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Association between dietary patterns and renal function in a cross-sectional study using baseline data from the ELSA-Brasil cohort

Association between dietary patterns and renal function in a cross-sectional study using baseline data from the ELSA-Brasil cohort
Association between dietary patterns and renal function in a cross-sectional study using baseline data from the ELSA-Brasil cohort
Previous analyses of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) identified four main dietary patterns (DP). The aim of this study was to explore the association between the previously defined DP and renal function (RF). A cross-sectional study using the ELSA-Brasil baseline data was carried out. DP ("traditional", "fruits and vegetables", "bakery", and "low sugar/low fat), metabolic syndrome (MS) using the Joint Interim Statement criteria, microalbuminuria (MA), and glomerular filtration rate (eGFR) through the CKD-EPI equation were evaluated. Abnormal RF was defined as eGFR<60 mL·min-1·(1.73 m2)-1 and MA≥3.0 mg/dL. Factors associated with RF were determined and mediation analysis was performed to investigate the association between DP, MS, and RF. A total of 15,105 participants were recruited, with a mean age of 52±9 years; 8,134 participants (54%) were females. The mediation analysis identified indirect associations between "bakery" and "fruits and vegetables", and both were associated with decreased eGFR and albuminuria in both genders, compared with "traditional" and "low sugar/low fat" patterns in the general population. There was a direct association of the "bakery" pattern with MA in men (OR: 1.17, 95%CI: 1.92-1.48). The "fruits and vegetables" pattern also showed a direct association with reduced eGFR in women (OR: 1.65, 95%CI: 1.28-2.12), although there was no significance after adjustment. The "fruits and vegetables" and "bakery" DPs were associated with renal dysfunction. The only independent, direct association was between "bakery" DP and MA in men, raising concerns about DP and renal damage in men.
Albuminuria, Dietary pattern, Feeding behavior, Glomerular filtration rate, Kidney diseases
0100-879X
1-9
Silva Junior, Geraldo
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Fraser, Simon
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Xavier, Rosa
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Mota, Rosa
c7d1f24d-ec99-4f56-b363-b6e2935fbf61
Lopes, Antonio
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Mill, Jose
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Barreto, Sandhi
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Luft, Vivian
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Chor, Dora
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Santos, Carlos
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Lotufo, Paulo
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Matos, Sheila
d1839cbe-9a86-4e45-ac46-40fc749aab2f
Silva Junior, Geraldo
d9a38364-e9b7-4436-8341-1f5361412f67
Fraser, Simon
135884b6-8737-4e8a-a98c-5d803ac7a2dc
Xavier, Rosa
2b7f8a33-e449-4e97-8410-5993c89f6c45
Mota, Rosa
c7d1f24d-ec99-4f56-b363-b6e2935fbf61
Lopes, Antonio
650f6744-8869-4ab8-ab32-ea2bbddc3b53
Mill, Jose
325dce40-efa6-4524-a426-53ae886144ac
Barreto, Sandhi
5fc91c63-922b-4534-8bad-5576f5335a6c
Luft, Vivian
422d135d-1446-4216-ac06-dbaab020c3a8
Chor, Dora
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Santos, Carlos
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Lotufo, Paulo
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Matos, Sheila
d1839cbe-9a86-4e45-ac46-40fc749aab2f

Silva Junior, Geraldo, Fraser, Simon, Xavier, Rosa, Mota, Rosa, Lopes, Antonio, Mill, Jose, Barreto, Sandhi, Luft, Vivian, Chor, Dora, Santos, Carlos, Lotufo, Paulo and Matos, Sheila (2020) Association between dietary patterns and renal function in a cross-sectional study using baseline data from the ELSA-Brasil cohort. Brazilian Journal of Medical and Biological Research, 53 (12), 1-9, [e10230]. (doi:10.1590/1414-431X202010230).

Record type: Article

Abstract

Previous analyses of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) identified four main dietary patterns (DP). The aim of this study was to explore the association between the previously defined DP and renal function (RF). A cross-sectional study using the ELSA-Brasil baseline data was carried out. DP ("traditional", "fruits and vegetables", "bakery", and "low sugar/low fat), metabolic syndrome (MS) using the Joint Interim Statement criteria, microalbuminuria (MA), and glomerular filtration rate (eGFR) through the CKD-EPI equation were evaluated. Abnormal RF was defined as eGFR<60 mL·min-1·(1.73 m2)-1 and MA≥3.0 mg/dL. Factors associated with RF were determined and mediation analysis was performed to investigate the association between DP, MS, and RF. A total of 15,105 participants were recruited, with a mean age of 52±9 years; 8,134 participants (54%) were females. The mediation analysis identified indirect associations between "bakery" and "fruits and vegetables", and both were associated with decreased eGFR and albuminuria in both genders, compared with "traditional" and "low sugar/low fat" patterns in the general population. There was a direct association of the "bakery" pattern with MA in men (OR: 1.17, 95%CI: 1.92-1.48). The "fruits and vegetables" pattern also showed a direct association with reduced eGFR in women (OR: 1.65, 95%CI: 1.28-2.12), although there was no significance after adjustment. The "fruits and vegetables" and "bakery" DPs were associated with renal dysfunction. The only independent, direct association was between "bakery" DP and MA in men, raising concerns about DP and renal damage in men.

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More information

Accepted/In Press date: 24 July 2020
e-pub ahead of print date: 30 October 2020
Published date: 2020
Keywords: Albuminuria, Dietary pattern, Feeding behavior, Glomerular filtration rate, Kidney diseases

Identifiers

Local EPrints ID: 444294
URI: http://eprints.soton.ac.uk/id/eprint/444294
ISSN: 0100-879X
PURE UUID: 54dd3c64-598e-4280-9b82-00e85a7b0818
ORCID for Simon Fraser: ORCID iD orcid.org/0000-0002-4172-4406

Catalogue record

Date deposited: 09 Oct 2020 16:33
Last modified: 09 Jan 2022 06:53

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Contributors

Author: Geraldo Silva Junior
Author: Simon Fraser ORCID iD
Author: Rosa Xavier
Author: Rosa Mota
Author: Antonio Lopes
Author: Jose Mill
Author: Sandhi Barreto
Author: Vivian Luft
Author: Dora Chor
Author: Carlos Santos
Author: Paulo Lotufo
Author: Sheila Matos

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