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The endometrial factor in recurrent pregnancy loss

The endometrial factor in recurrent pregnancy loss
The endometrial factor in recurrent pregnancy loss
The endometrium is a highly adaptable and dynamic tissue that has the ability to differentiate into secretory decidual cells capable of establishing and sustaining pregnancy. For decades, the decidualised endometrium has been thought to play a passive role in implantation. This paradigm has now been challenged with findings that the decidua in fact acts as a biosensor of embryo-quality, selecting those that are most likely to progress to term and make maternal investment in pregnancy worthwhile. In this chapter, the mechanisms through which the endometrium differentiates into the highly selective decidua, and the molecular basis for the embryo-endometrial cross-talk will be reviewed. Disruptions in this mechanism that have been linked to recurrent pregnancy loss will also be discussed. In addition, the authors provide an overview on local immunological factors that might be accountable for recurrent miscarriage, and a discussion of clinical implications of such data.
CRC Press
Cheong, Ying
4efbba2a-3036-4dce-82f1-8b4017952c83
Borges Manna, Luiza
8f7cedf5-8fdc-454b-962b-b36f54193bd4
Carp, Howard
Cheong, Ying
4efbba2a-3036-4dce-82f1-8b4017952c83
Borges Manna, Luiza
8f7cedf5-8fdc-454b-962b-b36f54193bd4
Carp, Howard

Cheong, Ying and Borges Manna, Luiza (2020) The endometrial factor in recurrent pregnancy loss. In, Carp, Howard (ed.) Recurrent Pregnancy Loss: Causes, Controversies and Treatment. Third Edition ed. CRC Press.

Record type: Book Section

Abstract

The endometrium is a highly adaptable and dynamic tissue that has the ability to differentiate into secretory decidual cells capable of establishing and sustaining pregnancy. For decades, the decidualised endometrium has been thought to play a passive role in implantation. This paradigm has now been challenged with findings that the decidua in fact acts as a biosensor of embryo-quality, selecting those that are most likely to progress to term and make maternal investment in pregnancy worthwhile. In this chapter, the mechanisms through which the endometrium differentiates into the highly selective decidua, and the molecular basis for the embryo-endometrial cross-talk will be reviewed. Disruptions in this mechanism that have been linked to recurrent pregnancy loss will also be discussed. In addition, the authors provide an overview on local immunological factors that might be accountable for recurrent miscarriage, and a discussion of clinical implications of such data.

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More information

Published date: 2020

Identifiers

Local EPrints ID: 444976
URI: http://eprints.soton.ac.uk/id/eprint/444976
PURE UUID: e02ad2ce-fedc-4423-b6bd-ef9c7cbe1bc7
ORCID for Ying Cheong: ORCID iD orcid.org/0000-0001-7687-4597

Catalogue record

Date deposited: 13 Nov 2020 17:33
Last modified: 18 Feb 2021 17:11

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Contributors

Author: Ying Cheong ORCID iD
Author: Luiza Borges Manna
Editor: Howard Carp

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