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Bone-marrow-derived mesenchymal stromal cells: from basic biology to applications in bone tissue engineering and bone regeneration

Bone-marrow-derived mesenchymal stromal cells: from basic biology to applications in bone tissue engineering and bone regeneration
Bone-marrow-derived mesenchymal stromal cells: from basic biology to applications in bone tissue engineering and bone regeneration
Bone marrow provides a rich source of mesenchymal stromal cells (MSCs), which have the remarkable capacity for cell and tissue regeneration. Since their initial discovery in the guinea pig almost 50 years ago, bone-marrow-derived MSCs have been extensively studied in animals and humans. Several subpopulations have been characterized with the aim to isolate, enrich, and identify the cells with stem-cell properties and immunomodulatory actions, which are important for regenerative medicine. In this chapter, we review the properties of bone-marrow-derived MSCs with a focus on the preclinical setting and discuss their applications for bone tissue engineering and bone regeneration.
139-192
Springer
Zupan, J.
fd959d08-8fb5-4fd7-9201-1c89aadc6a7d
Tang, Daniel Kee Oon
7c6f7720-2abe-4be7-a51e-fd20d32a26c3
Oreffo, Richard
ff9fff72-6855-4d0f-bfb2-311d0e8f3778
Redl, H.
7164e93c-c525-4e94-90a5-dbbea536fc8d
Presen, Darja Marolt
58d3bbd4-ce7c-40d9-bf38-1eb66a32b8a3
Gimble, Jeffrey M.
Marolt Presen, Darja
Oreffo, Richard O.C.
Wolbank, Susanne
Redl, Heinz
Zupan, J.
fd959d08-8fb5-4fd7-9201-1c89aadc6a7d
Tang, Daniel Kee Oon
7c6f7720-2abe-4be7-a51e-fd20d32a26c3
Oreffo, Richard
ff9fff72-6855-4d0f-bfb2-311d0e8f3778
Redl, H.
7164e93c-c525-4e94-90a5-dbbea536fc8d
Presen, Darja Marolt
58d3bbd4-ce7c-40d9-bf38-1eb66a32b8a3
Gimble, Jeffrey M.
Marolt Presen, Darja
Oreffo, Richard O.C.
Wolbank, Susanne
Redl, Heinz

Zupan, J., Tang, Daniel Kee Oon, Oreffo, Richard, Redl, H. and Presen, Darja Marolt (2020) Bone-marrow-derived mesenchymal stromal cells: from basic biology to applications in bone tissue engineering and bone regeneration. In, Gimble, Jeffrey M., Marolt Presen, Darja, Oreffo, Richard O.C., Wolbank, Susanne and Redl, Heinz (eds.) Cell Engineering and Regeneration. (Reference Series in Biomedical Engineering, , (doi:10.1007/978-3-319-08831-0_7)) Springer, pp. 139-192. (doi:10.1007/978-3-319-08831-0_7).

Record type: Book Section

Abstract

Bone marrow provides a rich source of mesenchymal stromal cells (MSCs), which have the remarkable capacity for cell and tissue regeneration. Since their initial discovery in the guinea pig almost 50 years ago, bone-marrow-derived MSCs have been extensively studied in animals and humans. Several subpopulations have been characterized with the aim to isolate, enrich, and identify the cells with stem-cell properties and immunomodulatory actions, which are important for regenerative medicine. In this chapter, we review the properties of bone-marrow-derived MSCs with a focus on the preclinical setting and discuss their applications for bone tissue engineering and bone regeneration.

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More information

Accepted/In Press date: 11 March 2020
e-pub ahead of print date: 19 August 2020
Published date: 20 August 2020

Identifiers

Local EPrints ID: 444227
URI: http://eprints.soton.ac.uk/id/eprint/444227
PURE UUID: 831c0833-17ca-429c-8cec-c7fca5d194df
ORCID for Richard Oreffo: ORCID iD orcid.org/0000-0001-5995-6726

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Date deposited: 01 Oct 2020 16:34
Last modified: 18 Feb 2021 16:54

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