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Retinal imaging in Alzheimer's and neurodegenerative diseases

Retinal imaging in Alzheimer's and neurodegenerative diseases
Retinal imaging in Alzheimer's and neurodegenerative diseases

In the last 20 years, research focused on developing retinal imaging as a source of potential biomarkers for Alzheimer's disease and other neurodegenerative diseases, has increased significantly. The Alzheimer's Association and the Alzheimer's & Dementia: Diagnosis, Assessment, Disease Monitoring editorial team (companion journal to Alzheimer's & Dementia) convened an interdisciplinary discussion in 2019 to identify a path to expedite the development of retinal biomarkers capable of identifying biological changes associated with AD, and for tracking progression of disease severity over time. As different retinal imaging modalities provide different types of structural and/or functional information, the discussion reflected on these modalities and their respective strengths and weaknesses. Discussion further focused on the importance of defining the context of use to help guide the development of retinal biomarkers. Moving from research to context of use, and ultimately to clinical evaluation, this article outlines ongoing retinal imaging research today in Alzheimer's and other brain diseases, including a discussion of future directions for this area of study.

Alzheimer's disease, biomarkers, early detection, eye, neurodegeneration, retina, retinal imaging
1552-5260
Snyder, Peter J.
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Alber, Jessica
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Alt, Clemens
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Bain, Lisa J.
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Bouma, Brett E.
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Bouwman, Femke H.
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Cabrera DeBuc, Delia
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Campbell, Melanie C.W.
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Carrillo, Maria C.
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Chew, Emily Y.
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Cordeiro, M. Francesca
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Dueñas, Michael R.
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Fernández, Brian M.
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Koronyo‐Hamaoui, Maya
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La Morgia, Chiara
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Carare, Roxana-Octavia
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Sadda, Srinivas R.
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van Wijngaarden, Peter
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Snyder, Heather M.
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Snyder, Peter J.
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Alber, Jessica
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Alt, Clemens
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Bain, Lisa J.
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Bouma, Brett E.
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Bouwman, Femke H.
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Cabrera DeBuc, Delia
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Campbell, Melanie C.W.
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Carrillo, Maria C.
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Chew, Emily Y.
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Cordeiro, M. Francesca
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Dueñas, Michael R.
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Fernández, Brian M.
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Koronyo‐Hamaoui, Maya
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La Morgia, Chiara
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Carare, Roxana-Octavia
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Sadda, Srinivas R.
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van Wijngaarden, Peter
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Snyder, Heather M.
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Snyder, Peter J., Alber, Jessica, Alt, Clemens, Bain, Lisa J., Bouma, Brett E., Bouwman, Femke H., Cabrera DeBuc, Delia, Campbell, Melanie C.W., Carrillo, Maria C., Chew, Emily Y., Cordeiro, M. Francesca, Dueñas, Michael R., Fernández, Brian M., Koronyo‐Hamaoui, Maya, La Morgia, Chiara, Carare, Roxana-Octavia, Sadda, Srinivas R., van Wijngaarden, Peter and Snyder, Heather M. (2020) Retinal imaging in Alzheimer's and neurodegenerative diseases. Alzheimer's & Dementia. (doi:10.1002/alz.12179).

Record type: Review

Abstract

In the last 20 years, research focused on developing retinal imaging as a source of potential biomarkers for Alzheimer's disease and other neurodegenerative diseases, has increased significantly. The Alzheimer's Association and the Alzheimer's & Dementia: Diagnosis, Assessment, Disease Monitoring editorial team (companion journal to Alzheimer's & Dementia) convened an interdisciplinary discussion in 2019 to identify a path to expedite the development of retinal biomarkers capable of identifying biological changes associated with AD, and for tracking progression of disease severity over time. As different retinal imaging modalities provide different types of structural and/or functional information, the discussion reflected on these modalities and their respective strengths and weaknesses. Discussion further focused on the importance of defining the context of use to help guide the development of retinal biomarkers. Moving from research to context of use, and ultimately to clinical evaluation, this article outlines ongoing retinal imaging research today in Alzheimer's and other brain diseases, including a discussion of future directions for this area of study.

Text
Retinal imaging in Alzheimer’s - Version of Record
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More information

Accepted/In Press date: 27 July 2020
Published date: 8 October 2020
Keywords: Alzheimer's disease, biomarkers, early detection, eye, neurodegeneration, retina, retinal imaging

Identifiers

Local EPrints ID: 444933
URI: http://eprints.soton.ac.uk/id/eprint/444933
ISSN: 1552-5260
PURE UUID: a35bfd91-30ee-4acd-82dd-ff8f70cd3fc6
ORCID for Roxana-Octavia Carare: ORCID iD orcid.org/0000-0001-6458-3776

Catalogue record

Date deposited: 12 Nov 2020 17:31
Last modified: 23 Sep 2021 02:37

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Contributors

Author: Peter J. Snyder
Author: Jessica Alber
Author: Clemens Alt
Author: Lisa J. Bain
Author: Brett E. Bouma
Author: Femke H. Bouwman
Author: Delia Cabrera DeBuc
Author: Melanie C.W. Campbell
Author: Maria C. Carrillo
Author: Emily Y. Chew
Author: M. Francesca Cordeiro
Author: Michael R. Dueñas
Author: Brian M. Fernández
Author: Maya Koronyo‐Hamaoui
Author: Chiara La Morgia
Author: Srinivas R. Sadda
Author: Peter van Wijngaarden
Author: Heather M. Snyder

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