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Combinatorial library synthesis of antioxidant compounds

Combinatorial library synthesis of antioxidant compounds
Combinatorial library synthesis of antioxidant compounds
Since oxidative cellular damage contributes to the development of cancers, heart disease and ageing, the synthesis of antioxidative agents which are able to either prevent or mitigate oxidative stress to cells is an important area of investigation. Combinatorial chemistry has had a profound impact on the discovery and optimisation of potential lead compounds, especially in the medicinal field. This review details recent examples of combinatorial chemistry dealing with the synthesis of novel antioxidants with an emphasis on solid phase compound synthesis and parallel library synthesis.
1386-2073
421-423
Mittoo, S.
595c0eca-0eea-4e8c-aaf8-936a1a438d48
Mittoo, S.
595c0eca-0eea-4e8c-aaf8-936a1a438d48

Mittoo, S. (2006) Combinatorial library synthesis of antioxidant compounds. Combinatorial Chemistry & High Throughput Screening, 9 (6), 421-423. (doi:10.2174/138620706777698490).

Record type: Article

Abstract

Since oxidative cellular damage contributes to the development of cancers, heart disease and ageing, the synthesis of antioxidative agents which are able to either prevent or mitigate oxidative stress to cells is an important area of investigation. Combinatorial chemistry has had a profound impact on the discovery and optimisation of potential lead compounds, especially in the medicinal field. This review details recent examples of combinatorial chemistry dealing with the synthesis of novel antioxidants with an emphasis on solid phase compound synthesis and parallel library synthesis.

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Published date: 2006

Identifiers

Local EPrints ID: 44501
URI: http://eprints.soton.ac.uk/id/eprint/44501
ISSN: 1386-2073
PURE UUID: 3fb24151-8842-444a-82d6-59c9739c7168

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Date deposited: 08 Mar 2007
Last modified: 13 Mar 2019 21:07

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