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The infant pharyngeal microbiomes: origin, impact and manipulation

The infant pharyngeal microbiomes: origin, impact and manipulation
The infant pharyngeal microbiomes: origin, impact and manipulation
Purpose of review: there has been an exponential increase in research intoinfant microbiome evolution, and it appears that pharyngeal microbiota are associated with clinical phenotypes(e.g. infection and asthma). While broad consensus views are emerging, significant challenges and uncertainties remain.

Recent findings: infant pharyngeal microbiome research is limited by low biomass, high temporal diversity, and lack of agreed standards for sampling, DNA sequencing, and taxonomic reporting. Analysis of amplicon sequence variants and improvedcost and availability of whole genome sequencing are promising options for improving taxonomic resolution of such studies. Infant respiratory microbiomes arise, at least in part, from maternal flora (e.g. the respiratory tract and breastmilk), and are associated with environmental and clinical factors (e.g.mode of feeding and delivery, siblings, daycare attendance, birth season, and antibiotic usage). Interventional research to modify the infant pharyngeal microbiota hasrecentlybeen reported, using dietary supplements.

Summary: further work is needed to improve characterisation ofthe infant pharyngeal microbiomes, including routes of bacterial acquisition, role of environmental factors, and associations with disease phenotypes. Methodological standards are desirable to facilitate more reproducible, comparable research. Improved understanding may enable manipulation of infant pharyngeal microbiota to improve clinical outcomes.
0951-7375
548-555
Jones, Christine E
48229079-8b58-4dcb-8374-d9481fe7b426
Read, Robert
b5caca7b-0063-438a-b703-7ecbb6fc2b51
Theodosiou, Anastasia A.
12be2a94-90a5-47da-beba-bd7c5e99de94
Jones, Christine E
48229079-8b58-4dcb-8374-d9481fe7b426
Read, Robert
b5caca7b-0063-438a-b703-7ecbb6fc2b51
Theodosiou, Anastasia A.
12be2a94-90a5-47da-beba-bd7c5e99de94

Jones, Christine E, Read, Robert and Theodosiou, Anastasia A. (2020) The infant pharyngeal microbiomes: origin, impact and manipulation. Current Opinion in Infectious Diseases, 33 (6), 548-555. (doi:10.1097/QCO.0000000000000691).

Record type: Article

Abstract

Purpose of review: there has been an exponential increase in research intoinfant microbiome evolution, and it appears that pharyngeal microbiota are associated with clinical phenotypes(e.g. infection and asthma). While broad consensus views are emerging, significant challenges and uncertainties remain.

Recent findings: infant pharyngeal microbiome research is limited by low biomass, high temporal diversity, and lack of agreed standards for sampling, DNA sequencing, and taxonomic reporting. Analysis of amplicon sequence variants and improvedcost and availability of whole genome sequencing are promising options for improving taxonomic resolution of such studies. Infant respiratory microbiomes arise, at least in part, from maternal flora (e.g. the respiratory tract and breastmilk), and are associated with environmental and clinical factors (e.g.mode of feeding and delivery, siblings, daycare attendance, birth season, and antibiotic usage). Interventional research to modify the infant pharyngeal microbiota hasrecentlybeen reported, using dietary supplements.

Summary: further work is needed to improve characterisation ofthe infant pharyngeal microbiomes, including routes of bacterial acquisition, role of environmental factors, and associations with disease phenotypes. Methodological standards are desirable to facilitate more reproducible, comparable research. Improved understanding may enable manipulation of infant pharyngeal microbiota to improve clinical outcomes.

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More information

Accepted/In Press date: 15 September 2020
Published date: 1 December 2020

Identifiers

Local EPrints ID: 444018
URI: http://eprints.soton.ac.uk/id/eprint/444018
ISSN: 0951-7375
PURE UUID: 62d25dde-80ef-4c0c-8dcb-5b4f6f3da4ec
ORCID for Christine E Jones: ORCID iD orcid.org/0000-0003-1523-2368
ORCID for Robert Read: ORCID iD orcid.org/0000-0002-4297-6728

Catalogue record

Date deposited: 22 Sep 2020 16:31
Last modified: 23 Jun 2021 01:50

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