Zupan, J., Tang, Daniel Kee Oon, Oreffo, Richard, Redl, H. and Presen, Darja Marolt (2020) Bone-marrow-derived mesenchymal stromal cells: from basic biology to applications in bone tissue engineering and bone regeneration. In, Gimble, Jeffrey M., Marolt Presen, Darja, Oreffo, Richard O.C., Wolbank, Susanne and Redl, Heinz (eds.) Cell Engineering and Regeneration. (Reference Series in Biomedical Engineering, , (doi:10.1007/978-3-319-08831-0_7)) Springer, pp. 139-192. (doi:10.1007/978-3-319-08831-0_7).
Abstract
Bone marrow provides a rich source of mesenchymal stromal cells (MSCs), which have the remarkable capacity for cell and tissue regeneration. Since their initial discovery in the guinea pig almost 50 years ago, bone-marrow-derived MSCs have been extensively studied in animals and humans. Several subpopulations have been characterized with the aim to isolate, enrich, and identify the cells with stem-cell properties and immunomodulatory actions, which are important for regenerative medicine. In this chapter, we review the properties of bone-marrow-derived MSCs with a focus on the preclinical setting and discuss their applications for bone tissue engineering and bone regeneration.
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- Faculties (pre 2018 reorg) > Faculty of Engineering and the Environment (pre 2018 reorg) > Southampton Marine & Maritime Institute (pre 2018 reorg)
- Faculties (pre 2018 reorg) > Faculty of Natural and Environmental Sciences (pre 2018 reorg) > Institute for Life Sciences (pre 2018 reorg)
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Institute for Life Sciences > Institute for Life Sciences (pre 2018 reorg) - Current Faculties > Faculty of Medicine > Human Development and Health
Human Development and Health
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