Unlabeled far-field Deeply Subwavelength Topological Microscopy (DSTM)
Unlabeled far-field Deeply Subwavelength Topological Microscopy (DSTM)
A nonintrusive far-field optical microscopy resolving structures at the nanometer scale would revolutionize biomedicine and nanotechnology but is not yet available. Here, a new type of microscopy is introduced, which reveals the fine structure of an object through its far-field scattering pattern under illumination with light containing deeply subwavelength singularity features. The object is reconstructed by a neural network trained on a large number of scattering events. In numerical experiments on imaging of a dimer, resolving powers better than λ/200, i.e., two orders of magnitude beyond the conventional “diffraction limit” of λ/2, are demonstrated. It is shown that imaging is tolerant to noise and is achievable with low dynamic range light intensity detectors. Proof-of-principle experimental confirmation of DSTM is provided with a training set of small size, yet sufficient to achieve resolution five-fold better than the diffraction limit. In principle, deep learning reconstruction can be extended to objects of random shape and shall be particularly efficient in microscopy of a priori known shapes, such as those found in routine tasks of machine vision, smart manufacturing, and particle counting for life sciences applications.
machine learning, microscopy, superoscillations, superresolution, unlabeled
Pu, Tanchao
89eb5a37-31bf-469a-ae29-c871d5d25c65
Ou, Jun-Yu
3fb703e3-b222-46d2-b4ee-75f296d9d64d
Savinov, Vassili
147c7954-4636-4438-a305-cd78539f7c0a
Yuan, Guanghui
d7af6f06-7da9-41ef-b7f9-cfe09e55fcaa
Papasimakis, Nikitas
f416bfa9-544c-4a3e-8a2d-bc1c11133a51
Zheludev, Nikolai
32fb6af7-97e4-4d11-bca6-805745e40cc6
Pu, Tanchao
89eb5a37-31bf-469a-ae29-c871d5d25c65
Ou, Jun-Yu
3fb703e3-b222-46d2-b4ee-75f296d9d64d
Savinov, Vassili
147c7954-4636-4438-a305-cd78539f7c0a
Yuan, Guanghui
d7af6f06-7da9-41ef-b7f9-cfe09e55fcaa
Papasimakis, Nikitas
f416bfa9-544c-4a3e-8a2d-bc1c11133a51
Zheludev, Nikolai
32fb6af7-97e4-4d11-bca6-805745e40cc6
Pu, Tanchao, Ou, Jun-Yu, Savinov, Vassili, Yuan, Guanghui, Papasimakis, Nikitas and Zheludev, Nikolai
(2020)
Unlabeled far-field Deeply Subwavelength Topological Microscopy (DSTM).
Advanced Science.
(doi:10.1002/advs.202002886).
Abstract
A nonintrusive far-field optical microscopy resolving structures at the nanometer scale would revolutionize biomedicine and nanotechnology but is not yet available. Here, a new type of microscopy is introduced, which reveals the fine structure of an object through its far-field scattering pattern under illumination with light containing deeply subwavelength singularity features. The object is reconstructed by a neural network trained on a large number of scattering events. In numerical experiments on imaging of a dimer, resolving powers better than λ/200, i.e., two orders of magnitude beyond the conventional “diffraction limit” of λ/2, are demonstrated. It is shown that imaging is tolerant to noise and is achievable with low dynamic range light intensity detectors. Proof-of-principle experimental confirmation of DSTM is provided with a training set of small size, yet sufficient to achieve resolution five-fold better than the diffraction limit. In principle, deep learning reconstruction can be extended to objects of random shape and shall be particularly efficient in microscopy of a priori known shapes, such as those found in routine tasks of machine vision, smart manufacturing, and particle counting for life sciences applications.
Text
DSTM Revised manuscript
- Accepted Manuscript
More information
Accepted/In Press date: 29 September 2020
e-pub ahead of print date: 17 November 2020
Keywords:
machine learning, microscopy, superoscillations, superresolution, unlabeled
Identifiers
Local EPrints ID: 444503
URI: http://eprints.soton.ac.uk/id/eprint/444503
ISSN: 2198-3844
PURE UUID: d8499baa-0298-4819-a057-da78100fa25f
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Date deposited: 22 Oct 2020 16:30
Last modified: 21 Nov 2024 03:01
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