Bone-marrow-derived mesenchymal stromal cells: from basic biology to applications in bone tissue engineering and bone regeneration
Bone-marrow-derived mesenchymal stromal cells: from basic biology to applications in bone tissue engineering and bone regeneration
Bone marrow provides a rich source of mesenchymal stromal cells (MSCs), which have the remarkable capacity for cell and tissue regeneration. Since their initial discovery in the guinea pig almost 50 years ago, bone-marrow-derived MSCs have been extensively studied in animals and humans. Several subpopulations have been characterized with the aim to isolate, enrich, and identify the cells with stem-cell properties and immunomodulatory actions, which are important for regenerative medicine. In this chapter, we review the properties of bone-marrow-derived MSCs with a focus on the preclinical setting and discuss their applications for bone tissue engineering and bone regeneration.
139-192
Zupan, J.
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Tang, Daniel Kee Oon
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Oreffo, Richard
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Redl, H.
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Presen, Darja Marolt
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20 August 2020
Zupan, J.
fd959d08-8fb5-4fd7-9201-1c89aadc6a7d
Tang, Daniel Kee Oon
7c6f7720-2abe-4be7-a51e-fd20d32a26c3
Oreffo, Richard
ff9fff72-6855-4d0f-bfb2-311d0e8f3778
Redl, H.
7164e93c-c525-4e94-90a5-dbbea536fc8d
Presen, Darja Marolt
58d3bbd4-ce7c-40d9-bf38-1eb66a32b8a3
Zupan, J., Tang, Daniel Kee Oon, Oreffo, Richard, Redl, H. and Presen, Darja Marolt
(2020)
Bone-marrow-derived mesenchymal stromal cells: from basic biology to applications in bone tissue engineering and bone regeneration.
In,
Gimble, Jeffrey M., Marolt Presen, Darja, Oreffo, Richard O.C., Wolbank, Susanne and Redl, Heinz
(eds.)
Cell Engineering and Regeneration.
(Reference Series in Biomedical Engineering)
Springer, .
(doi:10.1007/978-3-319-08831-0_7).
Record type:
Book Section
Abstract
Bone marrow provides a rich source of mesenchymal stromal cells (MSCs), which have the remarkable capacity for cell and tissue regeneration. Since their initial discovery in the guinea pig almost 50 years ago, bone-marrow-derived MSCs have been extensively studied in animals and humans. Several subpopulations have been characterized with the aim to isolate, enrich, and identify the cells with stem-cell properties and immunomodulatory actions, which are important for regenerative medicine. In this chapter, we review the properties of bone-marrow-derived MSCs with a focus on the preclinical setting and discuss their applications for bone tissue engineering and bone regeneration.
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More information
Accepted/In Press date: 11 March 2020
e-pub ahead of print date: 19 August 2020
Published date: 20 August 2020
Identifiers
Local EPrints ID: 444227
URI: http://eprints.soton.ac.uk/id/eprint/444227
PURE UUID: 831c0833-17ca-429c-8cec-c7fca5d194df
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Date deposited: 01 Oct 2020 16:34
Last modified: 13 Dec 2021 02:46
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Contributors
Author:
J. Zupan
Author:
Daniel Kee Oon Tang
Author:
H. Redl
Author:
Darja Marolt Presen
Editor:
Jeffrey M. Gimble
Editor:
Darja Marolt Presen
Editor:
Richard O.C. Oreffo
Editor:
Susanne Wolbank
Editor:
Heinz Redl
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