Heterogeneity and 'memory' in stem cell populations
Heterogeneity and 'memory' in stem cell populations
Modern single cell experiments have revealed unexpected heterogeneity in apparently functionally 'pure' cell populations. However, we are still lacking a conceptual framework to understand this heterogeneity. Here, we propose that cellular memories – changes in the molecular status of a cell in response to a stimulus, that modify the ability of the cell to respond to future stimuli – are an essential ingredient in any such theory. We illustrate this idea by considering a simple age-structured model of stem cell proliferation that takes account of mitotic memories. Using this model we argue that asynchronous mitosis generates heterogeneity that is central to stem cell population function. This model naturally explains why stem cell numbers increase through life, yet regenerative potency simultaneously declines.
Stumpf, Patrick Simon
3aa7f861-0629-4a6c-a7be-3afd99e11314
Arai, Fumio
6f499041-0756-4b99-a40a-baaa9111221e
Macarthur, Benjamin
2c0476e7-5d3e-4064-81bb-104e8e88bb6b
1 November 2020
Stumpf, Patrick Simon
3aa7f861-0629-4a6c-a7be-3afd99e11314
Arai, Fumio
6f499041-0756-4b99-a40a-baaa9111221e
Macarthur, Benjamin
2c0476e7-5d3e-4064-81bb-104e8e88bb6b
Stumpf, Patrick Simon, Arai, Fumio and Macarthur, Benjamin
(2020)
Heterogeneity and 'memory' in stem cell populations.
Physical Biology, 17 (6), [065013].
(doi:10.1088/1478-3975/abba85).
Abstract
Modern single cell experiments have revealed unexpected heterogeneity in apparently functionally 'pure' cell populations. However, we are still lacking a conceptual framework to understand this heterogeneity. Here, we propose that cellular memories – changes in the molecular status of a cell in response to a stimulus, that modify the ability of the cell to respond to future stimuli – are an essential ingredient in any such theory. We illustrate this idea by considering a simple age-structured model of stem cell proliferation that takes account of mitotic memories. Using this model we argue that asynchronous mitosis generates heterogeneity that is central to stem cell population function. This model naturally explains why stem cell numbers increase through life, yet regenerative potency simultaneously declines.
Text
Stumpf 2020 Phys. Biol. 17 065013
- Version of Record
More information
Accepted/In Press date: 22 September 2020
e-pub ahead of print date: 28 October 2020
Published date: 1 November 2020
Additional Information:
Publisher Copyright:
© 2020 The Author(s). Published by IOP Publishing Ltd.
Identifiers
Local EPrints ID: 444571
URI: http://eprints.soton.ac.uk/id/eprint/444571
ISSN: 1478-3967
PURE UUID: 8799a842-8ba5-43cd-be0e-1634979120da
Catalogue record
Date deposited: 26 Oct 2020 17:31
Last modified: 17 Mar 2024 02:51
Export record
Altmetrics
Contributors
Author:
Patrick Simon Stumpf
Author:
Fumio Arai
Download statistics
Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.
View more statistics
