The University of Southampton
University of Southampton Institutional Repository
Warning ePrints Soton is experiencing an issue with some file downloads not being available. We are working hard to fix this. Please bear with us.

Inflammation at the tissue-electrode interface in a case of rapid deterioration in hearing performance leading to explant after cochlear implantation

Inflammation at the tissue-electrode interface in a case of rapid deterioration in hearing performance leading to explant after cochlear implantation
Inflammation at the tissue-electrode interface in a case of rapid deterioration in hearing performance leading to explant after cochlear implantation
Objective: The reasons for soft failure after cochlear implantation require investigation. This study proposes a method to study and characterize the tissue response to the array in a case of soft failure in a person undergoing reimplantation.

Case: The woman in her 50s, with an underlying autoimmune condition, received a cochlear implant using hearing preservation technique after developing profound hearing loss more than 2 kHz with a moderate loss of less than 500 Hz over a 10-year period. The case was identified as a soft failure due to deteriorating performance, discomfort, and migration over the 10 months after implantation. Impedance telemetry, speech perception measures, and audiometric thresholds are described. At explantation there was evidence of fibrosis.

Interventions: To use histology and immunohistochemistry to determine the cellular response of the tissue associated with the electrode array at time of explantation.

Main outcome measures: Identification of the cell types, regional variations, and inflammatory marker expression in the fibrotic tissue associated with the array.

Results: Neutrophils and eosinophils were identified, along with a variable pattern of collagen deposition. CD68 and CD163-positive macrophages and T cells were variably distributed through the tissue and interleukin-1 beta and vascular endothelial growth factor receptor-2 expression was identified.

Conclusions: The expression profile is evidence of active inflammation in the tissue despite the time since implantation. This study is the first to characterize the tissue response to the array in a person undergoing reimplantation, and who can be followed to determine the individual response to arrays. It establishes that the investigation of explanted devices after soft-failure is feasible.
1531-7129
e445-e450
Hough, Kate
4ab6ce34-81be-4bff-bdc1-bdd22bbb0ace
Sanderson, Alan Peter
79d72ecf-7722-4a39-be5f-a041ba423c2b
Grasmeder, Mary
206e6b44-d1cd-43f5-99ac-588ab02d44ef
Mitchell, Tim
125f5e0f-500f-4ac2-8c54-9273c8f11cde
Verschuur, Carl
5e15ee1c-3a44-4dbe-ad43-ec3b50111e41
Newman, Tracey
322290cb-2e9c-445d-a047-00b1bea39a25
Hough, Kate
4ab6ce34-81be-4bff-bdc1-bdd22bbb0ace
Sanderson, Alan Peter
79d72ecf-7722-4a39-be5f-a041ba423c2b
Grasmeder, Mary
206e6b44-d1cd-43f5-99ac-588ab02d44ef
Mitchell, Tim
125f5e0f-500f-4ac2-8c54-9273c8f11cde
Verschuur, Carl
5e15ee1c-3a44-4dbe-ad43-ec3b50111e41
Newman, Tracey
322290cb-2e9c-445d-a047-00b1bea39a25

Hough, Kate, Sanderson, Alan Peter, Grasmeder, Mary, Mitchell, Tim, Verschuur, Carl and Newman, Tracey (2021) Inflammation at the tissue-electrode interface in a case of rapid deterioration in hearing performance leading to explant after cochlear implantation. Otology & Neurotology, 42 (4), e445-e450. (doi:10.1097/MAO.0000000000003014).

Record type: Article

Abstract

Objective: The reasons for soft failure after cochlear implantation require investigation. This study proposes a method to study and characterize the tissue response to the array in a case of soft failure in a person undergoing reimplantation.

Case: The woman in her 50s, with an underlying autoimmune condition, received a cochlear implant using hearing preservation technique after developing profound hearing loss more than 2 kHz with a moderate loss of less than 500 Hz over a 10-year period. The case was identified as a soft failure due to deteriorating performance, discomfort, and migration over the 10 months after implantation. Impedance telemetry, speech perception measures, and audiometric thresholds are described. At explantation there was evidence of fibrosis.

Interventions: To use histology and immunohistochemistry to determine the cellular response of the tissue associated with the electrode array at time of explantation.

Main outcome measures: Identification of the cell types, regional variations, and inflammatory marker expression in the fibrotic tissue associated with the array.

Results: Neutrophils and eosinophils were identified, along with a variable pattern of collagen deposition. CD68 and CD163-positive macrophages and T cells were variably distributed through the tissue and interleukin-1 beta and vascular endothelial growth factor receptor-2 expression was identified.

Conclusions: The expression profile is evidence of active inflammation in the tissue despite the time since implantation. This study is the first to characterize the tissue response to the array in a person undergoing reimplantation, and who can be followed to determine the individual response to arrays. It establishes that the investigation of explanted devices after soft-failure is feasible.

Text
Hough et al. ON-20-510 - Accepted Manuscript
Restricted to Repository staff only until 1 April 2022.
Request a copy

More information

Accepted/In Press date: 29 September 2020
Published date: 1 April 2021

Identifiers

Local EPrints ID: 444528
URI: http://eprints.soton.ac.uk/id/eprint/444528
ISSN: 1531-7129
PURE UUID: aade252f-ec1f-48ef-aa73-198157d649fe
ORCID for Kate Hough: ORCID iD orcid.org/0000-0002-5160-2517
ORCID for Tracey Newman: ORCID iD orcid.org/0000-0002-3727-9258

Catalogue record

Date deposited: 22 Oct 2020 16:34
Last modified: 01 Oct 2021 01:54

Export record

Altmetrics

Contributors

Author: Kate Hough ORCID iD
Author: Alan Peter Sanderson
Author: Mary Grasmeder
Author: Tim Mitchell
Author: Carl Verschuur
Author: Tracey Newman ORCID iD

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×