Association between exposure to pesticides and ADHD or Autism Spectrum Disorder: a systematic review of the literature
Association between exposure to pesticides and ADHD or Autism Spectrum Disorder: a systematic review of the literature
Objective:
To conduct a systematic review of studies assessing the relationship between exposure to pesticides and ADHD or Autism Spectrum Disorder (ASD).
Methods:
Based on a pre-registered protocol in PROPSERO (CRD42018107847), we searched PubMed, Ovid databases, and ISI Web of Knowledge with no date/language/document type restrictions, up to May 2019. The Newcastle Ottawa Scale was used to assess study quality.
Results:
Among the 29 retained studies, 13 focused on ADHD, 14 on ASD, and two on both disorders. Ten studies reported a significant association between exposure to pesticides and ADHD/ADHD symptoms and 12 studies found a significant association with ASD/ASD traits. The strengths of the association and the possible confounders controlled for varied substantially across studies.
Conclusion:
Whilst there is some evidence suggesting a possible link between pesticides and ADHD/ASD, heterogeneity across studies prevents firm conclusions. We provide methodological indications for future studies.
ADHD, pesticides, systematic review
1-24
Tessari, Luca
2a879481-c19e-4fc9-8af0-474970992083
Angriman, Marco
3520e752-d35c-461f-80f4-b31203319cef
Díaz-Román, Amparo
47ad1105-3105-4a04-a4d1-f17eb8a36596
Zhang, Junhua
0e084511-6f1c-4c1b-8b1b-971a840955d6
Conca, Andreas
144c9e1e-707b-4681-9cfe-23869be7042c
Cortese, Samuele
53d4bf2c-4e0e-4c77-9385-218350560fdb
Tessari, Luca
2a879481-c19e-4fc9-8af0-474970992083
Angriman, Marco
3520e752-d35c-461f-80f4-b31203319cef
Díaz-Román, Amparo
47ad1105-3105-4a04-a4d1-f17eb8a36596
Zhang, Junhua
0e084511-6f1c-4c1b-8b1b-971a840955d6
Conca, Andreas
144c9e1e-707b-4681-9cfe-23869be7042c
Cortese, Samuele
53d4bf2c-4e0e-4c77-9385-218350560fdb
Tessari, Luca, Angriman, Marco, Díaz-Román, Amparo, Zhang, Junhua, Conca, Andreas and Cortese, Samuele
(2020)
Association between exposure to pesticides and ADHD or Autism Spectrum Disorder: a systematic review of the literature.
Journal of Attention Disorders, .
(doi:10.1177/1087054720940402).
Abstract
Objective:
To conduct a systematic review of studies assessing the relationship between exposure to pesticides and ADHD or Autism Spectrum Disorder (ASD).
Methods:
Based on a pre-registered protocol in PROPSERO (CRD42018107847), we searched PubMed, Ovid databases, and ISI Web of Knowledge with no date/language/document type restrictions, up to May 2019. The Newcastle Ottawa Scale was used to assess study quality.
Results:
Among the 29 retained studies, 13 focused on ADHD, 14 on ASD, and two on both disorders. Ten studies reported a significant association between exposure to pesticides and ADHD/ADHD symptoms and 12 studies found a significant association with ASD/ASD traits. The strengths of the association and the possible confounders controlled for varied substantially across studies.
Conclusion:
Whilst there is some evidence suggesting a possible link between pesticides and ADHD/ASD, heterogeneity across studies prevents firm conclusions. We provide methodological indications for future studies.
Text
Tessari JAD 2020
- Accepted Manuscript
Text
Tessari Table 2
- Accepted Manuscript
More information
Accepted/In Press date: 11 June 2020
e-pub ahead of print date: 22 July 2020
Additional Information:
Publisher Copyright:
© The Author(s) 2020.
Keywords:
ADHD, pesticides, systematic review
Identifiers
Local EPrints ID: 444242
URI: http://eprints.soton.ac.uk/id/eprint/444242
ISSN: 1087-0547
PURE UUID: d4f26b83-859a-4baf-a8e2-5b5c4664ca16
Catalogue record
Date deposited: 02 Oct 2020 16:31
Last modified: 17 Mar 2024 03:37
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Contributors
Author:
Luca Tessari
Author:
Marco Angriman
Author:
Amparo Díaz-Román
Author:
Junhua Zhang
Author:
Andreas Conca
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