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S93 Pulmonary matrix metalloproteinases and small airways disease in COPD – the origins of airflow obstruction?

S93 Pulmonary matrix metalloproteinases and small airways disease in COPD – the origins of airflow obstruction?
S93 Pulmonary matrix metalloproteinases and small airways disease in COPD – the origins of airflow obstruction?
Introduction and objectives
Matrix-metalloproteinases (MMPs) are proteolytic enzymes that can degrade the extra-cellular matrix (ECM) and drive tissue remodelling, key processes in the pathogenesis of COPD. The development of small airway disease and emphysema have been identified as critical mechanisms in the development of airflow obstruction but the contribution of MMPs in human disease is poorly characterised.
We investigated the role of MMPs in the lung by quantifying levels and determining relationships with the key pathological components of COPD, measured by CT, in patients and healthy controls.
Methods
24 mild and moderate COPD and 8 control subjects were enrolled onto the study and underwent bronchoalveolar lavage (BAL) and high resolution CT. We analysed levels of MMPs in BAL using a Luminex immunoassay. Image analysis, performed using VIDA Apollo software, quantitatively …
0040-6376
Ostridge, Kristoffer K
d2271bae-b078-4390-8919-8f8c0e20542c
Williams, N.
54385e30-6b7c-4eec-b904-bd3f9c9dedbb
Kim, V.
d45e843c-e9cc-46c4-998c-99e337ca9f36
Bennett, M.
e42f5213-4410-4284-9e96-74e359df6b19
Harden, S.
9a770018-262b-4e6e-8739-364a8e445622
Welch, Lindsay
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Bourne, Steve
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Coombs, N.
9e48793c-dd31-43b5-8170-1eb0abef85dd
Elkington, Paul
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Staples, Karl
e0e9d80f-0aed-435f-bd75-0c8818491fee
Wilkinson, Tom M.A.
9c51b529-00ce-45d2-b6e0-b623f61fdf82
Ostridge, Kristoffer K
d2271bae-b078-4390-8919-8f8c0e20542c
Williams, N.
54385e30-6b7c-4eec-b904-bd3f9c9dedbb
Kim, V.
d45e843c-e9cc-46c4-998c-99e337ca9f36
Bennett, M.
e42f5213-4410-4284-9e96-74e359df6b19
Harden, S.
9a770018-262b-4e6e-8739-364a8e445622
Welch, Lindsay
2884956f-21b6-47e7-8321-1409f5346cac
Bourne, Steve
7dbfb4c6-8d41-45d0-aac3-1e02b2f56d4e
Coombs, N.
9e48793c-dd31-43b5-8170-1eb0abef85dd
Elkington, Paul
60828c7c-3d32-47c9-9fcc-6c4c54c35a15
Staples, Karl
e0e9d80f-0aed-435f-bd75-0c8818491fee
Wilkinson, Tom M.A.
9c51b529-00ce-45d2-b6e0-b623f61fdf82

Ostridge, Kristoffer K, Williams, N., Kim, V., Bennett, M., Harden, S., Welch, Lindsay, Bourne, Steve, Coombs, N., Elkington, Paul, Staples, Karl and Wilkinson, Tom M.A. (2015) S93 Pulmonary matrix metalloproteinases and small airways disease in COPD – the origins of airflow obstruction? Thorax, 70 (Suppl 3).

Record type: Meeting abstract

Abstract

Introduction and objectives
Matrix-metalloproteinases (MMPs) are proteolytic enzymes that can degrade the extra-cellular matrix (ECM) and drive tissue remodelling, key processes in the pathogenesis of COPD. The development of small airway disease and emphysema have been identified as critical mechanisms in the development of airflow obstruction but the contribution of MMPs in human disease is poorly characterised.
We investigated the role of MMPs in the lung by quantifying levels and determining relationships with the key pathological components of COPD, measured by CT, in patients and healthy controls.
Methods
24 mild and moderate COPD and 8 control subjects were enrolled onto the study and underwent bronchoalveolar lavage (BAL) and high resolution CT. We analysed levels of MMPs in BAL using a Luminex immunoassay. Image analysis, performed using VIDA Apollo software, quantitatively …

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More information

Published date: 12 November 2015

Identifiers

Local EPrints ID: 444198
URI: http://eprints.soton.ac.uk/id/eprint/444198
ISSN: 0040-6376
PURE UUID: fe2c682f-7d80-461d-857e-6dae2d578bee
ORCID for Lindsay Welch: ORCID iD orcid.org/0000-0001-5564-2252
ORCID for Paul Elkington: ORCID iD orcid.org/0000-0003-0390-0613
ORCID for Karl Staples: ORCID iD orcid.org/0000-0003-3844-6457

Catalogue record

Date deposited: 01 Oct 2020 16:34
Last modified: 18 Feb 2021 17:42

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Contributors

Author: Kristoffer K Ostridge
Author: N. Williams
Author: V. Kim
Author: M. Bennett
Author: S. Harden
Author: Lindsay Welch ORCID iD
Author: Steve Bourne
Author: N. Coombs
Author: Paul Elkington ORCID iD
Author: Karl Staples ORCID iD
Author: Tom M.A. Wilkinson

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