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Ge on Si waveguide mid-infrared absorption spectroscopy of proteins and their aggregates

Ge on Si waveguide mid-infrared absorption spectroscopy of proteins and their aggregates
Ge on Si waveguide mid-infrared absorption spectroscopy of proteins and their aggregates
Specific proteins and their aggregates form toxic amyloid plaques and neurofibrillary tangles in the brains of people suffering from neurodegenerative diseases such as Alzheimer’s and Parkinson’s. It is important to study these conformational changes to identify and differentiate these diseases at an early stage so that timely medication is provided to patients. Mid-infrared spectroscopy can be used to monitor these changes by studying the line-shapes and the relative absorbances of amide bands present in proteins. This work focusses on the spectroscopy of the protein, Bovine Serum Albumin as an exemplar, and its aggregates using germanium on silicon waveguides in the 1900–1000 cm-1 (5.3–10.0 µm) spectral region.
2156-7085
4714-4722
Mittal, Vinita
fd5ee9dd-7770-416f-8f47-50ca158b39b0
Devitt, George
088c46c0-9dcf-4c83-acfd-16c6c9d0ca88
Nedeljković, Milos
b64e21c2-1b95-479d-a35c-3456dff8c796
Carpenter, Lewis Glynn
0daa548e-0d42-4b06-b914-45bfbec41759
Chong, Harold
795aa67f-29e5-480f-b1bc-9bd5c0d558e1
Wilkinson, James S.
73483cf3-d9f2-4688-9b09-1c84257884ca
Mahajan, Sumeet
b131f40a-479e-4432-b662-19d60d4069e9
Mashanovich, Goran
c806e262-af80-4836-b96f-319425060051
Mittal, Vinita
fd5ee9dd-7770-416f-8f47-50ca158b39b0
Devitt, George
088c46c0-9dcf-4c83-acfd-16c6c9d0ca88
Nedeljković, Milos
b64e21c2-1b95-479d-a35c-3456dff8c796
Carpenter, Lewis Glynn
0daa548e-0d42-4b06-b914-45bfbec41759
Chong, Harold
795aa67f-29e5-480f-b1bc-9bd5c0d558e1
Wilkinson, James S.
73483cf3-d9f2-4688-9b09-1c84257884ca
Mahajan, Sumeet
b131f40a-479e-4432-b662-19d60d4069e9
Mashanovich, Goran
c806e262-af80-4836-b96f-319425060051

Mittal, Vinita, Devitt, George, Nedeljković, Milos, Carpenter, Lewis Glynn, Chong, Harold, Wilkinson, James S., Mahajan, Sumeet and Mashanovich, Goran (2020) Ge on Si waveguide mid-infrared absorption spectroscopy of proteins and their aggregates. Biomedical Optics Express, 11 (8), 4714-4722. (doi:10.1364/BOE.398013).

Record type: Article

Abstract

Specific proteins and their aggregates form toxic amyloid plaques and neurofibrillary tangles in the brains of people suffering from neurodegenerative diseases such as Alzheimer’s and Parkinson’s. It is important to study these conformational changes to identify and differentiate these diseases at an early stage so that timely medication is provided to patients. Mid-infrared spectroscopy can be used to monitor these changes by studying the line-shapes and the relative absorbances of amide bands present in proteins. This work focusses on the spectroscopy of the protein, Bovine Serum Albumin as an exemplar, and its aggregates using germanium on silicon waveguides in the 1900–1000 cm-1 (5.3–10.0 µm) spectral region.

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Submitted date: 13 July 2020
Accepted/In Press date: 21 July 2020
e-pub ahead of print date: 28 July 2020
Published date: 1 August 2020

Identifiers

Local EPrints ID: 443985
URI: http://eprints.soton.ac.uk/id/eprint/443985
ISSN: 2156-7085
PURE UUID: 7c3e4aac-4e4d-43c1-8f25-4f657abd7d4b
ORCID for Vinita Mittal: ORCID iD orcid.org/0000-0003-4836-5327
ORCID for George Devitt: ORCID iD orcid.org/0000-0001-7179-4459
ORCID for Milos Nedeljković: ORCID iD orcid.org/0000-0002-9170-7911
ORCID for Harold Chong: ORCID iD orcid.org/0000-0002-7110-5761
ORCID for James S. Wilkinson: ORCID iD orcid.org/0000-0003-4712-1697
ORCID for Sumeet Mahajan: ORCID iD orcid.org/0000-0001-8923-6666

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Date deposited: 18 Sep 2020 16:36
Last modified: 18 Feb 2021 17:41

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