Solid-phase synthesis in the twenty-first century
Solid-phase synthesis in the twenty-first century
Solid-phase synthesis is a powerful tool for achieving high-throughput chemistry. This review discusses recent diverse examples from my group: the solid-phase synthesis of unsymmetrical guanidines, polymer-supported versions of cyclooctadiene and 9-BBN, a triflate-like linker, the synthesis of tetrahydro-?-carbolines by the acyliminium Pictet-Spengler reaction, and a total synthesis of the anti my cobacterial cyclic depsipeptide natural product kahalalide A.
solid-phase synthesis, combinatorial chemistry, guanidines, polymer-supported reagents, traceless cleavage, alkaloids, pictet-spengler reaction, depsipeptides, natural-products, demethoxyfumitremorgin-c, cyclative cleavage, organic-synthesis, linker
3-10
Ganesan, A.
62aa5a87-9308-4383-8686-99726b6bcfb9
2006
Ganesan, A.
62aa5a87-9308-4383-8686-99726b6bcfb9
Ganesan, A.
(2006)
Solid-phase synthesis in the twenty-first century.
Mini-Reviews in Medicinal Chemistry, 6 (1), .
Abstract
Solid-phase synthesis is a powerful tool for achieving high-throughput chemistry. This review discusses recent diverse examples from my group: the solid-phase synthesis of unsymmetrical guanidines, polymer-supported versions of cyclooctadiene and 9-BBN, a triflate-like linker, the synthesis of tetrahydro-?-carbolines by the acyliminium Pictet-Spengler reaction, and a total synthesis of the anti my cobacterial cyclic depsipeptide natural product kahalalide A.
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Published date: 2006
Keywords:
solid-phase synthesis, combinatorial chemistry, guanidines, polymer-supported reagents, traceless cleavage, alkaloids, pictet-spengler reaction, depsipeptides, natural-products, demethoxyfumitremorgin-c, cyclative cleavage, organic-synthesis, linker
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Local EPrints ID: 44448
URI: http://eprints.soton.ac.uk/id/eprint/44448
ISSN: 1389-5575
PURE UUID: 129bceac-6472-4b70-8b99-5927bf49f9d8
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Date deposited: 07 Mar 2007
Last modified: 08 Jan 2022 15:58
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Author:
A. Ganesan
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