Can alcohol dependent patients adhere to an 'As-needed' medication regimen?

Sinclair, Julia, Chick, Jonathan, Sørensen, Per, Kiefer, Falk, Batel, Philippe and Gual, Antoni (2014) Can alcohol dependent patients adhere to an 'As-needed' medication regimen? European Addiction Research, 20 (5), 209-217. (doi:10.1159/000357865).

Abstract

A pooled analysis of 'as-needed medication use' data from 1,276 patients in two randomised, double-blind, placebo-controlled, parallel-group trials of nalmefene in the treatment of alcohol dependence was performed to explore whether an 'as-needed' regimen is an acceptable and feasible strategy in patients seeking help for alcohol dependence. Adherence was defined as alcohol consumption and medication intake, or no alcohol consumption (with or without medication intake). Nalmefene was taken on approximately half of the study days; placebo was taken more often than nalmefene (52.8 vs. 64.5% of days, respectively). In each treatment group medication intake appeared to vary according to patients' needs in that intake correlated with the baseline drinking pattern. Sixty-eight percent of the nalmefene-treated patients (78% of the study completers) adhered to the as-needed treatment regimen on at least 80% of the study days. In conclusion, as-needed use is a feasible, patient-centred approach that engages patients with alcohol dependence in the active management of their illness.

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Contributors

Author: Julia Sinclair

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