Bone-marrow-derived mesenchymal stromal cells: from basic biology to applications in bone tissue engineering and bone regeneration

Zupan, J., Tang, Daniel Kee Oon, Oreffo, Richard, Redl, H. and Presen, Darja Marolt (2020) Bone-marrow-derived mesenchymal stromal cells: from basic biology to applications in bone tissue engineering and bone regeneration. In, Gimble, Jeffrey M., Marolt Presen, Darja, Oreffo, Richard O.C., Wolbank, Susanne and Redl, Heinz (eds.) Cell Engineering and Regeneration. (Reference Series in Biomedical Engineering) Springer, pp. 139-192. (doi:10.1007/978-3-319-08831-0_7).

Abstract

Bone marrow provides a rich source of mesenchymal stromal cells (MSCs), which have the remarkable capacity for cell and tissue regeneration. Since their initial discovery in the guinea pig almost 50 years ago, bone-marrow-derived MSCs have been extensively studied in animals and humans. Several subpopulations have been characterized with the aim to isolate, enrich, and identify the cells with stem-cell properties and immunomodulatory actions, which are important for regenerative medicine. In this chapter, we review the properties of bone-marrow-derived MSCs with a focus on the preclinical setting and discuss their applications for bone tissue engineering and bone regeneration.

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Contributors

Author: Richard Oreffo

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