The University of Southampton
University of Southampton Institutional Repository
Warning ePrints Soton is experiencing an issue with some file downloads not being available. We are working hard to fix this. Please bear with us.

Sex-specific associations between cardiac workload, peripheral vascular calcification and bone mineral density: The Gambian Bone and Muscle Ageing Study

Sex-specific associations between cardiac workload, peripheral vascular calcification and bone mineral density: The Gambian Bone and Muscle Ageing Study
Sex-specific associations between cardiac workload, peripheral vascular calcification and bone mineral density: The Gambian Bone and Muscle Ageing Study
Non‐communicable diseases (NCD) are rapidly rising in Africa, with multi‐morbidity increasing the burden on health and social care. Osteoporosis and cardiovascular disease (CVD) both share common risk factors; both often remain undiagnosed until a major life‐threatening event occurs. We investigated the associations between cardiac workload, peripheral vascular calcification (PVC) and bone parameters in Gambian adults. The Gambian Bone and Muscle Ageing Study (GamBAS) recruited 249 women and 239 men aged 40‐75+ years. Body composition and areal bone mineral density (aBMD) were measured using dual energy x‐ray absorptiometry; peripheral‐ quantitative computed tomography (pQCT) scans were performed at the radius and tibia. Supine blood pressure and heart rate were measured and used to calculate rate pressure product and pulse pressure. Presence of PVC was determined from tibia pQCT scans. Sex‐interactions were tested (denoted as p‐int); adjustments were made for residuals of appendicular lean mass (ALM) and fat mass (FM). There were negative associations between rate pressure product and aBMD in women only, all p‐int<0.05; after adjustment for ALM residuals, for every 10% increase in rate pressure product, aBMD was lower at the: whole‐body (‐0.6%[‐1.2,‐0.1]) , femoral neck (‐0.9%[‐1.8,‐0.05]), L1‐L4 (‐0.6%[‐1.7,0.5]) and radius (‐1.9%[‐2.8,‐0.9]); there were similar associations when adjusted for FM residuals. Similar negative associations were seen between pulse pressure and aBMD in women only. PVC were found in 26.6% men, 22.5% women; women but not men with calcification had poorer cardiac health, and negative associations with aBMD (all sites p‐int<0.001). There were consistent associations with cardiac parameters and pQCT outcomes at the radius and tibia in women only. Multiple markers of cardiac health are associated with poorer bone health in Gambian women. In the context of epidemiological transition and changing NCD burden, there is a need to identify preventative strategies to slow/prevent the rising burden in CVD and osteoporosis in Sub‐Saharan Africa.
AGING, ANALYSIS/QUANTITATION OF BONE; DXA, EPIDEMIOLOGY GENERAL POPULATION STUDIES, SKELETAL MUSCLE
0884-0431
Zengin, Ayse
b2023a08-983d-45bc-ba35-02b5e08aaaa3
Jarjou, Landing M.
ca2935b3-3c0d-4541-bff7-afd191cf502b
Janha, Ramatoulie E.
1a14cb0a-33f3-47f7-8da4-3f7e431d555e
Prentice, Ann
675810ad-8022-453c-b3a3-8afff0e1a920
Cooper, Cyrus
e05f5612-b493-4273-9b71-9e0ce32bdad6
Ebeling, Peter R.
71a1d109-c0fe-438d-9d01-660012eb7049
Ward, Kate
39bd4db1-c948-4e32-930e-7bec8deb54c7
Zengin, Ayse
b2023a08-983d-45bc-ba35-02b5e08aaaa3
Jarjou, Landing M.
ca2935b3-3c0d-4541-bff7-afd191cf502b
Janha, Ramatoulie E.
1a14cb0a-33f3-47f7-8da4-3f7e431d555e
Prentice, Ann
675810ad-8022-453c-b3a3-8afff0e1a920
Cooper, Cyrus
e05f5612-b493-4273-9b71-9e0ce32bdad6
Ebeling, Peter R.
71a1d109-c0fe-438d-9d01-660012eb7049
Ward, Kate
39bd4db1-c948-4e32-930e-7bec8deb54c7

