Mittal, Vinita, Devitt, George, Nedeljković, Milos, Carpenter, Lewis Glynn, Chong, Harold, Wilkinson, James S., Mahajan, Sumeet and Mashanovich, Goran (2020) Ge on Si waveguide mid-infrared absorption spectroscopy of proteins and their aggregates. Biomedical Optics Express, 11 (8), 4714-4722. (doi:10.1364/BOE.398013).
Abstract
Specific proteins and their aggregates form toxic amyloid plaques and neurofibrillary tangles in the brains of people suffering from neurodegenerative diseases such as Alzheimer’s and Parkinson’s. It is important to study these conformational changes to identify and differentiate these diseases at an early stage so that timely medication is provided to patients. Mid-infrared spectroscopy can be used to monitor these changes by studying the line-shapes and the relative absorbances of amide bands present in proteins. This work focusses on the spectroscopy of the protein, Bovine Serum Albumin as an exemplar, and its aggregates using germanium on silicon waveguides in the 1900–1000 cm-1 (5.3–10.0 µm) spectral region.
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- Current Faculties > Faculty of Engineering and Physical Sciences > Zepler Institute for Photonics and Nanoelectronics > Nanophotonics Group > Photonic Systems Circuits and Sensors Group
Zepler Institute for Photonics and Nanoelectronics > Nanophotonics Group > Photonic Systems Circuits and Sensors Group - Current Faculties > Faculty of Engineering and Physical Sciences > School of Chemistry > Chemical Biology, Diagnostics and Therapeutics
School of Chemistry > Chemical Biology, Diagnostics and Therapeutics - Current Faculties > Faculty of Engineering and Physical Sciences > School of Electronics and Computer Science > Sustainable Electronic Technologies
School of Electronics and Computer Science > Sustainable Electronic Technologies - Current Faculties > Faculty of Environmental and Life Sciences > School of Biological Sciences > Neuroscience
School of Biological Sciences > Neuroscience
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