b662-19d60d4069e9
Mashanovich, Goran
c806e262-af80-4836-b96f-319425060051
Mittal, Vinita, Devitt, George, Nedeljković, Miloš, Carpenter, Lewis Glynn, Chong, Harold, Wilkinson, James S., Mahajan, Sumeet and Mashanovich, Goran
(2020)
Ge on Si waveguide mid-infrared absorption spectroscopy of proteins and their aggregates.
Biomedical Optics Express, 11 (8), .
(doi:10.1364/BOE.398013).
Abstract
Specific proteins and their aggregates form toxic amyloid plaques and neurofibrillary tangles in the brains of people suffering from neurodegenerative diseases such as Alzheimer’s and Parkinson’s. It is important to study these conformational changes to identify and differentiate these diseases at an early stage so that timely medication is provided to patients. Mid-infrared spectroscopy can be used to monitor these changes by studying the line-shapes and the relative absorbances of amide bands present in proteins. This work focusses on the spectroscopy of the protein, Bovine Serum Albumin as an exemplar, and its aggregates using germanium on silicon waveguides in the 1900–1000 cm-1 (5.3–10.0 µm) spectral region.
Text
BME_accepted
- Accepted Manuscript
Restricted to Repository staff only
Request a copy
Text
boe-11-8-4714
- Version of Record
More information
Submitted date: 13 July 2020
Accepted/In Press date: 21 July 2020
e-pub ahead of print date: 28 July 2020
Published date: 1 August 2020
Identifiers
Local EPrints ID: 443985
URI: http://eprints.soton.ac.uk/id/eprint/443985
ISSN: 2156-7085
PURE UUID: 7c3e4aac-4e4d-43c1-8f25-4f657abd7d4b
Catalogue record
Date deposited: 18 Sep 2020 16:36
Last modified: 29 Oct 2024 02:45
Export record
Altmetrics
Download statistics
Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.
View more statistics