Zengin, Ayse, Jarjou, Landing M., Janha, Ramatoulie E., Prentice, Ann, Cooper, Cyrus, Ebeling, Peter R. and Ward, Kate (2020) Sex-specific associations between cardiac workload, peripheral vascular calcification and bone mineral density: The Gambian Bone and Muscle Ageing Study. Journal of Bone and Mineral Research. (doi:10.1002/jbmr.4196).

Record type: Article

Abstract

Non‐communicable diseases (NCD) are rapidly rising in Africa, with multi‐morbidity increasing the burden on health and social care. Osteoporosis and cardiovascular disease (CVD) both share common risk factors; both often remain undiagnosed until a major life‐threatening event occurs. We investigated the associations between cardiac workload, peripheral vascular calcification (PVC) and bone parameters in Gambian adults. The Gambian Bone and Muscle Ageing Study (GamBAS) recruited 249 women and 239 men aged 40‐75+ years. Body composition and areal bone mineral density (aBMD) were measured using dual energy x‐ray absorptiometry; peripheral‐ quantitative computed tomography (pQCT) scans were performed at the radius and tibia. Supine blood pressure and heart rate were measured and used to calculate rate pressure product and pulse pressure. Presence of PVC was determined from tibia pQCT scans. Sex‐interactions were tested (denoted as p‐int); adjustments were made for residuals of appendicular lean mass (ALM) and fat mass (FM). There were negative associations between rate pressure product and aBMD in women only, all p‐int<0.05; after adjustment for ALM residuals, for every 10% increase in rate pressure product, aBMD was lower at the: whole‐body (‐0.6%[‐1.2,‐0.1]) , femoral neck (‐0.9%[‐1.8,‐0.05]), L1‐L4 (‐0.6%[‐1.7,0.5]) and radius (‐1.9%[‐2.8,‐0.9]); there were similar associations when adjusted for FM residuals. Similar negative associations were seen between pulse pressure and aBMD in women only. PVC were found in 26.6% men, 22.5% women; women but not men with calcification had poorer cardiac health, and negative associations with aBMD (all sites p‐int<0.001). There were consistent associations with cardiac parameters and pQCT outcomes at the radius and tibia in women only. Multiple markers of cardiac health are associated with poorer bone health in Gambian women. In the context of epidemiological transition and changing NCD burden, there is a need to identify preventative strategies to slow/prevent the rising burden in CVD and osteoporosis in Sub‐Saharan Africa.

Text
GamBAS cardio_JBMR_accepted_FINAL_PROOFS_combined_Kate - Accepted Manuscript
Download (11MB)

More information

Accepted/In Press date: 7 October 2020
e-pub ahead of print date: 29 October 2020
Keywords: AGING, ANALYSIS/QUANTITATION OF BONE; DXA, EPIDEMIOLOGY GENERAL POPULATION STUDIES, SKELETAL MUSCLE

Identifiers

Local EPrints ID: 444845
URI: http://eprints.soton.ac.uk/id/eprint/444845
ISSN: 0884-0431
PURE UUID: 933b5e50-42f5-46d4-ba33-c29058f06d35
ORCID for Cyrus Cooper: ORCID iD orcid.org/0000-0003-3510-0709
ORCID for Kate Ward: ORCID iD orcid.org/0000-0001-7034-6750

Catalogue record

Date deposited: 06 Nov 2020 17:31
Last modified: 26 Nov 2021 06:17

Export record

Altmetrics

Contributors

Author: Ayse Zengin
Author: Landing M. Jarjou
Author: Ramatoulie E. Janha
Author: Ann Prentice
Author: Cyrus Cooper ORCID iD
Author: Peter R. Ebeling
Author: Kate Ward ORCID iD

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×