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Solid-phase synthesis in the twenty-first century

Solid-phase synthesis in the twenty-first century
Solid-phase synthesis in the twenty-first century
Solid-phase synthesis is a powerful tool for achieving high-throughput chemistry. This review discusses recent diverse examples from my group: the solid-phase synthesis of unsymmetrical guanidines, polymer-supported versions of cyclooctadiene and 9-BBN, a triflate-like linker, the synthesis of tetrahydro-?-carbolines by the acyliminium Pictet-Spengler reaction, and a total synthesis of the anti my cobacterial cyclic depsipeptide natural product kahalalide A.
solid-phase synthesis, combinatorial chemistry, guanidines, polymer-supported reagents, traceless cleavage, alkaloids, pictet-spengler reaction, depsipeptides, natural-products, demethoxyfumitremorgin-c, cyclative cleavage, organic-synthesis, linker
1389-5575
3-10
Ganesan, A.
62aa5a87-9308-4383-8686-99726b6bcfb9
Ganesan, A.
62aa5a87-9308-4383-8686-99726b6bcfb9

Ganesan, A. (2006) Solid-phase synthesis in the twenty-first century. Mini-Reviews in Medicinal Chemistry, 6 (1), 3-10.

Record type: Article

Abstract

Solid-phase synthesis is a powerful tool for achieving high-throughput chemistry. This review discusses recent diverse examples from my group: the solid-phase synthesis of unsymmetrical guanidines, polymer-supported versions of cyclooctadiene and 9-BBN, a triflate-like linker, the synthesis of tetrahydro-?-carbolines by the acyliminium Pictet-Spengler reaction, and a total synthesis of the anti my cobacterial cyclic depsipeptide natural product kahalalide A.

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More information

Published date: 2006
Keywords: solid-phase synthesis, combinatorial chemistry, guanidines, polymer-supported reagents, traceless cleavage, alkaloids, pictet-spengler reaction, depsipeptides, natural-products, demethoxyfumitremorgin-c, cyclative cleavage, organic-synthesis, linker

Identifiers

Local EPrints ID: 44448
URI: http://eprints.soton.ac.uk/id/eprint/44448
ISSN: 1389-5575
PURE UUID: 129bceac-6472-4b70-8b99-5927bf49f9d8

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Date deposited: 07 Mar 2007
Last modified: 13 Mar 2019 21:07

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