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UK consensus on pre-clinical vascular cognitive impairment functional outcomes assessment: Questionnaire and workshop proceedings

UK consensus on pre-clinical vascular cognitive impairment functional outcomes assessment: Questionnaire and workshop proceedings
UK consensus on pre-clinical vascular cognitive impairment functional outcomes assessment: Questionnaire and workshop proceedings

Assessment of outcome in preclinical studies of vascular cognitive impairment (VCI) is heterogenous. Through an ARUK Scottish Network supported questionnaire and workshop (mostly UK-based researchers), we aimed to determine underlying variability and what could be implemented to overcome identified challenges. Twelve UK VCI research centres were identified and invited to complete a questionnaire and attend a one-day workshop. Questionnaire responses demonstrated agreement that outcome assessments in VCI preclinical research vary by group and even those common across groups, may be performed differently. From the workshop, six themes were discussed: issues with preclinical models, reasons for choosing functional assessments, issues in interpretation of functional assessments, describing and reporting functional outcome assessments, sharing resources and expertise, and standardization of outcomes. Eight consensus points emerged demonstrating broadly that the chosen assessment should reflect the deficit being measured, and therefore that one assessment does not suit all models; guidance/standardisation on recording VCI outcome reporting is needed and that uniformity would be aided by a platform to share expertise, material, protocols and procedures thus reducing heterogeneity and so increasing potential for collaboration, comparison and replication. As a result of the workshop, UK wide consensus statements were agreed and future priorities for preclinical research identified.

Dementia, methodology, outcomes, questionnaire, vascular cognitive impairment
0271-678X
1402-1414
McFall, Aisling
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Hietamies, Tuuli M
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Bernard, Ashton
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Aimable, Margaux
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Allan, Stuart M
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Bath, Philip M
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Brezzo, Gaia
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Carare, Roxana O
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Carswell, Hilary V
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Clarkson, Andrew N
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Currie, Gillian
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Farr, Tracy D
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Fowler, Jill H
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Good, Mark
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Hainsworth, Atticus H
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Hall, Catherine
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Horsburgh, Karen
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Kalaria, Rajesh
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Kehoe, Patrick
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Lawrence, Catherine
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Macleod, Malcolm
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McColl, Barry W
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McNeilly, Alison
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Miller, Alyson A
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Miners, Scott
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Mok, Vincent
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O'Sullivan, Michael
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Platt, Bettina
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Sena, Emily S
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Sharp, Matthew
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Szymkowiak, Stefan
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Touyz, Rhian M
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Trueman, Rebecca C
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White, Claire
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McCabe, Chris
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Work, Lorraine M
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Quinn, Terence J
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McFall, Aisling
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Hietamies, Tuuli M
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Bernard, Ashton
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Aimable, Margaux
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Allan, Stuart M
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Bath, Philip M
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Brezzo, Gaia
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Carare, Roxana O
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Farr, Tracy D
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Fowler, Jill H
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Good, Mark
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Hainsworth, Atticus H
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Hall, Catherine
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Horsburgh, Karen
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Kalaria, Rajesh
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Kehoe, Patrick
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Lawrence, Catherine
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McNeilly, Alison
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Miller, Alyson A
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Miners, Scott
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Mok, Vincent
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O'Sullivan, Michael
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Platt, Bettina
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Sena, Emily S
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Sharp, Matthew
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Strangward, Patrick
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Szymkowiak, Stefan
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Touyz, Rhian M
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Trueman, Rebecca C
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White, Claire
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McCabe, Chris
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Work, Lorraine M
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Quinn, Terence J
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McFall, Aisling, Hietamies, Tuuli M, Bernard, Ashton, Aimable, Margaux, Allan, Stuart M, Bath, Philip M, Brezzo, Gaia, Carare, Roxana O, Carswell, Hilary V, Clarkson, Andrew N, Currie, Gillian, Farr, Tracy D, Fowler, Jill H, Good, Mark, Hainsworth, Atticus H, Hall, Catherine, Horsburgh, Karen, Kalaria, Rajesh, Kehoe, Patrick, Lawrence, Catherine, Macleod, Malcolm, McColl, Barry W, McNeilly, Alison, Miller, Alyson A, Miners, Scott, Mok, Vincent, O'Sullivan, Michael, Platt, Bettina, Sena, Emily S, Sharp, Matthew, Strangward, Patrick, Szymkowiak, Stefan, Touyz, Rhian M, Trueman, Rebecca C, White, Claire, McCabe, Chris, Work, Lorraine M and Quinn, Terence J (2020) UK consensus on pre-clinical vascular cognitive impairment functional outcomes assessment: Questionnaire and workshop proceedings. Journal of Cerebral Blood Flow & Metabolism, 40 (7), 1402-1414. (doi:10.1177/0271678X20910552).

