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A novel omega-3 glyceride mixture enhances enrichment of eicosapentaenoic acid and docosahexaenoic acid after single dosing in healthy older adults: results from a double-blind crossover trial

A novel omega-3 glyceride mixture enhances enrichment of eicosapentaenoic acid and docosahexaenoic acid after single dosing in healthy older adults: results from a double-blind crossover trial
A novel omega-3 glyceride mixture enhances enrichment of eicosapentaenoic acid and docosahexaenoic acid after single dosing in healthy older adults: results from a double-blind crossover trial
A glyceride mix of mono, di, and triglycerides increases solubilisation and enhances emulsification of omega-3 (ω-3) fatty acid (FA) containing lipids in the stomach. This allows for better access of digestive enzymes, pivotal for the release of bioactive ω-3 FA.

The objective was to compare the effect of a glyceride formulation and an ethyl ester (EE) formulation of EPA+DHA on concentrations of EPA and DHA in plasma following single dosing.

We conducted a double-blind crossover trial in which twenty healthy adults aged 50-70 y consumed a single dose (2.8 g EPA+DHA) of each EPA+DHA formulation without a meal in random order separated by a two-week wash out period. EPA and DHA were measured in plasma total lipid over the following 12 h.

EPA and DHA in plasma total lipid increased over 12 h with both formulations. A 10 x greater Δ concentration of EPA, 3 x greater Δ concentration of DHA, and 5 x greater Δ concentration of EPA+DHA was seen with the glyceride-EPA+DHA. The time at which the maximal concentrations of ω-3 FA occurred was 4 h earlier for EPA, 1 h earlier for DHA, and 2 h earlier for EPA+DHA when consuming glyceride-EPA+DHA.

A mix of mono, di, and triglycerides results in greater and faster incorporation of EPA and DHA into blood plasma lipid in the absence of a fatty meal. This may provide benefit to individuals on a low fat diet or with digestive impairments and could result in greater efficacy in clinical trials using ω-3 FA.
diglyceride, docosahexaenoic acid, eicosapentaenoic acid, emulsification, fish oil, monoglyceride, omega-3, triglyceride
0007-1145
Fisk, Helena
2483d346-75dd-41b3-a481-10f8bb39cd9f
Kindberg, Grete Mørk
e8cda3f7-225b-425d-8d60-e81cf9115f99
Hustvedt, Svein Olaf
58722204-1c73-4a94-9552-c4a6ebe9f714
Calder, Philip
1797e54f-378e-4dcb-80a4-3e30018f07a6
Fisk, Helena
2483d346-75dd-41b3-a481-10f8bb39cd9f
Kindberg, Grete Mørk
e8cda3f7-225b-425d-8d60-e81cf9115f99
Hustvedt, Svein Olaf
58722204-1c73-4a94-9552-c4a6ebe9f714
Calder, Philip
1797e54f-378e-4dcb-80a4-3e30018f07a6

Fisk, Helena, Kindberg, Grete Mørk, Hustvedt, Svein Olaf and Calder, Philip (2020) A novel omega-3 glyceride mixture enhances enrichment of eicosapentaenoic acid and docosahexaenoic acid after single dosing in healthy older adults: results from a double-blind crossover trial. British Journal of Nutrition. (doi:10.1017/S0007114520004031).

Record type: Article

Abstract

A glyceride mix of mono, di, and triglycerides increases solubilisation and enhances emulsification of omega-3 (ω-3) fatty acid (FA) containing lipids in the stomach. This allows for better access of digestive enzymes, pivotal for the release of bioactive ω-3 FA.

The objective was to compare the effect of a glyceride formulation and an ethyl ester (EE) formulation of EPA+DHA on concentrations of EPA and DHA in plasma following single dosing.

We conducted a double-blind crossover trial in which twenty healthy adults aged 50-70 y consumed a single dose (2.8 g EPA+DHA) of each EPA+DHA formulation without a meal in random order separated by a two-week wash out period. EPA and DHA were measured in plasma total lipid over the following 12 h.

EPA and DHA in plasma total lipid increased over 12 h with both formulations. A 10 x greater Δ concentration of EPA, 3 x greater Δ concentration of DHA, and 5 x greater Δ concentration of EPA+DHA was seen with the glyceride-EPA+DHA. The time at which the maximal concentrations of ω-3 FA occurred was 4 h earlier for EPA, 1 h earlier for DHA, and 2 h earlier for EPA+DHA when consuming glyceride-EPA+DHA.

A mix of mono, di, and triglycerides results in greater and faster incorporation of EPA and DHA into blood plasma lipid in the absence of a fatty meal. This may provide benefit to individuals on a low fat diet or with digestive impairments and could result in greater efficacy in clinical trials using ω-3 FA.

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Fisk et al_Final_BJN_revised_submision_V2 - Accepted Manuscript
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CONSORT flow chart_revised - Accepted Manuscript
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Figure 2 ugml inc DPA - Accepted Manuscript
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Figure 3 % inc DPA - Accepted Manuscript
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More information

Accepted/In Press date: 7 October 2020
e-pub ahead of print date: 13 October 2020
Keywords: diglyceride, docosahexaenoic acid, eicosapentaenoic acid, emulsification, fish oil, monoglyceride, omega-3, triglyceride

Identifiers

Local EPrints ID: 444565
URI: http://eprints.soton.ac.uk/id/eprint/444565
ISSN: 0007-1145
PURE UUID: 7aaeee43-40fe-4a78-9d82-9e5f3afa40a9
ORCID for Helena Fisk: ORCID iD orcid.org/0000-0002-9534-3246
ORCID for Philip Calder: ORCID iD orcid.org/0000-0002-6038-710X

Catalogue record

Date deposited: 26 Oct 2020 17:31
Last modified: 26 Nov 2021 02:59

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Contributors

Author: Helena Fisk ORCID iD
Author: Grete Mørk Kindberg
Author: Svein Olaf Hustvedt
Author: Philip Calder ORCID iD

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