The University of Southampton
University of Southampton Institutional Repository
Warning ePrints Soton is experiencing an issue with some file downloads not being available. We are working hard to fix this. Please bear with us.

Targeted inhibition of mRNA translation initiation factors as a novel therapeutic strategy for mature B-cell neoplasms

Targeted inhibition of mRNA translation initiation factors as a novel therapeutic strategy for mature B-cell neoplasms
Targeted inhibition of mRNA translation initiation factors as a novel therapeutic strategy for mature B-cell neoplasms
Cancer development is frequently associated with dysregulation of mRNA translation to enhance both increased global protein synthesis and translation of specific mRNAs encoding oncoproteins. Thus, targeted inhibition of mRNA translation is viewed as a promising new approach for cancer therapy. In this article we review current progress in investigating dysregulation of mRNA translation initiation in mature B-cell neoplasms, focusing on chronic lymphocytic leukemia, follicular lymphoma and diffuse large B-cell lymphoma. We discuss mechanisms and regulation of mRNA translation, potential pathways by which genetic alterations and the tumor microenvironment alters mRNA translation in malignant B cells, preclinical evaluation of drugs targeted against specific eukaryotic initiation factors and current progress towards clinical development. Overall, inhibition of mRNA translation initiation factors is an exciting and promising area for development of novel targeted anti-tumor drugs.
2692-3114
Packham, Graham
fdabe56f-2c58-469c-aadf-38878f233394
Taylor, Joe
6a4a31d0-defc-4b85-b4bd-1292b356ef51
Yeomans, Alison
b47f0dfe-596f-4cef-b4b6-2233b7cdd899
Packham, Graham
fdabe56f-2c58-469c-aadf-38878f233394
Taylor, Joe
6a4a31d0-defc-4b85-b4bd-1292b356ef51
Yeomans, Alison
b47f0dfe-596f-4cef-b4b6-2233b7cdd899

Packham, Graham, Taylor, Joe and Yeomans, Alison (2020) Targeted inhibition of mRNA translation initiation factors as a novel therapeutic strategy for mature B-cell neoplasms. Exploration of Targeted Anti-Tumor Therapy, 1. (doi:10.37349/etat.2020.00002).

Record type: Article

Abstract

Cancer development is frequently associated with dysregulation of mRNA translation to enhance both increased global protein synthesis and translation of specific mRNAs encoding oncoproteins. Thus, targeted inhibition of mRNA translation is viewed as a promising new approach for cancer therapy. In this article we review current progress in investigating dysregulation of mRNA translation initiation in mature B-cell neoplasms, focusing on chronic lymphocytic leukemia, follicular lymphoma and diffuse large B-cell lymphoma. We discuss mechanisms and regulation of mRNA translation, potential pathways by which genetic alterations and the tumor microenvironment alters mRNA translation in malignant B cells, preclinical evaluation of drugs targeted against specific eukaryotic initiation factors and current progress towards clinical development. Overall, inhibition of mRNA translation initiation factors is an exciting and promising area for development of novel targeted anti-tumor drugs.

Text
Targeted inhibition of mRNA translation initiation factors as a novel therapeutic strategy for mature B-cell neoplasms - Accepted Manuscript
Available under License Creative Commons Attribution.
Download (3MB)

More information

Accepted/In Press date: 31 January 2020
Published date: 29 February 2020

Identifiers

Local EPrints ID: 444032
URI: http://eprints.soton.ac.uk/id/eprint/444032
ISSN: 2692-3114
PURE UUID: f44a3270-dd08-42ef-97d5-a0af97f06aea
ORCID for Graham Packham: ORCID iD orcid.org/0000-0002-9232-5691

Catalogue record

Date deposited: 23 Sep 2020 16:30
Last modified: 18 Feb 2021 16:55

Export record

Altmetrics

Contributors

Author: Graham Packham ORCID iD
Author: Joe Taylor
Author: Alison Yeomans

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×