Record type: Article

Abstract

Assessment of outcome in preclinical studies of vascular cognitive impairment (VCI) is heterogenous. Through an ARUK Scottish Network supported questionnaire and workshop (mostly UK-based researchers), we aimed to determine underlying variability and what could be implemented to overcome identified challenges. Twelve UK VCI research centres were identified and invited to complete a questionnaire and attend a one-day workshop. Questionnaire responses demonstrated agreement that outcome assessments in VCI preclinical research vary by group and even those common across groups, may be performed differently. From the workshop, six themes were discussed: issues with preclinical models, reasons for choosing functional assessments, issues in interpretation of functional assessments, describing and reporting functional outcome assessments, sharing resources and expertise, and standardization of outcomes. Eight consensus points emerged demonstrating broadly that the chosen assessment should reflect the deficit being measured, and therefore that one assessment does not suit all models; guidance/standardisation on recording VCI outcome reporting is needed and that uniformity would be aided by a platform to share expertise, material, protocols and procedures thus reducing heterogeneity and so increasing potential for collaboration, comparison and replication. As a result of the workshop, UK wide consensus statements were agreed and future priorities for preclinical research identified.

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More information

Accepted/In Press date: 6 December 2019
e-pub ahead of print date: 9 March 2020
Published date: 1 July 2020
Keywords: Dementia, methodology, outcomes, questionnaire, vascular cognitive impairment

Identifiers

Local EPrints ID: 444613
URI: http://eprints.soton.ac.uk/id/eprint/444613
ISSN: 0271-678X
PURE UUID: 55c0c700-d657-4391-a16a-19c1378ff9f7
ORCID for Roxana O Carare: ORCID iD orcid.org/0000-0001-6458-3776
ORCID for Matthew Sharp: ORCID iD orcid.org/0000-0002-6623-5078

Catalogue record

Date deposited: 27 Oct 2020 19:55
Last modified: 11 May 2024 01:43

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Contributors

Author: Aisling McFall
Author: Tuuli M Hietamies
Author: Ashton Bernard
Author: Margaux Aimable
Author: Stuart M Allan
Author: Philip M Bath
Author: Gaia Brezzo
Author: Roxana O Carare ORCID iD
Author: Hilary V Carswell
Author: Andrew N Clarkson
Author: Gillian Currie
Author: Tracy D Farr
Author: Jill H Fowler
Author: Mark Good
Author: Atticus H Hainsworth
Author: Catherine Hall
Author: Karen Horsburgh
Author: Rajesh Kalaria
Author: Patrick Kehoe
Author: Catherine Lawrence
Author: Malcolm Macleod
Author: Barry W McColl
Author: Alison McNeilly
Author: Alyson A Miller
Author: Scott Miners
Author: Vincent Mok
Author: Michael O'Sullivan
Author: Bettina Platt
Author: Emily S Sena
Author: Matthew Sharp ORCID iD
Author: Patrick Strangward
Author: Stefan Szymkowiak
Author: Rhian M Touyz
Author: Rebecca C Trueman
Author: Claire White
Author: Chris McCabe
Author: Lorraine M Work
Author: Terence J Quinn

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